Catalog No.
DHD84006
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
IL-12 subunit p40, IL12B, Interleukin-12 subunit beta, IL-12B, CLMF p40, NKSF2, NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29460
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
ART123
Clone ID
ART123
Coagulofibrinolytic effects of recombinant soluble thrombomodulin in prolonged porcine cardiac arrest., PMID:37811363
An Experience of Multiple Hematomas in a Coronavirus Disease-19 Patient Administered with ART-123 and Heparin., PMID:34079393
Effects of Thrombomodulin in Reducing Lethality and Suppressing Neutrophil Extracellular Trap Formation in the Lungs and Liver in a Lipopolysaccharide-Induced Murine Septic Shock Model., PMID:34066510
Efficacy and safety of human soluble thrombomodulin (ART-123) for treatment of patients in France with sepsis-associated coagulopathy: post hoc analysis of SCARLET., PMID:33788052
Correction to: A placebo‑controlled, double‑blind, randomized study of recombinant thrombomodulin (ART‑123) to prevent oxaliplatin‑induced peripheral neuropathy., PMID:33136172
A placebo-controlled, double-blind, randomized study of recombinant thrombomodulin (ART-123) to prevent oxaliplatin-induced peripheral neuropathy., PMID:32965539
Beneficial effect modification on survival outcome of sepsis between ART-123 and polymyxin B‑immobilised haemoperfusion: a nationwide Japanese registry study., PMID:32405776
Efficacy and safety of recombinant human soluble thrombomodulin in patients with sepsis-associated coagulopathy: A systematic review and meta-analysis., PMID:32237269
Human Soluble Recombinant Thrombomodulin, ART-123, Resolved Early Phase Coagulopathies, but Did Not Significantly Alter the 28 Day Outcome in the Treatment of DIC Associated with Infectious Systemic Inflammatory Response Syndromes., PMID:31569648
Individualized recombinant human thrombomodulin (ART-123) administration in sepsis patients based on predicted phenotypes., PMID:31234901
Plasma From Patients Undergoing Liver Transplantation Is Resistant to Anticoagulant Activity of Soluble Thrombomodulin., PMID:30067306
Pharmacokinetics of recombinant human soluble thrombomodulin in disseminated intravascular coagulation patients with acute renal dysfunction., PMID:28229162
Anti-inflammatory and anti-fibrinolytic effects of thrombomodulin alfa through carboxypeptidase B2 in the presence of thrombin., PMID:27693845
Soluble Thrombomodulin Ameliorates Ischemia-Reperfusion Injury of Liver Grafts by Modulating the Proinflammatory Role of High-Mobility Group Box 1., PMID:27523810
Population pharmacokinetic analysis of thrombomodulin alfa to support dosing rationale in patients with renal impairment., PMID:27140801
Dysregulation of inflammatory and hemostatic markers in sepsis and suspected disseminated intravascular coagulation., PMID:24254894
Recombinant soluble thrombomodulin as an adjunctive treatment for sepsis and disseminated intravascular coagulation: relatively safe and possibly effective., PMID:23979366
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation., PMID:23979365
Thrombin generation mediators and markers in sepsis-associated coagulopathy and their modulation by recombinant thrombomodulin., PMID:23804232
Neuroleptic malignant syndrome-induced massive coagulopathy treated by recombinant human soluble thrombomodulin., PMID:23218866
Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors., PMID:22410019
Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation., PMID:21781252
Improvement of blood compatibility on polysulfone-polyvinylpyrrolidone blend films as a model membrane of dialyzer by physical adsorption of recombinant soluble human thrombomodulin (ART-123)., PMID:21310110
New parenteral anticoagulants in development., PMID:21045018
Enhancement of the blood compatibility of dialyzer membranes by the physical adsorption of human thrombomodulin (ART-123)., PMID:20845484
Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia., PMID:19487933
Physical adsorption of human thrombomodulin (ART-123) onto polymeric biomaterials for developing an antithrombogenic blood-contacting material., PMID:17584906
New anticoagulants for the prevention and treatment of venous thromboembolism., PMID:17319097
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial., PMID:17059423
Prophylaxis against venous thromboembolism in orthopedic surgery., PMID:16849000
Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement., PMID:15869592
Phase I study of a novel recombinant human soluble thrombomodulin, ART-123., PMID:15456485
[Anticoagulant]., PMID:15197947
New anticoagulants for venous thromboembolic disease., PMID:14730467
Novel anticoagulants for the prevention and treatment of venous thromboembolism., PMID:14648923
ART-123 Asahi Kasei., PMID:12211414
A novel recombinant soluble human thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers., PMID:9650544
Pharmacokinetics and safety of a novel recombinant soluble human thrombomodulin, ART-123, in healthy male volunteers., PMID:9597558
For research use only. Not for human or drug use.
