Catalog No.
DHK27802
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9Y5U5
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
AMG-228, AMG 228, AMG228
Clone ID
AMG 228
OX40/OX40 ligand and its role in precision immune oncology., PMID:38526805
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality., PMID:31324216
GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma., PMID:30719701
Harnessing co-stimulatory TNF receptors for cancer immunotherapy: Current approaches and future opportunities., PMID:28085016
Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted., PMID:26423152
OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy., PMID:24732076
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies., PMID:23897982
Agonist antibodies to TNFR molecules that costimulate T and NK cells., PMID:23460535
Analysis of HLDA9 mAbs on plasmacytoid dendritic cells., PMID:20933012
New B-cell CD molecules., PMID:20933010
Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation., PMID:20923684
For research use only. Not for human or drug use.
