Catalog No.
PHC25401
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ANXA2 (Met1-Asp339).
Tested applications
ELISA: 1:2000-1:8000, IHC: 1:50-1:100, WB: 1:500-1:4000
Target
Lipocortin II,Annexin A2,Calpactin-1 heavy chain,PAP-IV,p36,CAL1H,Calpactin I heavy chain,ANX2,ANX2L4,Protein I,Annexin-2,LPC2D,Annexin II,ANXA2,Placental anticoagulant protein IV,Chromobindin-8
Concentration
0.15 mg/ml
Purification
Purified by antigen affinity column.
Accession
P07355
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
E53, E96, D162, E247 and D322 in Ca2+-binding domains of annexin A2 are essential for regulating intracellular [Ca2+] and crystal adhesion to renal cells via ERK1/2 and JNK signaling pathways., PMID:40189002
miRNome analysis reveals mir-155-5p as a protective factor to dengue infection in a resistant Thai cohort., PMID:39976655
Heterologous expression, purification and generation of specific antibodies for Annexin A8., PMID:39674528
Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling., PMID:39572752
Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice., PMID:39384746
Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection., PMID:38913740
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice., PMID:38401303
Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis., PMID:38092984
Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate., PMID:37231059
Hemocompatible Functionalized Hydrogen Substituted Graphdiyne Based Highly Durable Biosensor for Liver Cancer Detection., PMID:37195122
Mechanisms Limiting Renal Tissue Protection and Repair in Glomerulonephritis., PMID:37176025
Blockade of Annexin A2 Prevents Early Microvasculopathy in Murine Models of Diabetic Retinopathy., PMID:37103008
Cell Entry of Avian Reovirus Modulated by Cell-Surface Annexin A2 and Adhesion G Protein-Coupled Receptor Latrophilin-2 Triggers Src and p38 MAPK Signaling Enhancing Caveolin-1- and Dynamin 2-Dependent Endocytosis., PMID:37097149
Annexin A2 regulates Mycoplasma bovis adhesion and invasion to embryo bovine lung cells affecting molecular expression essential to inflammatory response., PMID:36159852
2D transparent few-layered hydrogen substituted graphdiyne nano-interface for unprecedented ultralow ANXA2 cancer biomarker detection., PMID:35696865
Teriflunomide normalizes anti-anxiety effect in anti-ANXA2 APS mice model teriflunomide in anti-ANXA2 mice model., PMID:35575144
Identification of ANXA2 on epithelial cells as a new receptor for secretory IgA using immunoprecipitation and mass spectrometry., PMID:35511485
Annexin A2: The diversity of pathological effects in tumorigenesis and immune response., PMID:35474212
A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors., PMID:34715620
Annexin A2-Mediated Internalization of Staphylococcus aureus into Bovine Mammary Epithelial Cells Requires Its Interaction with Clumping Factor B., PMID:34683411
Clinical Limitations of Tissue Annexin A2 Level as a Predictor of Postoperative Overall Survival in Patients with Hepatocellular Carcinoma., PMID:34575275
Gefitinib Combined with Cetuximab for the Treatment of Lung Adenocarcinoma Harboring the EGFR-Intergenic Region (SEC61G) Fusion and EGFR Amplification., PMID:34342091
Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients., PMID:34244321
The association between Annexin A2 and epithelial cell adhesion molecule in breast cancer cells., PMID:34240826
The Bioactive Peptide SL-13R Expands Human Umbilical Cord Blood Hematopoietic Stem and Progenitor Cells In Vitro., PMID:33915948
Human colorectal cancer-associated carbohydrate antigen on annexin A2 protein., PMID:33904933
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways., PMID:33903672
Annexin A2 Flop-Out Mediates the Non-Vesicular Release of DAMPs/Alarmins from C6 Glioma Cells Induced by Serum-Free Conditions., PMID:33807671
Autoantibodies to Annexin A2 and cerebral thrombosis: Insights from a mouse model., PMID:33554716
DNA damage in human glomerular endothelial cells induces nodular glomerulosclerosis via an ATR and ANXA2 pathway., PMID:33335142
Alterations in proteome of human sclera associated with primary open-angle glaucoma involve proteins participating in regulation of the extracellular matrix., PMID:32913388
Important role of annexin A2 (ANXA2) in new blood vessel development in vivo and human triple negative breast cancer (TNBC) growth., PMID:32866522
The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer., PMID:32671503
Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway., PMID:32268913
Chemotherapy combined with bevacizumab for the treatment of advanced lung adenocarcinoma cancer harboring EGFR-ANXA2, EGFR-RAD51, ATR and BRCA2 mutations: A case report., PMID:31865638
Autoimmune-Mediated Retinopathy in CXCR5-Deficient Mice as the Result of Age-Related Macular Degeneration Associated Proteins Accumulation., PMID:31474986
In vivo surveillance and elimination of teratoma-forming human embryonic stem cells with monoclonal antibody 2448 targeting annexin A2., PMID:31388993
Autoantibody-targeted TAAs in pancreatic cancer: A comprehensive analysis., PMID:31255446
A new role for host annexin A2 in establishing bacterial adhesion to vascular endothelial cells: lines of evidence from atomic force microscopy and an in vivo study., PMID:31253864
Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice., PMID:31163177
Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies., PMID:31113479
Prevalence of anti-S100A10 antibodies in antiphospholipid syndrome patients., PMID:31059997
Anxa2- and Ctsd-knockout CHO cell lines to diminish the risk of contamination with host cell proteins., PMID:30972970
Reciprocal regulation of pro-inflammatory Annexin A2 and anti-inflammatory Annexin A1 in the pathogenesis of rheumatoid arthritis., PMID:30426384
Targeting of embryonic annexin A2 expressed on ovarian and breast cancer by the novel monoclonal antibody 2448., PMID:29568351
Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus., PMID:28893180
Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion in acute promyelocytic leukemia., PMID:28687976
Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients., PMID:28396717
Mechanisms of Cellular Activation in the Antiphospholipid Syndrome., PMID:28166601
Complex Roles of Annexin A2 in Host Blood-Brain Barrier Invasion by Cryptococcus neoformans., PMID:28130864
For research use only. Not for human or drug use.
