Catalog No.
DHD84012
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
IL-12 subunit p40, IL12B, Interleukin-12 subunit beta, IL-12B, CLMF p40, NKSF2, NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29460
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
HAIL-12, HAIL 12, HAIL12
Clone ID
HAIL-12
Humoral and cellular immune responses in cattle upon Clostridium chauvoei vaccination and challenge., PMID:40463373
The immune checkpoint regulator CD40 potentiates myocardial inflammation., PMID:40217124
High-affinity nanobodies targeting IL-12B for the detection of fluorescence resonance energy transfer., PMID:39921134
Molecular Events in Immune Responses to Sublingual Influenza Vaccine with Hemagglutinin Antigen and Poly(I:C) Adjuvant in Nonhuman Primates, Cynomolgus Macaques., PMID:38932372
IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not γδT 17 cells, in TAC mice., PMID:38677538
Targeting pathogenic CD8+ tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitis., PMID:38580644
CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2 + macrophages and CD8 T-cells., PMID:38559055
Dupilumab-associated ocular surface disease is characterized by a shift from Th2/Th17 toward Th1/Th17 inflammation., PMID:38317432
The Immune Signature of CSF in Multiple Sclerosis with and without Oligoclonal Bands: A Machine Learning Approach to Proximity Extension Assay Analysis., PMID:38203309
Serological Conversion through a Second Exposure to Inactivated Foot-and-Mouth Disease Virus Expressing the JC Epitope on the Viral Surface., PMID:37766163
Multi-phasic gene profiling using candidate gene approach predict the capacity of specific antibody production and maintenance following COVID-19 vaccination in Japanese population., PMID:37564647
Paraneoplastic or not? Sirtuin 2 in anti-N-methyl-d-aspartate receptor encephalitis., PMID:37483157
Condyloma acuminata: An evaluation of the immune response at cellular and molecular levels., PMID:37053156
IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL/6 mice infected with Theiler's murine encephalomyelitis virus., PMID:36872323
Mycobacterium avium subsp. paratuberculosis antigens induce cellular immune responses in cattle without causing reactivity to tuberculin in the tuberculosis skin test., PMID:36741398
Analysis of gene expression profiles to study malaria vaccine dose efficacy and immune response modulation., PMID:36239109
Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients., PMID:36118416
The Inflammatory Factor SNP May Serve as a Promising Biomarker for Acitretin to Alleviate Secondary Failure of Response to TNF-a Monoclonal Antibodies in Psoriasis., PMID:35814239
Biomarkers of systemic treatment response in people with psoriasis: a scoping review., PMID:35606928
CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model., PMID:35538512
Biomarkers of disease progression in people with psoriasis: a scoping review., PMID:35482474
Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature., PMID:34389021
STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses., PMID:33446493
The Improvement of Immune Effect of Recombinant Human Beta-Defensin 2 on Hepatitis B Vaccine in Mice., PMID:33370550
IL-23 skin and joint profiling in psoriatic arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors., PMID:33243781
Lung CD103+dendritic cells and Clec9a signaling are required for neonatal hyperoxia-induced inflammatory responses to rhinovirus infection., PMID:33112186
Genetic Basis of Response of Ghanaian Local Chickens to Infection With a Lentogenic Newcastle Disease Virus., PMID:32849779
Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers., PMID:32849633
Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn's Disease., PMID:32679193
Anti-IL-12/23 p40 antibody attenuates chronic graft-versus-host disease with lupus nephritis via inhibiting Tfh cell in mice., PMID:32580046
Specific single nucleotide polymorphism genotypes and association of an IL-12B polymorphism with secondary failure of infliximab therapy in Japanese psoriasis patients., PMID:32576423
Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface., PMID:32574621
Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives., PMID:32567373
Impact of fascioliasis reinfection on Fasciola hepatica egg shedding: relationship with the immune-regulatory response., PMID:32371223
Effect of adalimumab on the expression profile of mRNA, and protein associated with JAK/STAT signaling pathway in fibroblast exposed to lipopolysaccharide., PMID:32276291
High interleukin-18 and low FOXP3 mRNAs in peripheral blood of women with severe systemic lupus erythematosus: a cross-sectional study., PMID:32152765
Short-term transcriptional response to IL-17 receptor-A antagonism in the treatment of psoriasis., PMID:31883845
Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin-1β., PMID:31478196
IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans., PMID:31470035
Host Genetics of Cytomegalovirus Pathogenesis., PMID:31396258
Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients., PMID:31377797
In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine., PMID:31131048
Irf5 deficiency in myeloid cells prevents necrotizing enterocolitis by inhibiting M1 macrophage polarization., PMID:31086271
Establishment and Expression of Cytokines in a Theileria annulata-Infected Bovine B Cell Line., PMID:31052316
A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post-myocardial infarction., PMID:30949687
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions., PMID:30774023
The analysis of the therapeutic potential of ustekinumab in psoriasis vulgaris treatment., PMID:30693647
Severe disseminated Nocardia infection associated with ustekinumab treatment for psoriasis., PMID:30657168
Oral Administration of Human Polyvalent IgG by Mouthwash as an Adjunctive Treatment of Chronic Oral Candidiasis., PMID:30627128
Case of pityriasis rubra pilaris progressed to generalized erythroderma following blockade of interleukin-17A, but improved after blockade of interleukin-12/23 p40., PMID:30506728
For research use only. Not for human or drug use.
