Catalog No.
YHC90301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile374
Predicted molecular weight
41.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11766
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ADHX, ADH5, FDH, Alcohol dehydrogenase class chi chain, Alcohol dehydrogenase class-3, Alcohol dehydrogenase class-III, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase, FALDH, Glutathione-dependent formaldehyde dehydrogenase, Alcohol dehydrogenase 5
Emerging mechanisms underlying formaldehyde toxicity and response., PMID:40480196
Genetic associations of plasma proteins and breast cancer identify potential therapeutic drug candidates., PMID:40234727
Identification of Biomarkers for Meat Quality in Sichuan Goats Through 4D Label-Free Quantitative Proteomics., PMID:40150416
The difference between young and older ducks: Amino acid, free fatty acid, nucleotide compositions and breast muscle proteome., PMID:39810946
ALDH Enzymes and Hematological Diseases: A Scoping Review of Literature., PMID:39726306
Inhalation exposure to airborne PM2.5 attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor., PMID:39607384
Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of ERO1α and reduces neuronal death in secondary traumatic brain injury., PMID:39566653
The role of S-nitrosoglutathione reductase (GSNOR) in T cell-mediated immunopathology of experimental autoimmune encephalomyelitis (EAE)., PMID:39532197
Melatonin derivative 6a protects Caenorhabditis elegans from formaldehyde neurotoxicity via ADH5., PMID:39127141
ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes., PMID:38944932
S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation., PMID:38901102
Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging., PMID:38894680
Integrated proteogenomic analysis for inherited bone marrow failure syndrome., PMID:38740980
Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight., PMID:38671880
Characteristic phenotypes of ADH5/ALDH2 deficiency during childhood., PMID:38614309
Elevated ADH5 expression suggested better prognosis in kidney renal clear cell carcinoma (KIRC) and related to immunity through single-cell and bulk RNA-sequencing., PMID:38600527
GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14., PMID:38570588
S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens., PMID:38409248
Sterile inflammation induces vasculopathy and chronic lung injury in murine sickle cell disease., PMID:38336101
Comprehensive mRNA and microRNA analysis revealed the effect and response strategy of freshwater fish, grass carp (Ctenopharyngodon idella) under geosmin exposure., PMID:38070413
Mendelian Randomization Identifies Genetically Supported Drug Targets for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia., PMID:38019415
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease., PMID:37700498
Cyclic strain of poly (methyl methacrylate) surfaces triggered the pathogenicity of Candida albicans., PMID:37625677
Supersulfide catalysis for nitric oxide and aldehyde metabolism., PMID:37595031
Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage., PMID:37572579
Class III Alcohol Dehydrogenase Plays a Key Role in the Onset of Alcohol-Related/-Associated Liver Disease as an S-Nitrosoglutathione Reductase in Mice., PMID:37569481
[A new Fanconi anemia-like disorder, aldehyde degradation deficiency syndrome: two defense mechanisms working together for the genome and hematopoiesis]., PMID:37544724
Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation., PMID:37377022
Large-scale rare variant burden testing in Parkinson's disease., PMID:37348876
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner., PMID:37348497
Brain-wide transcriptome-based metabolic alterations in Parkinson's disease: human inter-region and human-experimental model correlations., PMID:36928892
Identification of alternative splicing events related to fatty liver formation in duck using full-length transcripts., PMID:36858953
Morphofunctional State and Circadian Rhythms of the Liver of Female Rats under the Influence of Chronic Alcohol Intoxication and Constant Lighting., PMID:36142658
GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson's disease., PMID:35918012
Mining transcriptomic data to identify Saccharomyces cerevisiae signatures related to improved and repressed ethanol production under fermentation., PMID:35881609
S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia., PMID:35191317
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity., PMID:35136057
In Situ Imaging of Formaldehyde in Live Mice with High Spatiotemporal Resolution Reveals Aldehyde Dehydrogenase-2 as a Potential Target for Alzheimer's Disease Treatment., PMID:34962779
An Atlas of the Quantitative Protein Expression of Anti-Epileptic-Drug Transporters, Metabolizing Enzymes and Tight Junctions at the Blood-Brain Barrier in Epileptic Patients., PMID:34959403
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response., PMID:34819667
Formaldehyde toxicity in age-related neurological dementia., PMID:34798299
ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue., PMID:34788615
[New insights into inherited bone marrow failure syndrome]., PMID:34732617
GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation., PMID:34678655
Hedera rhombea inhibits the biofilm formation of Candida, thereby increases the susceptibility to antifungal agent, and reduces infection., PMID:34614005
HSP60 Regulates Lipid Metabolism in Human Ovarian Cancer., PMID:34557266
[Aldehyde degradation deficiency (ADD) syndrome: discovery of a novel fanconi anemia-like inherited BMF syndrome due to combined ADH5/ALDH2 deficiency]., PMID:34219079
Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration., PMID:33789111
Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth Muscle adh5., PMID:33780653
GSNOR and ALDH2 alleviate traumatic spinal cord injury., PMID:33545099
For research use only. Not for human or drug use.
