Catalog No.
YHK37101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu130-Pro180
Predicted molecular weight
34.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BXH1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p53 up-regulated modulator of apoptosis, BBC3, JFY-1, PUMA, Bcl-2-binding component 3, isoforms 1/2
RNA splicing modulator for Huntington's disease treatment induces peripheral neuropathy., PMID:40343270
MLN0905, a new inhibitor of Polo-like kinase 1 (PLK1), enhances the efficiency of lenalidomide in promoting the apoptosis of multiple myeloma cell lines., PMID:40278989
Transcriptomic profiling of autophagy and apoptosis pathways in liver cancer cells treated with a new tyrosine kinase inhibitor PD161570., PMID:40242947
Endoplasmic Reticulum-Dependent Apoptotic Response to Cellular Stress in Patients with Rheumatoid Arthritis., PMID:40141133
The Roles of Forkhead Box O3a (FOXO3a) in Bone and Cartilage Diseases - A Narrative Review., PMID:40034405
PCR array analysis reveals a novel expression profile of ferroptosis-related genes in idiopathic pulmonary fibrosis., PMID:40022042
Anti-Cancer Bioactive Peptide Induces Apoptosis in Gastric Cancer Cells through TP53 Signaling Cascade., PMID:39950267
PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma., PMID:39934141
Mcl-1 is a Gatekeeper Molecule to Regulate the Crosstalk Between Ferroptotic Agent-Induced ER Stress and TRAIL-Induced Apoptosis., PMID:39853862
Identification of the whole genome of alternative splicing and RNA-binding proteins involved in nintedanib-induced apoptosis in gastric cancer cells., PMID:39726754
[Effect of simplified formula of Jinfukang Oral Liquid on apoptosis of renal tubular epithelial cells induced by cisplatin]., PMID:39701770
Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability., PMID:39667498
Antisense-mediated splicing correction as a therapeutic approach for p53 K120R mutation., PMID:39384177
Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors., PMID:39375715
PBLD promotes IRF3 mediated the type I interferon (IFN-I) response and apoptosis to inhibit viral replication., PMID:39362857
Identification of BBC3 as a novel indicator for predicting prostate cancer development and olaparib resistance., PMID:39331229
Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease., PMID:39305937
Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics., PMID:39288289
Mir221- and Mir222-enriched adsc-exosomes mitigate PM exposure-exacerbated cardiac ischemia-reperfusion injury through the modulation of the BNIP3-MAP1LC3B-BBC3/PUMA pathway., PMID:39245438
Mouse models to investigate in situ cell fate decisions induced by p53., PMID:39160273
Epigallocatechin gallate induces apoptosis in multiple myeloma cells through endoplasmic reticulum stress induction and cytoskeletal disruption., PMID:39159563
Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis., PMID:38853192
The novel lnc-HZ12 suppresses autophagy degradation of BBC3 by preventing its interactions with HSPA8 to induce trophoblast cell apoptosis., PMID:38836496
Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis)., PMID:38811536
Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy., PMID:38806674
Dermaseptin B2 bioactive gene's potential for anticancer and anti-proliferative effect is linked to the regulation of the BAX/BBC3/AKT pathway., PMID:38767753
Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication., PMID:38752369
HOPS/TMUB1 Enhances Apoptosis in TP53 Mutation-Independent Setting in Human Cancers., PMID:38731819
In-silico Codon Context and Synonymous Usage Analysis of Genes for Molecular Mechanisms Inducing Autophagy and Apoptosis with Reference to Neurodegenerative Disorders., PMID:38728191
Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression., PMID:38661126
Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis., PMID:38225213
MTFP1 is a mitophagy receptor that operates in PINK1/PRKN-dependent mitophagy and promotes oral cancer cell survival., PMID:40395309
Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia., PMID:37838759
Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma., PMID:37818060
Overexpression of hsa_circ_0001861 inhibits pulmonary fibrosis through targeting miR-296-5p/BCL-2 binding component 3 axis., PMID:37781863
Disruption of caspase-independent cell proliferation pathway on spheroids (HeLa cells) treated with curcumin., PMID:37671809
Effects of miR-143 regulation on cardiomyocytes apoptosis in doxorubicin cardiotoxicity based on integrated bioinformatics analysis., PMID:37597758
Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate., PMID:37549410
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles., PMID:37469132
The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo., PMID:37335333
AHR-mediated m6A RNA methylation contributes to PM2.5-induced cardiac malformations in zebrafish larvae., PMID:37270964
Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cells., PMID:37097390
[Effects of PUMA knockout on the apoptosis of H9C2 cardiomyocytes induced by high glucose]., PMID:37088760
Copper metabolism in cell death and autophagy., PMID:37055935
Total alkaloids in Stephania tetrandra induce apoptosis by regulating BBC3 in human non-small cell lung cancer cells., PMID:37044023
Subtype-selective induction of apoptosis in translocation-related sarcoma cells induced by PUMA and BIM upon treatment with pan-PI3K inhibitors., PMID:36849535
RASSF1 is identified by transcriptome coordination analysis as a target of ATF4., PMID:36723232
The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration., PMID:36688959
Combined BCL-2 and PI3K/AKT Pathway Inhibition in KMT2A-Rearranged Acute B-Lymphoblastic Leukemia Cells., PMID:36674872
Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression., PMID:36431966
For research use only. Not for human or drug use.
