Catalog No.
YHA12801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp37-Asn271
Predicted molecular weight
28.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00469
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PLOD2, Lysyl hydroxylase 2, Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, LH2
Comprehensive analysis of blood proteome response to necrotic enteritis in broiler chicken., PMID:40275387
Comprehensive analysis of glycometabolism-related genes reveals PLOD2 as a prognostic biomarker and therapeutic target in gastric cancer., PMID:40229676
Metabolism-related ALDH1B1 acts as potential predictor and therapeutic target for primary gastrointestinal diffuse large B-cell lymphoma., PMID:40216643
The Effect of Platelet-Rich Plasma on Synovial Fibrosis and Cartilage Degeneration in Knee Osteoarthritis., PMID:40114320
Anti-fibrotic effects of thrombin inhibition in systemic sclerosis-associated interstitial lung disease: Proof of concept., PMID:40013233
Knockdown of PLOD2 inhibits pulmonary artery smooth muscle cell glycolysis under chronic intermittent hypoxia via PI3K/AKT signal., PMID:39961468
Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway., PMID:39943705
Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR., PMID:39820362
Discovery of Glucose Metabolism-Associated Genes in Neuropathic Pain: Insights from Bioinformatics., PMID:39769264
Cellular and Molecular Effects of the Bruck Syndrome-Associated Mutation in the PLOD2 Gene., PMID:39769143
Hypoxia-induced translation of collagen-modifying enzymes PLOD2 and P4HA1 is dependent on RBM4 and eIF4E2 in human colon cancer HCT116 cells., PMID:39710969
Development and characterization of an in vitro fluorescently tagged 3D bone-cartilage interface model., PMID:39600948
Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model., PMID:39566080
PLOD2 exacerbates cervical squamous cell carcinoma by suppressing p53 by binding to YAP1., PMID:39513600
Clinical, genomic, and proteomic perspectives in the analysis of comorbid conditions in type 2 diabetes mellitus: a retrospective study., PMID:39508856
Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1-/- mice., PMID:39256768
Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer., PMID:39184453
DNA methylation of bone morphogenetic protein 7 in leukocytes as a possible biomarker for hand osteoarthritis: A pilot study., PMID:39182186
Generation of bone-specific lysyl hydroxylase 2 knockout mice and their phenotypes., PMID:39156722
Gene-based association analysis of a large patient cohort provides insights into genetics of atypical femur fractures., PMID:39126371
Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction., PMID:39098433
Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta., PMID:39088537
Systematic characterization of the expression, prognosis and immune characteristics of PLOD family genes in breast cancer., PMID:39068670
Effectiveness of whole exome sequencing analyses in the molecular diagnosis of osteogenesis imperfecta., PMID:38953412
Dissecting Crucial Gene Markers Involved in HPV-Associated Oropharyngeal Squamous Cell Carcinoma from RNA-Sequencing Data through Explainable Artificial Intelligence., PMID:38940026
DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding., PMID:38760576
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis., PMID:38696846
A novel prognostic signature based on cancer stemness and metabolism-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma., PMID:38656879
Exome sequencing identified mutations in the WNT1 and COL1A2 genes in osteogenesis imperfecta cases., PMID:38536562
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair., PMID:38472175
Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement., PMID:38462571
Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis., PMID:38335278
METTL3 facilitates renal cell carcinoma progression by PLOD2 m6A-methylation under prolonged hypoxia., PMID:38233403
Spindle cell rhabdomyosarcomas: With TFCP2 rearrangements, and novel EWSR1::ZBTB41 and PLOD2::RBM6 gene fusions. A study of five cases and review of the literature., PMID:38114270
Development and validation of a combined hypoxia- and metabolism-related prognostic signature to predict clinical prognosis and immunotherapy responses in clear cell renal cell carcinoma., PMID:38023248
Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation., PMID:38008826
Identification of Potential Genes and Critical Pathways in Postoperative Recurrence of Crohn's Disease by Machine Learning And WGCNA Network Analysis., PMID:37994325
Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells., PMID:37981258
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts., PMID:37913834
N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele., PMID:37670228
Minoxidil weakens newly synthesized collagen in fibrotic synoviocytes from osteoarthritis patients., PMID:37605092
Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4., PMID:37481725
tDCS Regulates ASBT-3-OxoLCA-PLOD2-PTEN Signaling Pathway to Confer Neuroprotection Following Rat Cerebral Ischemia-Reperfusion Injury., PMID:37477767
Influence of the concentrate inclusion level in a grass silage-based diet on hepatic transcriptomic profiles in Holstein-Friesian dairy cows in early lactation., PMID:37474362
Prognostic model based on telomere-related genes predicts the risk of oral squamous cell carcinoma., PMID:37452322
Integrative transcriptome and proteome analyses of clear cell renal cell carcinoma develop a prognostic classifier associated with thrombus., PMID:37328520
Validation of Fourier Transform Infrared Microspectroscopy for the Evaluation of Enzymatic Cross-Linking of Bone Collagen., PMID:37278762
Exploration and validation of the hub genes involved in hypoxia-induced endothelial-mesenchymal transition of systemic sclerosis., PMID:37246768
PLOD2 promotes colorectal cancer progression by stabilizing USP15 to activate the AKT/mTOR signaling pathway., PMID:37227305
The PLOD2/succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness., PMID:37155842
For research use only. Not for human or drug use.
