Catalog No.
YHK46201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn72-Lys149
Predicted molecular weight
22.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96BK5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pin2-interacting protein X1, LPTS, TRF1-interacting protein 1, Liver-related putative tumor suppressor, PIN2/TERF1-interacting telomerase inhibitor 1, LPTL, PINX1, Protein 67-11-3
SOX7: Autism associated gene identified by analysis of multi-Omics data., PMID:40373085
PinX1 plays multifaceted roles in human cancers: a review and perspectives., PMID:39550726
Preparation and anticancer activity of telomerase inhibitor TAT-LPTS39 polypeptide., PMID:39430831
PINX1 loss confers susceptibility to PARP inhibition in pan-cancer cells., PMID:39174499
Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer., PMID:38431575
PinX1-Promoted Autophagy Inhibits Cell Proliferation and Induces Cell Apoptosis by Inhibiting the NF-κB/p65 Signaling Pathway in Nasopharyngeal Carcinoma., PMID:37664923
SOX7: Autism Associated Gene Identified by Analysis of Multi-Omics Data., PMID:37292933
Inhibition Mechanism of PinX1 Gene on Cancer Stem Cells of Nasopharyngeal Carcinoma., PMID:37114251
[Retracted] Pin2/TRF1‑binding protein X1 inhibits colorectal cancer cell migration and invasion in vitro and metastasis in vivo via the nuclear factor‑κB signaling pathway., PMID:36633142
Different Approaches for the Profiling of Cancer Pathway-Related Genes in Glioblastoma Cells., PMID:36142793
Hesperidin Inhibits Lung Cancer In Vitro and In Vivo Through PinX1., PMID:35847001
UTP14A, DKC1, DDX10, PinX1, and ESF1 Modulate Cardiac Angiogenesis Leading to Obesity-Induced Cardiac Injury., PMID:35734237
Knockout of Shelterin subunit genes in zebrafish results in distinct outcomes., PMID:35667242
PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis., PMID:34657040
Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations., PMID:34337078
Telomere shortening and expression of TRF1 and TRF2 in uterine leiomyoma., PMID:34184077
UTMOST, a single and cross-tissue TWAS (Transcriptome Wide Association Study), reveals new ASD (Autism Spectrum Disorder) associated genes., PMID:33931583
Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity., PMID:33819185
Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms., PMID:33647521
Whole exome sequencing identifies the novel putative gene variants related with type 2 diabetes in Mizo population, northeast India., PMID:33059026
The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase., PMID:32882145
PinX1t, a Novel PinX1 Transcript Variant, Positively Regulates Cardiogenesis of Embryonic Stem Cells., PMID:32157956
Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting., PMID:32028978
PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway., PMID:31254127
The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation., PMID:31210926
Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development., PMID:31027734
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes., PMID:30510157
The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways., PMID:30138944
Prognostic and Clinicopathological Value of PINX1 in Various Human Tumors: A Meta-Analysis., PMID:30079348
The clinical significance of PINX1 expression in papillary thyroid carcinoma., PMID:30026037
Pin2/TRF1‑binding protein X1 inhibits colorectal cancer cell migration and invasion in vitro and metastasis in vivo via the nuclear factor‑κB signaling pathway., PMID:30015978
Efficient expression of recombinant human telomerase inhibitor 1 (hPinX1) in Pichia pastoris., PMID:29958061
PINX1 and TERT Are Required for TNF-α-Induced Airway Smooth Muscle Chemokine Gene Expression., PMID:29305433
Identifying the biomarker potential of telomerase activity and shelterin complex molecule, telomeric repeat binding factor 2 (TERF2), in multiple myeloma., PMID:29043869
NF-κB potentiates tumor growth by suppressing a novel target LPTS., PMID:29017500
PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration., PMID:28815183
Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma., PMID:28693215
Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer., PMID:28586040
The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway., PMID:28372542
Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity., PMID:28255170
Enterovirus 71 3C Promotes Apoptosis through Cleavage of PinX1, a Telomere Binding Protein., PMID:27847364
PinX1: structure, regulation and its functions in cancer., PMID:27556185
PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis., PMID:27536146
Association of PINX1 but not TEP1 Polymorphisms with Progression to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection., PMID:27221889
REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype., PMID:27212034
Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy., PMID:26900348
[Influence and mechanism of PinX1 gene on the chemotherapy sensitivity of nasopharyngeal carcinoma cells in response to Cisplatin]., PMID:26710702
Suppression of PinX1 resulted in telomere dysfunction and enhanced radiosensitivity in osteosarcoma cell lines., PMID:26458319
PinX1 is up-regulated and associated with poor patients' survival in gliomas., PMID:26261583
Decreased expression of PinX1 protein predicts poor prognosis of colorectal cancer patients receiving 5-FU adjuvant chemotherapy., PMID:26211574
For research use only. Not for human or drug use.
