Catalog No.
YHG69801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys21-Ile63
Predicted molecular weight
32.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14061
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytochrome c oxidase copper chaperone, COX17
Effects of Dietary Copper Sources and Levels on Liver Copper Metabolism and the Expression of Transporters in Growing Pigs., PMID:40003008
Effects of Gonadotropin-Releasing Hormone Analogues on Ovarian Function and Embryogenesis: A Cyclophosphamide-Induced Mouse Model Study., PMID:39973029
Evaluation of GFM1 mutations pathogenicity through in silico tools, RNA sequencing and mitophagy pahtway in GFM1 knockout cells., PMID:39952508
Nitric oxide enhances copper tolerance by regulating cell wall composition and copper transporting-related transcripts in cotton roots., PMID:39952160
Roles of Copper Transport Systems Members in Breast Cancer., PMID:39676279
Copper homeostasis and neurodegenerative diseases., PMID:39589160
Novel fungicide and neonicotinoid insecticide impair flight behavior in pollen foraging honey bees, Apis mellifera., PMID:39354118
Curcumin suppresses copper accumulation in non-small cell lung cancer by binding ATOX1., PMID:39169392
Deregulation of oxidative phosphorylation pathways in embryos derived in vitro from prepubertal and pubertal heifers based on whole-transcriptome sequencing., PMID:38914933
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17., PMID:38091880
MKT1 alleles regulate stress responses through posttranscriptional modulation of Puf3 targets in budding yeast., PMID:37990816
MOF acetylates COX17 to preserve functional mitochondria: a KAT with two lives., PMID:37945742
Discovery of an unusual copper homeostatic mechanism in yeast cells respiring on minimal medium and an unexpectedly diverse labile copper pool., PMID:37944620
COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function., PMID:37813994
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity., PMID:37217601
Copper and cuproptosis-related genes in hepatocellular carcinoma: therapeutic biomarkers targeting tumor immune microenvironment and immune checkpoints., PMID:37153542
Copper metabolism in cell death and autophagy., PMID:37055935
Identify Biomarkers and Design Effective Multi-Target Drugs in Ovarian Cancer: Hit Network-Target Sets Model Optimizing., PMID:36552360
2,3',4,4',5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress., PMID:36450500
Integrated Multi-Omic Characterization of the Detachment Process of Adherent Vero Cells with Animal-Based and Animal-Origin-Free Enzymes., PMID:36359792
Pan-cancer genetic analysis of cuproptosis and copper metabolism-related gene set., PMID:36276096
Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance., PMID:36208295
Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate., PMID:35886903
Integration of transcriptomic and metabolomic reveals metabolic pathway alteration in earthworms (Eisenia fetida) under copper exposure., PMID:35753647
Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage., PMID:35148806
Metallothionein immunohistochemistry has high sensitivity and specificity for detection of Wilson disease., PMID:34934154
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis., PMID:34911956
Transcriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones., PMID:34468270
Impact of Cell Culture and Copper Dose on Gene Expression in Bovine Liver., PMID:34331662
Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation., PMID:34101239
Knockdown of Gastrin Promotes Apoptosis of Gastric Cancer Cells by Decreasing ROS Generation., PMID:33937399
Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus., PMID:33878312
iTRAQ-based proteomic analysis of the hippocampus of pentylenetetrazole-kindled epileptic rats., PMID:33316100
Copper metabolism in Saccharomyces cerevisiae: an update., PMID:33128172
The neonicotinoid thiacloprid causes transcriptional alteration of genes associated with mitochondria at environmental concentrations in honey bees., PMID:32823041
Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation., PMID:32745624
The molecular mechanisms of copper metabolism and its roles in human diseases., PMID:32506322
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal., PMID:32416059
Transcriptomic responses to pollution in natural riverine environment in Rita rita., PMID:32325295
Associations of polymorphisms in LOXL1 and copper chaperone genes with pseudoexfoliation-syndrome-related cataract in a Chinese Uygur population., PMID:32253563
Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis., PMID:32169084
Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells., PMID:32107448
Stable COX17 Downregulation Leads to Alterations in Mitochondrial Ultrastructure, Decreased Copper Content and Impaired Cytochrome c Oxidase Biogenesis in HEK293 Cells., PMID:31903891
Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure., PMID:31821401
Copper nanoparticles induce zebrafish intestinal defects via endoplasmic reticulum and oxidative stress., PMID:31820776
Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome., PMID:31682224
Transcriptional profiles and copper stress responses in zebrafish cox17 mutants., PMID:31662245
Biopesticide spinosad induces transcriptional alterations in genes associated with energy production in honey bees (Apis mellifera) at sublethal concentrations., PMID:31202068
A Large-Scale Genome-Wide Association Study in U.S. Holstein Cattle., PMID:31139206
Excess copper promotes photoinhibition and modulates the expression of antioxidant-related genes in Zostera muelleri., PMID:30553148
For research use only. Not for human or drug use.
