Catalog No.
YHD25101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His40-Lys310
Predicted molecular weight
33.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17612
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRKACA, PKACA, PKA C-alpha, cAMP-dependent protein kinase catalytic subunit alpha
MiRNA-24 Downregulates KLF6 Affecting STAT3 Protein Expression and Phosphorylation Regulating Melanogenesis in Cashmere Goat coat., PMID:40506042
Local and distal changes in dynamics are caused by an L205R Cushing's syndrome mutant in PRKACA., PMID:40504162
Untangling hidden players of PCOS: From transcriptomics to key biomarkers using WGCNA, LASSO and ROC analysis., PMID:40480394
Kinases Associated with Herpes Zoster Virus Infection Unveiled by Phosphoromics Profiling., PMID:40469476
Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology., PMID:40421220
Characterisation of a GNAS variant linked to cortisol-producing adrenocortical adenoma., PMID:40391091
Identification of differentially expressed genes in resting human skeletal muscle of sedentary versus strength and endurance- trained individuals using bioinformatics analysis and in vitro validation., PMID:40352223
Ethyl caffeate alleviates inflammatory response and promotes recovery in septic-acute lung injury via the TNF-α/NF-κB/MMP9 Axis., PMID:40220405
Meiotic arrest, resumption and TZP retraction in bovine COCs undergoing pre-IVM: lessons from a refined GV stage classification., PMID:40152672
A Rare Case of PRKACA Duplication-Associated Childhood-Onset Primary Pigmented Nodular Adrenocortical Disease., PMID:40066253
Neuroprotective effects of macrostemonoside T on glutamate-induced injury in HT22 cells., PMID:39993610
Identification and Validation of Biomarkers for Alzheimer's Disease Based on Akt and Wnt Signaling Pathways in Mouse Models., PMID:39992588
Nsun2 controls cardiac homeostasis and hypertrophic response by regulating PRKACA expression., PMID:39990213
The proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases., PMID:39954016
A novel high-throughput screening platform to identify inhibitors of DNAJB1-PRKACA-driven transcriptional activity in fibrolamellar carcinoma., PMID:39947627
Rescue of CUMS-induced HPA axis hyperfunction and hypothalamic synaptic deficits by Citrus aurantium L. cv. Daidai essential oil via the cAMP/PKA/Grin2b pathway., PMID:39894418
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction., PMID:39842746
LCAT deficiency promotes hepatocellular carcinoma progression and lenvatinib resistance by promoting triglyceride catabolism and fatty acid oxidation., PMID:39842501
How Do I Diagnose Fibrolamellar Carcinoma?, PMID:39814265
The Combination of Resveratrol and Conjugated Linoleic Acid Dienes Enhances the Individual Effects of These Molecules on De Novo Fatty Acid Biosynthesis in 3T3-L1 Adipocytes., PMID:39769194
Liver cancer multiomics reveals diverse protein kinase A disruptions convergently produce fibrolamellar hepatocellular carcinoma., PMID:39738196
Network Pharmacology and Molecular Docking Study on the Mechanism of the Therapeutic Effect of Strychni Semen in NSCLC., PMID:39736533
Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking., PMID:39733639
Models of fibrolamellar carcinomas, tools for evaluation of a new era of treatments., PMID:39582856
Receptor-Interacting Protein Kinase 3 Augments Neuroinflammation by Facilitating Neutrophil Infiltration during an Ischemic Stroke., PMID:39571563
ASIC1a regulates airway epithelial cell pyroptosis in acute lung injury by NLRP3-Caspase1-GSDMD pathway., PMID:39549550
Shengqiyichang decoction regulates antitumor immunity in colorectal cancer by downregulating lymphocyte antigen 6 family member G6D via the protein kinase B/p38 mitogen-activated protein kinase signaling pathway., PMID:39524806
Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma., PMID:39449143
Integrated metabolomics and network pharmacology reveal the procoagulant mechanisms of Cirsium setosum extracts., PMID:39395239
The molecular genetics of adrenal cushing., PMID:39388056
Anti-liver cancer therapeutic targets and safety of usenamine A in experimental liver cancer., PMID:39360781
DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming., PMID:39326063
Comparison of the gene expression profiles of endometrial and trophoblastic cells in women with recurrent miscarriage: A bioinformatics approach., PMID:39205919
Somatic Molecular Heterogeneity in Bilateral Macronodular Adrenocortical Disease (BMAD) Differs Among the Pathological Subgroups., PMID:39180662
Exploring the Effect of Active Components in Oil Tree Peony Seed Meal on Swine Disease Resistance and its Potential Mechanisms Based on Network Pharmacology and Molecular Docking., PMID:39172434
The molecular and network mechanisms of antilipidemic potential effects of Ganfule capsules in nonalcoholic fatty liver disease., PMID:39113948
ZMYND12 serves as an IDAd subunit that is essential for sperm motility in mice., PMID:39066891
Rare correlation of somatic PRKACA mutations with pregnancy-associated aldosterone- and cortisol-producing adenomas: a case report and literature review., PMID:39010034
The clinical characteristics and pathogenic variants of primary pigmented nodular adrenocortical disease in 210 patients: a systematic review., PMID:39006359
Mechanism of action of the Banxia-Xiakucao herb pair in sleep deprivation: New comprehensive evidence from network pharmacology, transcriptomics and molecular biology experiments., PMID:38986753
Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway., PMID:38908492
Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB1., PMID:38888469
Predictive Analysis of Yi-Gai-San's Multifaceted Mechanisms for Tremor-dominant Parkinson's Disease via Network Pharmacology and Molecular Docking Validation., PMID:38879763
Overexpression of olfactory receptor 78 ameliorates brain injury in cerebral ischaemia-reperfusion rats by activating Prkaca-mediated cAMP/PKA-MAPK pathway., PMID:38856956
PRKACA/PRKACB Fusions in Pancreatobiliary Intraductal Oncocytic Papillary Neoplasms Including Those With Atypical Morphology: An Analysis of 22 Cases Expanding Morphologic Spectrum., PMID:38841868
Phloretin inhibits transmissible gastroenteritis virus proliferation via multiple mechanisms., PMID:38814698
Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification., PMID:38675723
FusionVAC22_01: a phase I clinical trial evaluating a DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocellular carcinoma and other tumor entities carrying the oncogenic driver fusion., PMID:38606105
Ex vivo liver resection and auto-transplantation and special systemic therapy in perihilar cholangiocarcinoma treatment., PMID:38577079
Accurate network pharmacology and novel ingredients formula of herbal targeting estrogen signaling for psoriasis intervention., PMID:38554853
For research use only. Not for human or drug use.
