Catalog No.
DHF84503
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
MDM2, Hdm2, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3 ubiquitin transferase Mdm2, Double minute 2 protein, Oncoprotein Mdm2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q00987
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
OM-301, OM 301, OM301
Clone ID
OM-301
The Intrabody Against Murine Double Minute 2 via a p53-Dependent Pathway Induces Apoptosis of Cancer Cell., PMID:40508092
3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells., PMID:40381037
Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era., PMID:40361510
Combined Chemotherapy-Immunotherapy for Advanced Biliary Tract Cancer (BTC): A Clinical, Genomic, and Biomarker Analysis., PMID:40167580
O-Cyanobenzaldehydes Irreversibly Modify Both Buried and Exposed Lysine Residues in Live Cells., PMID:40150802
Fc fragment of IgG binding protein suppresses tumor growth by stabilizing wild type P53 in colorectal cancer cells., PMID:40108539
Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research., PMID:39804528
Tumor-derived CCL15 regulates RNA m6A methylation in cancer-associated fibroblasts to promote hepatocellular carcinoma growth., PMID:39734010
MDM2 drives resistance to Osimertinib by contextually disrupting FBW7-mediated destruction of MCL-1 protein in EGFR mutant NSCLC., PMID:39543744
NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes., PMID:39472976
IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility., PMID:39368400
A metabolic crosstalk between liposarcoma and muscle sustains tumor growth., PMID:39266552
SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11-MDM2-p53 Pathway in Glioma., PMID:39258423
Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells., PMID:38967656
Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses., PMID:38941598
Revised Diagnosis From Histiocytic Neoplasm to Optic Chiasm Glioblastoma After Genetic Analysis., PMID:38926909
Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption., PMID:38802154
TP53 Mutations in Acute Leukemias and Myelodysplastic Syndromes: Insights and Treatment Updates., PMID:38768424
HER3 (ERBB3) amplification in liposarcoma - a putative new therapeutic target?, PMID:38760830
Anticancer therapeutic strategies for targeting mutant p53-Y220C., PMID:38738269
Management of High-Risk Neuroblastoma with Soft-Tissue-Only Disease in the Era of Anti-GD2 Immunotherapy., PMID:38730688
Glioblastoma Therapy: Past, Present and Future., PMID:38473776
Comparative Expression Analysis of TP53 Tumor Suppressor and MDM2 Oncogene in Colorectal Adenocarcinoma., PMID:38434910
Alternative polyadenylation determines the functional landscape of inverted Alu repeats., PMID:38309276
Targeted inhibition of the ATR/CHK1 pathway overcomes resistance to olaparib and dysregulates DNA damage response protein expression in BRCA2MUT ovarian cancer cells., PMID:38114660
Immunoexpression of HER2 pathway related markers in HER2 invasive breast carcinomas treated with trastuzumab., PMID:37977031
Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins., PMID:37906525
A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review., PMID:37735390
DNA-dependent protein kinase catalytic subunit binds to the transactivation domain 1 of NF-κB p65., PMID:37674974
Impact of Amplified Oncogenes on Salivary Gland Carcinomas., PMID:37671310
Emerging roles of Aurora-A kinase in cancer therapy resistance., PMID:37521867
SF3B1 Mutations Are Associated with Resistance to Non-Genotoxic MDM2 Inhibition in Chronic Lymphocytic Leukemia., PMID:37511096
Building on Foundations: Venetoclax-Based Combinations in the Treatment of Acute Myeloid Leukemia., PMID:37509251
GADD34 activates p53 and may have utility as a marker of atherosclerosis., PMID:37228401
Histological and biochemical evaluation of the effects of silver nanoparticles (AgNps) versus titanium dioxide nanoparticles (TiO2NPs) on rat parotid gland., PMID:37132546
Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer., PMID:37091148
Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy., PMID:37024504
Role of p53 in breast cancer progression: An insight into p53 targeted therapy., PMID:36923534
Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy., PMID:36923503
ISG20L1 acts as a co-activator of DAPK1 in the activation of the p53-dependent cell death pathway., PMID:36855954
Comprehensive immunohistochemical analysis based on the origin of leiomyosarcoma., PMID:36734438
Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions., PMID:36697672
IHC expression of AKT in different grades of epithelial dysplasia: An in vitro study., PMID:36588841
Atezolizumab Plus Bevacizumab as First-line Treatment for Patients With Metastatic Nonsquamous Non-Small Cell Lung Cancer With High Tumor Mutation Burden: A Nonrandomized Controlled Trial., PMID:36520426
Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels., PMID:36358737
Oral Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report., PMID:36246198
Effects of chloroquine and hydroxychloroquine on the sensitivity of pancreatic cancer cells to targeted therapies., PMID:36243652
CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis., PMID:36182968
Immunohistochemical Detection and Prognostic Significance of p53, Epidermal Growth Factor Receptor, Murine Double Minute 2, and Isocitrate Dehydrogenase 1 in Glioblastoma Multiforme Patients of Pakistan., PMID:36035640
Multiple Myeloma: Bioinformatic Analysis for Identification of Key Genes and Pathways., PMID:35958298
For research use only. Not for human or drug use.
