Catalog No.
YHK37301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser636-Arg798
Predicted molecular weight
22.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBK2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LEM6, PGC1A, PPARGC1, Ligand effect modulator 6, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC1
Hypoglycemic episodes exacerbate skeletal muscle insulin resistance in type 2 diabetes mellitus., PMID:40510897
A natural thiophene from Eclipta prostrata (L.) combats obesity by enhancing adipocytes thermogenesis in high-fat diet-fed obese mice., PMID:40505954
Sustained oxygen-releasing hydrogel implants enhance flap regeneration by promoting mitochondrial biogenesis under mild hypoxia., PMID:40503164
Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific regulatory mechanisms., PMID:40487563
PGC-1α Promotes NSCLC Progression via FOXM1 Interaction and MUC1 Upregulation., PMID:40481667
MiR-1293 modulates PPARGC1A to promote proliferation and metastasis of oral carcinoma cells., PMID:40471458
Analyzing the potential targets and mechanism of per- and polyfluoroalkyl substances (PFAS) on breast cancer by integrating network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation., PMID:40465018
[Jianpi Qinghua Formula improves metabolic-associated fatty liver disease by modulating PGC1α/PPARα/CPT1A pathway]., PMID:40461206
The impact of exercise on mitochondrial biogenesis in skeletal muscle: A systematic review and meta-analysis of randomized trials., PMID:40459444
Depot-Specific Changes in Gene Expression in the Inguinal and Epididymal Adipose Tissues in Response to the High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mice., PMID:40451204
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson's Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway., PMID:40445460
Weissella confusa Attenuates Cognitive Deficits in Alzheimer's Disease by Reducing Oxidative Stress Via the SIRT1/PGC-1α Signaling Pathway., PMID:40445426
Circulating mitochondrial biomarkers in acute coronary syndrome., PMID:40443515
Melatonin Improves Lipid Homeostasis, Mitochondrial Biogenesis, and Antioxidant Defenses in the Liver of Prediabetic Rats., PMID:40429795
Long-Term Functional and Structural Renoprotection After Experimental Acute Kidney Injury in Subclinical Chronic Kidney Disease In Vivo., PMID:40429761
Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases., PMID:40427436
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function., PMID:40425078
Exercise improves glucose and lipid metabolism in high fat diet feeding male mice through androgen/androgen receptor-mediated metabolism regulatory factors., PMID:40419170
[Curcumin inhibits lipid metabolism in non-small cell lung cancer by downregulating the HIF-1α pathway]., PMID:40415436
[Shenqi Buzhong Formula ameliorates mitochondrial dysfunction in a rat model of chronic obstructive pulmonary disease by activating the AMPK/SIRT1/PGC-1α pathway]., PMID:40415428
Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesis., PMID:40410194
Nanoparticle-mediated targeting of PGC-1α reveals critical metabolic pathways in bladder cancer metastasis., PMID:40404885
SIRT1 and its SUMOylation attenuate hyperoxia-induced lung injury by improving mitochondrial biogenesis and fusion., PMID:40403939
Regulating peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α): A potential role in neurological disorder and treatment., PMID:40403826
[Electroacupuncture activates PKA / CREB signaling pathway to promote browning of white fat in obese rats]., PMID:40390613
Inhibitory effects of high extracellular L-glutamate concentrations on skeletal myogenesis., PMID:40389489
SIRT3 is required for the protective function of ketogenic diet on neural inflammation and neuropathic pain., PMID:40384870
A combinatorial siRNA and mRNA approach for obesity treatment using targeting lipid nanoparticles., PMID:40383157
A cross-sectional study on gut microbiota and inflammation in patients with chronic kidney disease., PMID:40381952
High-dose vitamin C promotes mitochondrial biogenesis in HCT116 colorectal cancer cells by regulating the AMPK/PGC-1α signaling pathway., PMID:40372538
NSD1 mutation status determines metabolic inhibitor sensitivity in head and neck squamous cell carcinomas by regulating mitochondrial respiration., PMID:40371884
Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A2A receptor., PMID:40369420
Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson's disease mice via the GLP-1/PGC-1α pathway., PMID:40368220
Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting., PMID:40368160
Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load., PMID:40366239
Myriocin Restores Metabolic Homeostasis in dAGE-Exposed Mice via AMPK-PGC1α-Mediated Mitochondrial Activation and Systemic Lipid/Glucose Regulation., PMID:40362857
Role of T3 in the Regulation of GRP78 on Granulosa Cells in Rat Ovaries., PMID:40362432
Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress., PMID:40360527
Reprogramming of Hypoxia-Induced Metabolic Disorder in Mouse Kidneys by Mesenchymal Stem Cells Through Improving Mitochondrial Dynamics and Function., PMID:40358967
Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction., PMID:40358602
Chronic stress elicits sex-specific mitochondrial respiratory functional changes in the rat heart., PMID:40356314
Estrogen-related receptors regulate innate and adaptive muscle mitochondrial energetics through cooperative and distinct actions., PMID:40354528
Protective effect of empagliflozin against paracetamol-induced acute kidney injury through modulation of AMPK/SIRT1/PGC-1α pathway in experimental mice., PMID:40349789
Heat shock protein B1-mediated ferroptosis regulates mitochondrial dysfunction in adipose tissue of ketotic dairy cows., PMID:40348370
Icariin attenuates oxidative stress via SIRT1/PGC-1α pathway in SAH mice., PMID:40345568
Exosomes generated from bone marrow mesenchymal stem cells limit the damage caused by myocardial ischemia-reperfusion via controlling the AMPK/PGC-1α signaling pathway., PMID:40334754
From Skeletal Muscle to Myocardium: Molecular Mechanisms of Exercise-Induced Irisin Regulation of Cardiac Fibrosis., PMID:40332022
Metformin restores mitochondrial bioenergetics and redox homeostasis through modulation of mitochondrial biogenesis and dynamics in patient derived cultured fibroblasts and an animal model of molybdenum cofactor deficiency., PMID:40327990
[The regulatory effect and mechanism of PGC-1α on mitochondrial function]., PMID:40326073
Inhibiting mitochondrial excessive fission alleviates the neuronal damage in Parkinson's disease via regulating PGC-1α mediated mitochondrial biogenesis., PMID:40320116
For research use only. Not for human or drug use.
