Catalog No.
YHE70801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly126
Predicted molecular weight
15.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49773
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histidine triad nucleotide-binding protein 1, HINT, Adenosine 5'-monophosphoramidase, HINT1, PKCI-1, PRKCNH1, Protein kinase C inhibitor 1, Protein kinase C-interacting protein 1, PKCI1
Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores., PMID:40340313
HINT1 aggravates aortic aneurysm by targeting ITGA6/FAK axis in vascular smooth muscle cells., PMID:40198125
Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy., PMID:40133424
Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer., PMID:40033163
Hereditary, non HINT1 related, axonal neuropathy with neuromyotonia., PMID:40009145
HINT1 Inhibitors as Selective Modulators of MOR-NMDAR Cross-Regulation and Non-Opioid Analgesia., PMID:39913175
HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis., PMID:39909188
Delineating the genetic landscape of Charcot-Marie-tooth disease in Türkiye: Distinct distribution, rare phenotypes, and novel variants., PMID:39776111
Small Complex Rearrangement in HINT1-Related Axonal Neuropathy., PMID:39596683
HINT1 promotes neuronal apoptosis and triggers schizophrenia-like behavior in rats., PMID:39426527
Pinpointing Novel Plasma and Brain Proteins for Common Ocular Diseases: A Comprehensive Cross-Omics Integration Analysis., PMID:39408566
Multi-omics analysis to reveal the synergistic mechanism underlying the multiple ingredients of Stephania tetrandra extract on rheumatoid arthritis through the PI3K/Akt signaling pathway., PMID:39221139
HINT1 Gene Polymorphisms, Smoking Behaviour, and Personality Traits: A Haplotype Case-Control Study., PMID:39062900
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 and venous thromboembolism., PMID:38909539
Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis., PMID:38585359
The HINT1 Gene rs2526303 Polymorphism and Its Association with Personality Traits in Cigarette Smokers., PMID:38279213
Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease., PMID:38103512
Histidine Triad Nucleotide-Binding Protein 1 Improves Critical Limb Ischemia by Regulating Mitochondrial Homeostasis., PMID:38068718
Electroacupuncture Exerts Analgesic Effects by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory Pain., PMID:37957422
Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl4-induced liver fibrosis in mice., PMID:37955610
Generalized myokymia, or neuromyotonia, or both in dogs with or without spinocerebellar ataxia., PMID:37905444
The Many Faces of Histidine Triad Nucleotide Binding Protein 1 (HINT1)., PMID:37854629
CBD enhances the cognitive score of adolescent rats prenatally exposed to THC and fine-tunes relevant effectors of hippocampal plasticity., PMID:37583903
Association of the rs3864283 Polymorphism Located in the HINT1 Gene with Cigarette Use and Personality Traits., PMID:37373392
Proteome Analysis of the Antiproliferative Activity of the Novel Chitooligosaccharide-Gallic Acid Conjugate against the SW620 Colon Cancer Cell Line., PMID:37371778
HINT3 suppresses AKT/mTOR signaling pathway activity during breast cancer tumorigenesis through PTEN transcriptional activation., PMID:37203409
HINT1-Associated Axonal Neuropathy with Neuromyotonia., PMID:37148078
Case report: A novel homozygous histidine triad nucleotide-binding protein 1 mutation featuring distal hereditary motor-predominant neuropathy with rimmed vacuoles., PMID:36846110
The oncogenic and immunological roles of histidine triad nucleotide-binding protein 1 in human cancers and their experimental validation in the MCF-7 cell line., PMID:36846002
Prenatal Exposure to Δ9-Tetrahydrocannabinol Affects Hippocampus-Related Cognitive Functions in the Adolescent Rat Offspring: Focus on Specific Markers of Neuroplasticity., PMID:36840014
Redox homeostasis at SAM: a new role of HINT protein., PMID:36520227
HINT1 neuropathy in Lithuania: clinical, genetic, and functional profiling., PMID:36242072
Bioinformatics analysis of diagnostic biomarkers for Alzheimer's disease in peripheral blood based on sex differences and support vector machine algorithm., PMID:36195955
KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design., PMID:36150388
Identification and Validation of Novel Potential Pathogenesis and Biomarkers to Predict the Neurological Outcome after Cardiac Arrest., PMID:35884735
HINT1 neuropathy: Expanding the genotype and phenotype spectrum., PMID:35882622
A novel mutation in HINT1 gene causes autosomal recessive axonal neuropathy with neuromyotonia, effective treatment with carbamazepine and review of the literature., PMID:35767146
USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage., PMID:35605301
Myasthenia gravis coexisting with HINT1-related motor axonal neuropathy without neuromyotonia: a case report., PMID:35501818
Integrated analysis of ceRNA network reveals potential prognostic Hint1-related lncRNAs involved in hepatocellular carcinoma progression., PMID:35241097
Response by Zhang and Ji to Letter Regarding Article, "HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression"., PMID:35188798
Letter by Wang et al Regarding Article, "HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression"., PMID:35188795
Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5'-O-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells., PMID:35054788
HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances., PMID:34995725
Remdesivir: Mechanism of Metabolic Conversion from Prodrug to Drug., PMID:34963432
Neuromuscular hyperexcitability syndromes., PMID:34914668
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside., PMID:34870151
Comparative Proteomic Analysis of HPV(+) Oropharyngeal Squamous Cell Carcinoma Recurrence., PMID:34846153
The impact of genetic variations in sofosbuvir metabolizing enzymes and innate immunity mediators on treatment outcome in HCV-infected patients., PMID:34843922
The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain., PMID:34827679
For research use only. Not for human or drug use.
