Catalog No.
YHK45801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg61-Lys403
Predicted molecular weight
40.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NEZ5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FBX22, F-box protein FBX22p44, FBXO22, F-box only protein 22
SDCBP/Syntenin-1 stabilizes BACH1 by disassembling the SCFFBXO22-BACH1 complex in triple-negative breast cancer., PMID:40263598
F-box protein 22: A prognostic biomarker for colon cancer associated with immune infiltration and chemotherapy resistance., PMID:40235877
FBXO22 deficiency defines a pleiotropic syndrome of growth restriction and multi-system anomalies associated with a unique epigenetic signature., PMID:40215970
Implications of frequent hitter E3 ligases in targeted protein degradation screens., PMID:39870762
Ribosomal protein L6 suppresses hepatocellular carcinoma by modulating FBXO22-mediated p53 degradation., PMID:39842528
FBXO22 promotes HCC angiogenesis and metastasis via RPS5/AKT/HIF-1α/VEGF-A signaling axis., PMID:39809956
Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response., PMID:39758820
Dual BACH1 regulation by complementary SCF-type E3 ligases., PMID:39657677
Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress., PMID:39504958
Shenqifuzheng injection inhibits lactic acid-induced cisplatin resistance in NSCLC by affecting FBXO22/p53 axis through FOXO3., PMID:39487426
FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR., PMID:39485803
E3 ubiquitin ligase FBXO22 inhibits SARS-CoV-2 replication via promoting proteasome-dependent degradation of NSP5., PMID:39223933
FBXO22 promotes osteosarcoma progression via regulation of FOXO1 for ubiquitination and degradation., PMID:39153212
Recruitment of FBXO22 for targeted degradation of NSD2., PMID:38965384
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation., PMID:38965383
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation., PMID:38926334
Distinct Perception Mechanisms of BACH1 Quaternary Structure Degrons by Two F-box Proteins under Oxidative Stress., PMID:38895309
E3 ligase FBXO22 is not significant for spermatogenesis and male fertility in mice., PMID:38883371
TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22., PMID:38673728
FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation., PMID:38519492
Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis., PMID:38296976
Potential role of Fbxo22 in resistance to endocrine therapy in breast cancer with invasive lobular carcinoma., PMID:38180699
An impaired ubiquitin-proteasome system increases APOBEC3A abundance., PMID:38155930
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination., PMID:38056426
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency., PMID:37979583
Recruitment of FBXO22 for Targeted Degradation of NSD2., PMID:37961297
A CRISPR activation screen identifies FBXO22 as an E3 ligase supporting targeted protein degradation., PMID:37745578
ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis., PMID:37519006
FBXO22 inhibits proliferation and metastasis of cervical cancer cells by mediating ubiquitination-dependent degradation of GAK., PMID:37442264
FBXO22 Mediates the NGF/TRKA Signaling Pathway in Bone Metastases in Prostate Cancer., PMID:37301536
FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia., PMID:36774506
FBXO22 Accelerates Pancreatic Cancer Growth by Deactivation of the Hippo Pathway via Destabilizing LATS2., PMID:36515852
Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice., PMID:36425318
The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families., PMID:36344539
Fbxo22 promotes cervical cancer progression via targeting p57Kip2 for ubiquitination and degradation., PMID:36127346
Fbxo22 inhibits metastasis in triple-negative breast cancer through ubiquitin modification of KDM5A and regulation of H3K4me3 demethylation., PMID:36112263
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1., PMID:36084789
Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study., PMID:36068491
Host F-Box Protein 22 Enhances the Uptake of Brucella by Macrophages and Drives a Sustained Release of Proinflammatory Cytokines through Degradation of the Anti-Inflammatory Effector Proteins of Brucella., PMID:35420446
Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22., PMID:35141150
Comprehensive Analysis of Expression, Prognostic Value, and Immune Infiltration for Ubiquitination-Related FBXOs in Pancreatic Ductal Adenocarcinoma., PMID:35046938
FBXO22 Promotes Growth and Metastasis and Inhibits Autophagy in Epithelial Ovarian Cancers via the MAPK/ERK Pathway., PMID:34950036
A heme-regulatable chemodynamic nanodrug harnessing transcription factor Bach1 against lung cancer metastasis., PMID:34863556
The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage., PMID:34795058
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis., PMID:34215846
FBXO22, ubiquitination degradation of PHLPP1, ameliorates rotenone induced neurotoxicity by activating AKT pathway., PMID:34182063
[Mechanisms underlying BACH-induced metastases of lung adenocarcin]., PMID:33908860
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis., PMID:33706682
Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer., PMID:33622332
Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-throughput Sequencing., PMID:33428145
For research use only. Not for human or drug use.
