Catalog No.
YHB56801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu231-Thr426
Predicted molecular weight
24.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95202
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LETM1, Leucine zipper-EF-hand-containing transmembrane protein 1, Mitochondrial proton/calcium exchanger protein
Mitochondrial calcium homeostasis mediated by estradiol contributes to atrial fibrillation protection., PMID:40414005
Integrative proximal-ubiquitomics profiling for deubiquitinase substrate discovery applied to USP30., PMID:40328249
Mdm38/LETM1 couples ion homeostasis and proteostatic mechanisms in the inner mitochondrial membrane., PMID:39975406
The apo LETM1 F-EF-hand adopts a closed conformation that underlies a multi-modal sensory role in mitochondria., PMID:39927520
Compound K promotes thermogenic signature and mitochondrial biogenesis via the UCP1-SIRT3-PGC1α signaling pathway., PMID:39799670
A familial chromosome 4p16.3 terminal microdeletion that does not cause Wolf-Hirschhorn (4p-) syndrome., PMID:39509040
The mysteries of LETM1 pleiotropy., PMID:39481506
Calcium signaling in mitochondrial intermembrane space., PMID:39392359
An AI-informed NMR structure reveals an extraordinary LETM1 F-EF-hand domain that functions as a two-way regulator of mitochondrial calcium., PMID:39317198
Dissecting structure and function of the monovalent cation/H+ antiporters Mdm38 and Ylh47 in Saccharomyces cerevisiae., PMID:39082862
Avian pathogenic Escherichia coli T6SS effector protein Hcp2a causes mitochondrial dysfunction through interaction with LETM1 protein in DF-1 cells., PMID:38367471
Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma., PMID:38292199
Cristae shaping and dynamics in mitochondrial function., PMID:38197774
LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis., PMID:37769890
Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice., PMID:37353518
The Mba1 homologue of Trypanosoma brucei is involved in the biogenesis of oxidative phosphorylation complexes., PMID:36829306
TMBIM5 is the Ca2+ /H+ antiporter of mammalian mitochondria., PMID:36321428
Biochemical properties of H+-Ca2+-exchanger in the myometrium mitochondria., PMID:36176920
Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling., PMID:36056285
Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement., PMID:36055214
Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron-derived extracellular vesicles of early schizophrenia., PMID:35867070
High Expression of TMEM33 Predicts Poor Prognosis and Promotes Cell Proliferation in Cervical Cancer., PMID:35832191
The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish., PMID:35697381
Emerging role of LETM1/GRP78 axis in lung cancer., PMID:35680871
Transcriptome analysis of the gills of Eriocheir sinensis provide novel insights into the molecular mechanisms of the pH stress response., PMID:35598683
Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction., PMID:35563877
Mitochondrial LETM1 drives ionic and molecular clock rhythms in circadian pacemaker neurons., PMID:35545046
Mitochondrial protein LETM1 and its-mediated CTMP are potential therapeutic targets for endometrial cancer., PMID:35324530
SARS-CoV-2 and Mitochondrial Proteins in Neural-Derived Exosomes of COVID-19., PMID:35285072
Lack of TRPV1 aggravates obesity-associated hypertension through the disturbance of mitochondrial Ca2+ homeostasis in brown adipose tissue., PMID:35043013
ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly., PMID:34936866
Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1., PMID:34910916
Mitochondrial calcium exchange in physiology and disease., PMID:34698550
LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes., PMID:34669999
LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14)., PMID:34605738
Editorial: Mitochondrial Exchangers and Transporters in Cell Survival and Death., PMID:34566705
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder., PMID:34471251
Trypanosoma cruzi Letm1 is involved in mitochondrial Ca2+ transport, and is essential for replication, differentiation, and host cell invasion., PMID:34085343
Epigenetic changes related to glucose metabolism in type 1 diabetes after BCG vaccinations: A vital role for KDM2B., PMID:33933315
LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling., PMID:33815143
The leucine zipper EF-hand containing transmembrane protein-1 EF-hand is a tripartite calcium, temperature, and pH sensor., PMID:33576522
LETM1 Knockdown Promotes Autophagy and Apoptosis Through AMP-Activated Protein Kinase Phosphorylation-Mediated Beclin-1/Bcl-2 Complex Dissociation in Hepatocellular Carcinoma., PMID:33552978
Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics., PMID:33316420
Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species-induced autophagy., PMID:33314691
Clinical and genetic characterization of ten Egyptian patients with Wolf-Hirschhorn syndrome and review of literature., PMID:33217222
Total Matrix Ca2+ Modulates Ca2+ Efflux via the Ca2+/H+ Exchanger in Cardiac Mitochondria., PMID:33041851
Whole‑exome sequencing identifies a novel mutation of SLC20A2 (c.C1849T) as a possible cause of hereditary multiple exostoses in a Chinese family., PMID:32705272
MiR-613 blocked the progression of cervical cancer by targeting LETM1., PMID:32633345
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway., PMID:32595998
Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Is a Potential Prognostic Biomarker and Promotes Cell Progression in Prostate Cancer., PMID:32184668
For research use only. Not for human or drug use.
