Catalog No.
YHK38101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln55-Asn338
Predicted molecular weight
59.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99571
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Purinergic receptor, P2RX4, P2X4, P2X purinoceptor 4, ATP receptor
Demethylase FTO in the cerebrospinal fluid-contacting nucleus of mice contributes to neuropathic pain via mediating m6A demethylation of P2rx4 mRNA., PMID:40222402
The role and function validation of P2RX4 as a novel cancer biomarker in pan-cancer analysis., PMID:40181033
CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus., PMID:39995666
Hippocampal P2X4 receptor induces type 1 diabetes rats with neuropathic pain through microglial-derived neuroinflammation and neuronal damage., PMID:39993667
Pharmacological inhibition of P2RX4 receptor as a potential therapeutic strategy to prevent intracranial aneurysm formation., PMID:39551461
Revealing the Novel Role of Purinergic Receptor P2X4 in Phagocytic Uptake After Ischemic Stroke., PMID:39344649
The role of P2X4R in regulating CA1 hippocampal synaptic impairment in LPS-induced depression., PMID:39019229
Association of polymorphisms within P2RX4 with type 2 diabetes mellitus: a preliminary case-control study., PMID:38954847
Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction., PMID:38953020
Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching., PMID:38821358
miR-153 promotes neural differentiation by activating the cell adhesion/Ca2+ signaling pathway and targeting ion channel activity in HT-22 cells by bioinformatic analysis., PMID:38694121
Bone marrow plasma cells require P2RX4 to sense extracellular ATP., PMID:38355795
Methods for studying P2X4 receptor ion channels in immune cells., PMID:38311008
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice., PMID:38159160
Calcimycin mediates apoptosis in breast and cervical cancer cell lines by inducing intracellular calcium levels in a P2RX4-dependent manner., PMID:38103757
Distribution of P2Y and P2X purinergic receptor expression within the intestine., PMID:37987757
Epigenetic HDAC5 Inhibitor Reverses Craniofacial Neuropathic Pain in Mice., PMID:37777035
The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer., PMID:37745355
Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma., PMID:37563735
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy., PMID:37471054
Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease., PMID:37145189
P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis., PMID:37085966
Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux., PMID:36807142
RNA-seq reveals that anti-obesity irisin and triiodothyronine (T3) hormones differentially affect the purinergic signaling transcriptomics in differentiated human adipocytes., PMID:36642213
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats., PMID:36529845
Exonic variants of the P2RX7 gene in familial multiple sclerosis., PMID:36470550
P2X receptors: Insights from the study of the domestic dog., PMID:36464207
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation., PMID:36385525
Altered purinergic receptor expression in the frontal cortex in schizophrenia., PMID:36376358
Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation., PMID:35676684
[Interference of P2X4 receptor expression in tumor-associated macrophages suppresses migration and invasion of glioma cells]., PMID:35673908
Blocking connexin 43 and its promotion of ATP release from renal tubular epithelial cells ameliorates renal fibrosis., PMID:35641484
Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury., PMID:35634278
The P2X4 Receptor: Cellular and Molecular Characteristics of a Promising Neuroinflammatory Target., PMID:35628550
Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation., PMID:35610277
P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis., PMID:35594248
Augmentation of Extracellular ATP Synergizes With Chemotherapy in Triple Negative Breast Cancer., PMID:35515134
Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel., PMID:35368676
Activation of P2X4 receptor exacerbates acute brain injury after intracerebral hemorrhage., PMID:35352488
P2X7/P2X4 Receptors Mediate Proliferation and Migration of Retinal Microglia in Experimental Glaucoma in Mice., PMID:35254644
Comparative genomics and selection analysis of Yeonsan Ogye black chicken with whole-genome sequencing., PMID:35134497
Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients., PMID:35091759
Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions., PMID:34996944
[Recent Findings on the Mechanism of Cough Hypersensitivity as a Cause of Chronic Cough]., PMID:34853206
Involvement of the miR-363-5p/P2RX4 Axis in Regulating Schwann Cell Phenotype after Nerve Injury., PMID:34769029
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer., PMID:34652816
The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells., PMID:34548395
[Elucidation of Mast Cell Activation Mechanism Mediated by Purinergic Signaling]., PMID:34471006
lncRNA and mRNA sequencing of the left testis in experimental varicocele rats treated with Morinda officinalis polysaccharide., PMID:34466146
Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats., PMID:34419102
For research use only. Not for human or drug use.
