Catalog No.
YHK46001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser236-Gln274
Predicted molecular weight
32.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96RD7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MRS1, Pannexin-1, PANX1
Pannexin-1 Aggravates Inflammatory Bowel Disease via Unbalancing Macrophage Polarisation and Triggering Ferroptosis in Mice., PMID:40488292
Synthesis of 3-Carboxy-6-sulfamoylquinolones and Mefloquine-Based Compounds as Panx1 Blockers: Molecular Docking, Electrophysiological and Cell Culture Studies., PMID:40430343
ATP-release pannexin channels are gated by lysophospholipids., PMID:40309905
Pannexin 1 channels: A bridge between synaptic plasticity and learning and memory processes., PMID:40274202
Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury., PMID:40241514
Analysis of the Relationship Between NLRP3 and Alzheimer's Disease in Oligodendrocytes based on Bioinformatics and In Vitro Experiments., PMID:40207815
Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis., PMID:40128095
Ferroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease., PMID:40084946
Purinergic System Transcript Changes in the Dorsolateral Prefrontal Cortex in Suicide and Major Depressive Disorder., PMID:40076453
Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca2+/CaMKII/pannexin 1-dependent signaling., PMID:39990207
Role of shear stress-induced red blood cell released ATP in atherosclerosis., PMID:39982440
PANX1 hexamers work but cells prefer heptamers., PMID:39907692
Divergent sex-specific pannexin-1 mechanisms in microglia and T cells underlie neuropathic pain., PMID:39892387
DAMPs prognostic signature predicts tumor immunotherapy, and identifies immunosuppressive mechanism of pannexin 1 channels in pancreatic ductal adenocarcinoma., PMID:39882247
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma., PMID:39786847
Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice., PMID:39775604
Connexin 43 and Pannexin 1 hemichannels as endogenous regulators of innate immunity in sepsis., PMID:39763679
Novel Naphthyridones Targeting Pannexin 1 for Colitis Management., PMID:39739600
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers., PMID:39704698
[Research progress on biomarkers of sepsis-associated acute kidney injury]., PMID:39697031
The C-terminal activating domain promotes pannexin 1 channel opening., PMID:39671183
N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats., PMID:39630026
Propofol Triggers Cell Death in Lung Cancer Cells by Increasing PANX1 Expression, Activating the Mitochondrial Cell Death Pathway, and Enhancing ROS Levels., PMID:39600278
Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma., PMID:39560179
Pannexin-1 regulation of ATP release promotes the invasion of pituitary adenoma., PMID:39527372
Blocking donor liver Pannexin 1 channels facilitates mitochondria protection during liver transplantation., PMID:39481542
miR-224-5p alleviates preeclampsia-like mouse symptoms by targeting PANX1 to inhibit ferroptosis in trophoblast cells., PMID:39426351
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma., PMID:39372769
Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1-/- Mice., PMID:39334824
GWAS shows the genetics behind cell-free DNA and highlights the importance of p.Arg206Cys in DNASE1L3 for non-invasive testing., PMID:39331505
Novel Pannexin 1 isoform is increased in cancer., PMID:39314291
The Ethanolic Extract of Polygala paniculata L. Blocks Panx1 Channels and Reduces Ischemic Brain Infarct in a Dose- and Sex-Dependent Way., PMID:39271622
Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity., PMID:39264228
A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility., PMID:39232764
HuMSC-EVs Protect Endothelial Cells Against Hypoxia/Reoxygenation Injury by Inhibiting the Pannexin 1/p38-MAPK Pathway., PMID:39147615
Diverse calcium signaling profiles regulate migratory behavior in avascular wound healing and aberrant signal hierarchy occurs early in diabetes., PMID:39129489
Novel genetic variants in the NLRP3 inflammasome-related PANX1 and APP genes predict survival of patients with hepatitis B virus-related hepatocellular carcinoma., PMID:39090420
Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex-dependent manner., PMID:39085909
Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry., PMID:39048565
Pannexin1 Mediates Early-Life Seizure-Induced Social Behavior Deficits., PMID:39024558
The emerging role of Panx1 as a potential therapeutic target for chronic pain., PMID:38970139
Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy., PMID:38957990
PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis., PMID:38937853
Pannexin-1 expression in tumor cells correlates with colon cancer progression and survival., PMID:38897345
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death., PMID:38880128
Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression., PMID:38867288
Ca2+ permeation through C-terminal cleaved, but not full-length human Pannexin1 hemichannels, mediates cell death., PMID:38861601
Potentially functional variants of CHMP4A and PANX1 in the pyroptosis-related pathway predict survival of patients with non-oropharyngeal head and neck squamous cell carcinoma., PMID:38860607
Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309., PMID:38780416
Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway., PMID:38734063
For research use only. Not for human or drug use.
