Catalog No.
YHH77301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn187
Predicted molecular weight
23.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q4G0J3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
La ribonucleoprotein domain family member 7, La-related protein 7, hLARP7, P-TEFb-interaction protein for 7SK stability, LARP7, PIP7S
MePCE promotes homologous recombination through coordinating R-loop resolution at DNA double-stranded breaks., PMID:40411785
Liquid-liquid phase separation of LARP7 restrains HIV-1 replication., PMID:40113991
Glucose-regulating hydrogel for immune modulation and angiogenesis through metabolic reprogramming and LARP7-SIRT1 pathway in infected diabetic wounds., PMID:39951832
Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors., PMID:39933393
The effect of LARP7 on gene expression during osteogenesis., PMID:39804499
LARP7 is required for sex chromosome silencing during meiosis in mice., PMID:39637191
Exome Sequencing Detects Uniparental Disomy of Chromosome 4 Revealing a LARP7 Pathogenic Variant Responsible for Alazami Syndrome: A Case Report., PMID:39417555
LARP7 Contributes to Glucose-Induced Cardiac Dysfunction, Apoptosis and Fibrosis by Inhibiting the Degradation of STING., PMID:39082350
LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis., PMID:39009594
Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition., PMID:39002485
LARP7 overexpression alleviates aortic senescence and atherosclerosis., PMID:38818612
LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice., PMID:37937491
The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA., PMID:37403782
Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR., PMID:37330293
Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle-yak hybrids., PMID:37050850
LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway., PMID:36617833
Multiple RNA-binding proteins associated with long interspersed element-1 encoded ORF1p are targeted by the autoimmune response in systemic lupus erythematosus., PMID:39606792
Involvement of LARP7 in Activation of SIRT1 to Inhibit NF-κB Signaling Protects Microglia from Acrylamide-Induced Neuroinflammation., PMID:36550222
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma., PMID:36434634
A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing., PMID:36304109
[Genetic diagnosis of a Chinese pedigree affected with Alazami syndrome]., PMID:36184089
Expanding the Phenotypic Spectrum of Alazami Syndrome: Two Unrelated Spanish Families., PMID:36126956
Further phenotypic delineation of Alazami syndrome., PMID:35567578
Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP., PMID:35320752
The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme., PMID:35277511
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability., PMID:35274760
A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis., PMID:35217638
LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity., PMID:34818543
The BRCA1/BARD1 ubiquitin ligase and its substrates., PMID:34591954
[7SK truncation at 128-179 nt suppresses embryonic stem cell proliferation in vitro by downregulating CDC6]., PMID:34549701
LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28., PMID:34503347
An alternative D. melanogaster 7SK snRNP., PMID:34461828
Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies., PMID:34107850
The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming., PMID:33852864
LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis., PMID:33663221
Interaction of 7SK with the Smn complex modulates snRNP production., PMID:33627647
Alazami syndrome: Report of three Indian patients with phenotypic spectrum from adolescence to adulthood., PMID:33569879
LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization., PMID:33522422
Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism., PMID:33356342
The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1., PMID:33292040
Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins., PMID:33131423
Alazami syndrome: Phenotypic expansion and clinical resemblance to Smith-Lemli-Opitz syndrome., PMID:32888391
Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency., PMID:32851167
L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis., PMID:32726637
Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism., PMID:32401147
Compound Phenotype Due to Recessive Variants in LARP7 and OTOG Genes Disclosed by an Integrated Approach of SNP-Array and Whole Exome Sequencing., PMID:32244554
The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness., PMID:32017898
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice., PMID:32017896
Alazami syndrome: the first case of papillary thyroid carcinoma., PMID:31656314
de novo MEPCE nonsense variant associated with a neurodevelopmental disorder causes disintegration of 7SK snRNP and enhanced RNA polymerase II activation., PMID:31467394
For research use only. Not for human or drug use.
