Catalog No.
YHH36001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly21-His247
Predicted molecular weight
27.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16740
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Endopeptidase Clp, ATP-dependent Clp protease proteolytic subunit, mitochondrial, CLPP
Dose Optimization of ClpP Agonists Using an In Vitro Microfluidic Perfusion Platform and In Silico Pharmacokinetic-Pharmacodynamic Modeling., PMID:40514581
Methicillin-Resistant Staphylococcus aureus has Phenotypic Variation in mecA Expression that Alters Antibiotic Sensitivity., PMID:40501806
Comparative analyses of the complete chloroplast genomes of four Caragana species, a specific genus distributed in arid and semi-arid area., PMID:40471310
Reduced Expression of UPRmt Proteins HSP10, HSP60, HTRA2, OMA1, SPG7, and YME1L Is Associated with Accelerated Heart Failure in Humans., PMID:40426970
Whole-Genome Sequence Analysis, Probiotic Potential, and Safety Assessment of the Marine Bacterium Paraliobacillus zengyii CGMCC1.16464., PMID:40422792
CLPP Gene Variants Causing Perrault Syndrome Type 3 in Han Chinese Families: A Genotype-Phenotype Study., PMID:40410890
The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in Streptococcus pneumoniae., PMID:40407370
Targeting mitochondrial ClpP: structural insights and therapeutic potential of ClpP agonists in cancer therapy., PMID:40395852
Comparative analysis of complete chloroplast genomes of Cousinia (Asteraceae) species., PMID:40365567
Anti-infective therapy of inhibiting Staphylococcus aureus ClpP by protocatechuic aldehyde., PMID:40334630
UPRmt alleviates bone cancer pain through the restoration of mitochondrial function., PMID:40273969
Mechanism of allosteric activation in human mitochondrial ClpP protease., PMID:40232800
BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain., PMID:40230701
Towards a Survival-Based Cellular Assay for the Selection of Protease Inhibitors in Escherichia coli., PMID:40227283
Gel@CAT-L hydrogel mediates mitochondrial unfolded protein response to regulate reactive oxygen species and mitochondrial homeostasis in osteoarthritis., PMID:40222260
ONC201 exerts oncogenic effects beyond its mitochondria-disturbing role in neuroblastoma subsets., PMID:40210723
The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum., PMID:40192064
Ischemic preconditioning attenuates ischemia/reperfusion-induced acute kidney injury dependent on mitochondrial protease CLPP., PMID:40172021
Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT., PMID:40145650
Enhancing Sonodynamic Therapy in Prostate Cancer: Cavitation-Induced Cytotoxicity and Mitochondrial Unfolded Protein Response Disruption., PMID:40131613
Degradation of Nonribosomal Peptide Synthetase Megasynthetases SrfAA and SrfAB by Acyldepsipeptide-Activated ClpP in Bacillus Subtilis., PMID:40126037
Engineering a New SsrA-Based Degradation Tag (LAA-LAA) and a Bacterial Synthetic Oscillator., PMID:40106229
Proteomic insight into the beneficial effect of mannoproteins on Oenococcus oeni in wine malolactic fermentation., PMID:40086985
MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore., PMID:40086879
Rhein alleviates diabetic cardiomyopathy by inhibiting mitochondrial dynamics disorder, apoptosis and hypertrophy in cardiomyocytes., PMID:40081546
Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation., PMID:40074108
MecA: A Multifunctional ClpP-Dependent and Independent Regulator in Gram-Positive Bacteria., PMID:40070161
The mitochondrial protease ClpP is a promising target for multiple myeloma treatment., PMID:40054785
HAP/ClpP-mediated disaggregation and degradation of Mutant SOD1 aggregates: A potential therapeutic strategy for Amyotrophic lateral sclerosis (ALS)., PMID:40054065
Deciphering the role of SMU.1147 in peptide-mediated signaling and competence in Streptococcus mutans., PMID:40042332
Dynamic Oligomerization Processes of Bacillus subtilis ClpP Protease Induced by ADEP1 Studied with High-Speed Atomic Force Microscopy., PMID:40028094
Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion., PMID:40016670
Production, Purification, and Biochemical Characterization of a Novel ATP-Dependent Caseinolytic Protease from the Marine Bacterium Cobetia amphilecti KMM 296., PMID:40005674
ONC201-Derived Tetrahydropyridopyrimidindiones as Powerful ClpP Protease Activators to Tackle Diffuse Midline Glioma., PMID:39973170
Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma., PMID:39935096
Targeting caseinolytic mitochondrial matrix peptidase, a novel contributor to the pathobiology of high-risk multiple myeloma., PMID:39912779
The complete chloroplast genome and phylogenetic analysis of Emilia prenanthoidea (Asteraceae)., PMID:39912104
Comparative analysis of chloroplast genomes reveals molecular evolution and phylogenetic relationships within the Papilionoideae of Fabaceae., PMID:39910427
Decoding the Chloroplast Genome of Korean endemic plant Acer okamotoanum: Comparative Genomics, Phylogenetic Insights, and Potential for Marker Development., PMID:39907952
Neuroprotective role of Da Qin Jiu decoction in ischemic stroke: Mitochondrial rescue through PI3K/Akt-mediated UPRmt activation., PMID:39894416
Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease., PMID:39879245
Antibodies directed against bacterial antigens in sera of Polish patients with primary biliary cholangitis., PMID:39844835
Neuroendocrine prostate cancer drivers SOX2 and BRN2 confer differential responses to imipridones ONC201, ONC206, and ONC212 in prostate cancer cell lines., PMID:39822524
Sesamin targets ClpP which attenuates virulence of S. aureus and protects mice from fatal pneumonia induced by MRSA., PMID:39805732
Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection., PMID:39760203
Targeting ClpP: Unlocking a novel therapeutic approach of isochlorogenic acid A for methicillin-resistant Staphylococcus aureus-infected osteomyelitis., PMID:39756139
Unraveling the organellar genomic landscape of the therapeutic and entheogenic plant Mimosa tenuiflora: insights into genetic, structural, and evolutionary dynamics., PMID:39738702
Corrigendum to: HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells., PMID:39719882
Hesperetin Increases Lifespan and Antioxidant Ability Correlating with IIS, HSP, mtUPR, and JNK Pathways of Chronic Oxidative Stress in Caenorhabditis elegans., PMID:39684858
For research use only. Not for human or drug use.
