Catalog No.
YHK46301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp304
Predicted molecular weight
36.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NUX5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protection of telomeres protein 1, hPot1, POT1-like telomere end-binding protein, POT1
Mutational heterogeneities in STAT3 and clonal hematopoiesis-related genes in acquired pure red cell aplasia., PMID:40202536
Active telomere elongation by a subclass of cancer-associated POT1 mutations., PMID:40015989
An Integrative Multitiered Computational Analysis for Better Understanding the Structure and Function of 85 Miniproteins., PMID:39974886
Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival., PMID:39922874
Elucidating the effects of manganese on the growth and cadmium accumulation of OsNRAMP5 mutant rice., PMID:39922161
A novel POT1-TPD presentation: A germline pathogenic POT1 variant discovered in a patient with newly diagnosed posterior fossa ependymoma., PMID:39864275
Genomic Profiling of Cardiac Angiosarcoma Reveals Novel Targetable KDR Variants, Recurrent MED12 Mutations, and a High Burden of Germline POT1 Alterations., PMID:39820259
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres., PMID:39763972
Response to EGFR/NTRK/MET Co-Inhibition Guided by Paired NGS in Advanced NSCLC With Acquired EGFR L858R/T790M/C797S Mutations., PMID:39729710
Altered TP53, CDKN2A, ATM, EPHA7, POT1, CHEK1, GRIN2A, and EGFR Predict Shorter Survival in Penile Squamous Cell Carcinoma., PMID:39694330
Molecular Mechanisms of Phosphate Use Efficiency in Arabidopsis via Penicillium olsonii TLL1., PMID:39684576
Identification of biallelic POLA2 variants in two families with an autosomal recessive telomere biology disorder., PMID:39616267
Combatting cellular immortality in cancers by targeting the shelterin protein complex., PMID:39578854
The expression of shelterin genes and telomere repeat analysis and their effect on Alzheimer's disease., PMID:39503976
Telomere maintenance and the DNA damage response: a paradoxical alliance., PMID:39483338
Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutations., PMID:39316766
Phase separation of hnRNPA1 and TERRA regulates telomeric stability., PMID:39313323
Identification and functional validation of a novel pathogenic POT1 germline variant p.G95V in familial melanoma., PMID:39247651
Molecular profiling METex14+ non-small cell lung cancer (NSCLC): Impact of histology., PMID:39241297
Heterozygous RPA2 variant as a novel genetic cause of telomere biology disorders., PMID:39231615
Dissecting the oncogenic mechanisms of POT1 cancer mutations through deep scanning mutagenesis., PMID:39229243
Protection of the Telomeric Junction by the Shelterin Complex., PMID:39229120
Protection of the Telomeric Junction by the Shelterin Complex., PMID:39207958
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita., PMID:39198715
Overexpression of protection of telomeres 1 (POT1), a single-stranded DNA-binding proteins in alfalfa (Medicago sativa), enhances seed vigor., PMID:39097069
CoPixie, a novel algorithm for single-particle track colocalization, enables efficient quantification of telomerase dynamics at telomeres., PMID:39082280
At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery., PMID:39059369
Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells., PMID:38982492
SNF1 plays a crucial role in the utilization of n-alkane and transcriptional regulation of the genes involved in it in the yeast Yarrowia lipolytica., PMID:38975102
The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging., PMID:38891017
Variant ranking pipeline for complex familial disorders., PMID:38866901
POT1 tumour predisposition: a broader spectrum of associated malignancies and proposal for additional screening program., PMID:38839987
POT1 recruits and regulates CST-Polα/primase at human telomeres., PMID:38838667
A persistent variant telomere sequence in a human pedigree., PMID:38824190
POT1 and multiple primary melanomas: the dermatological phenotype., PMID:38724174
Germline POT1 mutation and neuroblastoma: A mere coincidence or true association., PMID:38706191
Telomere-lengthening germline variants predispose to a syndromic papillary thyroid cancer subtype., PMID:38688277
A POT1 Founder Variant Associated with Early Onset Recurrent Melanoma and Various Solid Malignancies., PMID:38540414
Potassium attenuates drought damage by regulating sucrose metabolism and gene expression in sesame leaf., PMID:38522132
Among-population variation in telomere regulatory proteins and their potential role as hidden drivers of intraspecific variation in life history., PMID:38509838
Upregulation of shelterin and CST genes and longer telomeres are associated with unfavorable prognostic characteristics in prostate cancer., PMID:38503134
Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells., PMID:38496440
Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1., PMID:38429270
Cashew gum hydrogel as an alternative to minimize the effect of drought stress on soybean., PMID:38272955
Protein-Protein Interactions of Seryl-tRNA Synthetases with Emphasis on Human Counterparts and Their Connection to Health and Disease., PMID:38255739
Germline POT1 Variants: A Critical Perspective on POT1 Tumor Predisposition Syndrome., PMID:38254993
Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing., PMID:38175592
The Altered Functions of Shelterin Components in ALT Cells., PMID:38069153
A novel telomere biology disease-associated gastritis identified through a whole exome sequencing-driven approach., PMID:37994393
For research use only. Not for human or drug use.
