Catalog No.
PHC08001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD74 (Leu78-Lys208).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
HLA-DR antigens-associated invariant chain,HLA class II histocompatibility antigen gamma chain,CD74,CLIP,Ia antigen-associated invariant chain,DHLAG,Ii
Purification
Purified by antigen affinity column.
Accession
P04233
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
CX3CR1+ Monocytes/Macrophages Promote Regional Immune Injury in Mesangial Proliferative Glomerulonephritis through Crosstalk with Activated Mesangial Cells., PMID:40458609
MIF regulates T helper 17 cell differentiation by activating the p38 MAPK signaling pathway to drive the pathogenesis of EAP., PMID:40440956
Lysine-specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti-programmed death 1 therapy in liver cancer., PMID:40356247
Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia., PMID:40352549
Exploring the role of the CD74+ cardiac macrophage subset in trastuzumab cardiotoxicity and its mechanisms., PMID:40316056
Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer., PMID:40260248
Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation., PMID:40226614
Combination therapy with Chicoric acid and PD-1/PD-L1 blockade improves the immunotherapy response in patient-derived ovarian cancer xenograft model., PMID:40087780
Anti-CD74 autoantibodies in axial spondyloarthritis as biomarkers for activity and severity of disease but not for tumour necrosis factor inhibitor retention: data from the Swiss Clinical Quality Management in rheumatic diseases cohort., PMID:40063233
Preclinical in vitro and in vivo evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas., PMID:40036608
System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans., PMID:39747435
Benzo (A) pyrene exposure alters alveolar epithelial and macrophage cells diversity and induces antioxidant responses in lungs., PMID:39506978
The VEGF-Mediated Cytoprotective Ability of MIF-Licensed Mesenchymal Stromal Cells in House Dust Mite-Induced Epithelial Damage., PMID:39502000
Potential protumor function of CD74 in clear cell renal cell carcinoma., PMID:39080216
Antibiotic use attenuates response to immune checkpoint blockade in urothelial carcinoma via inhibiting CD74-MIF/COPA: revealing cross-talk between anti-bacterial immunity and ant-itumor immunity., PMID:38995167
Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies., PMID:38972295
Reconstituted CD74+ NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation., PMID:38936148
The role of macrophage migration inhibitory factor family and CD74 in the pathogenesis of melanoma., PMID:38884501
Infliximab modifies CD74-mediated lymphatic abnormalities and adipose tissue alterations in creeping fat of Crohn's disease., PMID:38713235
MIF-Modulated Spinal Proteins Associated with Persistent Bladder Pain: A Proteomics Study., PMID:38674069
[Not Available]., PMID:38585235
Expert Consensus on the Diagnosis and Treatment of NRG1/2 Gene Fusion Solid Tumors., PMID:38414979
Granzyme B+ B cells detected by single-cell sequencing are associated with prognosis in patients with intrahepatic cholangiocarcinoma following liver transplantation., PMID:38386050
Year in Review in Axial Spondyloarthritis Clinical Research and Guidelines: SPARTAN 2023 Annual Meeting Proceedings., PMID:38340269
CD74 is associated with inflamed tumor immune microenvironment and predicts responsiveness to PD-1/CTLA-4 bispecific antibody in patients with solid tumors., PMID:38280003
Serum biomarkers and their relationship to axial spondyloarthritis associated with inflammatory bowel diseases., PMID:38168574
Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity., PMID:37935315
Uncovering therapeutic opportunities in the clinical development of antibody-drug conjugates., PMID:37740463
A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models., PMID:37740214
Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status., PMID:37642473
Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain., PMID:37118836
Migration inhibitory factor and cluster of differentiation 74-mediated dendritic cell apoptosis exacerbates acute acetaminophen-induced liver injury., PMID:37102665
Predictive value of CXCL10 for the occurrence of immune-related adverse events in patient with renal cell carcinoma., PMID:36975091
Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype., PMID:36931600
Single-cell atlas of the immune microenvironment reveals macrophage reprogramming and the potential dual macrophage-targeted strategy in multiple myeloma., PMID:36852636
Diagnostic value of the anti-CD74 antibodies for axial spondyloarthritis: Results of a prospective study in patients with suspicious low back pain., PMID:36706946
Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001., PMID:36634212
OMIP-088: Twenty-target imaging mass cytometry panel for major cell populations in mouse formalin fixed paraffin embedded liver., PMID:36602064
Preclinical studies targeting CD74 with STRO-001 antibody-drug conjugate in acute leukemia., PMID:36595452
Exploring the potential molecular mechanism of trastuzumab-induced cardiotoxicity based on RNA sequencing and bioinformatics analysis., PMID:36563885
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals., PMID:36532041
PD-L1 is required for estrogen-induced protection against severe EAE in IL-10 deficient mice1., PMID:36454506
Development of combinatorial antibody therapies for diffuse large B cell lymphoma., PMID:36353222
The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead., PMID:36334452
Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma (MM)., PMID:36315425
Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning., PMID:36211422
Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses., PMID:36070690
Macrophage migration inhibitory factor (MIF) and IgA anti CD74 antibodies in Indian patients with enthesitis-related arthritis category of Juvenile idiopathic arthritis., PMID:35907018
Single-cell RNA Sequencing Analysis Reveals New Immune Disorder Complexities in Hypersplenism., PMID:35865544
Altered Circulating Immune Cell Distribution in Traumatic Spinal Cord Injury Patients in Relation to Clinical Parameters., PMID:35837411
For research use only. Not for human or drug use.
