Catalog No.
YHE52801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys33-Pro512
Predicted molecular weight
54.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P47895
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Aldehyde dehydrogenase family 1 member A3, Aldehyde dehydrogenase 6, ALDH1A3, RalDH3, ALDH6, Retinaldehyde dehydrogenase 3, RALDH-3
SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation., PMID:40512369
Glucosylceramide Synthase, a Key Enzyme in Sphingolipid Metabolism, Regulates Expression of Genes Accounting for Cancer Drug Resistance., PMID:40507922
Omaveloxolone, But Not Dimethyl Fumarate, Improves Cardiac Function in Friedreich's Ataxia Mice With Severe Cardiomyopathy., PMID:40501183
The interaction of HT-2 toxin and Akt1 on gene expression regulation in Kashin-Beck disease pathogenesis., PMID:40449756
Opposing effects between retinoic acid and Fibroblast growth factor in patterning the common crus and semicircular canals of the inner ear., PMID:40436241
Oral 7,8-Dihydroxyflavone Protects Retinal Ganglion Cells by Modulating the Gut-Retina Axis and Inhibiting Ferroptosis via the Indoleacrylic Acid-AhR-ALDH1A3-FSP1 Pathway., PMID:40365730
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition., PMID:40304759
Asymmetric cell division of ALDH1-positive cancer stem cells generates glycolytic metabolically diverse cell populations., PMID:40263471
PPAR γ changing ALDH1A3 content to regulate lipid metabolism and inhibit lung cancer cell growth., PMID:40198404
The potential of ARL4C and its-mediated genes in atherosclerosis and agent development., PMID:40176913
Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism., PMID:40122809
MMP2 regulates proliferation and differentiation in chicken primary myoblasts, and RNA-seq screens for key genes., PMID:39863094
Structural characteization and anti-colorectal cancer activity of a fucogalactan purified from Ganoderma tsugae., PMID:39843104
Pancreatic expression of CPT1A is essential for whole body glucose homeostasis by supporting glucose-stimulated insulin secretion., PMID:39814231
ALDH Enzymes and Hematological Diseases: A Scoping Review of Literature., PMID:39726306
ALDH1A3 Contributes to Radiation-Induced Inhibition of Self-Renewal and Promotes Proliferative Activity of p53-Deficient Glioblastoma Stem Cells at the Onset of Differentiation., PMID:39513909
Computational investigations of flavonoids as ALDH isoform inhibitors for treatment of cancer., PMID:39503629
Identification and Verification of Potential Markers Related to Myocardial Fibrosis by Bioinformatics Analysis., PMID:39387979
Disulfiram-Copper Potentiates Anticancer Efficacy of Standard Chemo-therapy Drugs in Bladder Cancer Animal Model through ROS-Autophagy-Ferroptosis Signalling Cascade., PMID:39323342
ALDH1A3 is the switch that determines the balance of ALDH+ and CD24-CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer., PMID:39251846
ALDH and cancer stem cells: Pathways, challenges, and future directions in targeted therapy., PMID:39222837
β-Cell Dedifferentiation in HOMA-βlow and HOMA-βhigh Subjects., PMID:39133811
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma., PMID:39111285
Circular RNA LMBR1 inhibits bladder cancer progression by enhancing expression of the protein ALDH1A3., PMID:39036604
Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor., PMID:38999066
ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma., PMID:38963759
Pharmacologic Targeting of Histone H3K27 Acetylation/BRD4-dependent Induction of ALDH1A3 for Early-phase Drug Tolerance of Gastric Cancer., PMID:38669046
Burn Pit Smoke Condensate-Mediated Toxicity in Human Airway Epithelial Cells., PMID:38652897
Histone H3K36me3 mediates the genomic instability of Benzo[a]pyrene in human bronchial epithelial cells., PMID:38367693
Evaluating the efficacy and mechanisms of Hua-Zhuo-Ning-Fu-Decoction on psoriasis using integrated bioinformatics analysis and metabolomics., PMID:38316220
Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity., PMID:38237895
ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription., PMID:38169509
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition., PMID:38168770
Luminal B Breast Cancer Coexpressing p62 and ALDH1A3 Is Less Susceptible to Radiotherapy., PMID:38160009
β-escin activates ALDH and prevents cigarette smoke-induced cell death., PMID:38016364
Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells., PMID:37947601
ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms., PMID:37904003
Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells., PMID:37791907
ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway., PMID:37753740
Novel Function of Cancer Stem Cell Marker ALDH1A3 in Glioblastoma: Pro-Angiogenesis through Paracrine PAI-1 and IL-8., PMID:37686698
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma., PMID:37647805
Genome-Wide Association Study of Lactation Traits in Chinese Holstein Cows in Southern China., PMID:37570353
Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer., PMID:37563546
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling., PMID:37551838
The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity., PMID:37536498
15q26.3 deletions distal to IGF1R cause growth retardation, congenital heart defect and skeletal anomalies: Case report and review of literature., PMID:37434556
Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice., PMID:37364047
High expression of PKCλ and ALDH1A3 indicates a poor prognosis, and PKCλ is required for the asymmetric cell division of ALDH1A3-positive cancer stem cells in PDAC., PMID:37267864
METTL3-mediated ALDH m6A methylation regulates the malignant behavior of BMI1+ HNSCC stem cells., PMID:37249063
Exploring the Molecular Players behind the Potentiation of Chemotherapy Effects by Durvalumab in Lung Adenocarcinoma Cell Lines., PMID:37242727
For research use only. Not for human or drug use.
