Catalog No.
DHC84801
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
IAPP, Islet amyloid polypeptide, Diabetes-associated peptide, Insulinoma amyloid peptide, Amylin, DAP
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P10997
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
NI-203, NI 203, NI203
Clone ID
NI-203
Amyloid Targeting-Gold Nanoparticles-Assisted X-ray Therapy Rescues Islet β-Cells from Amyloid Fibrils and Restores Insulin Homeostasis., PMID:39884779
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein., PMID:39822034
The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats., PMID:39639536
Synergistic-like decreases in alcohol intake following combined pharmacotherapy with GLP-1 and amylin in male rats., PMID:39622492
Screening of Diabetes-Associated Autoantigens and Serum Antibody Profiles Using a Phage Display System., PMID:39483642
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes., PMID:39214091
Okinawa-Based Nordic Diet Decreases Plasma Levels of IAPP and IgA against IAPP Oligomers in Type 2 Diabetes Patients., PMID:39062913
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein., PMID:38603770
Mapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice., PMID:38455055
A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models., PMID:37813862
Identification of Autoantibodies to a Hybrid Insulin Peptide in Type 1 Diabetes., PMID:37685398
Skin capillary amylin deposition resembles brain amylin vasculopathy in rats., PMID:37572602
Future targets for migraine treatment beyond CGRP., PMID:37370051
Is islet amyloid polypeptide indeed expressed in the human brain?, PMID:37317631
Molecular Insights into the Self-Assembly of a Full-Length hIAPP Trimer: β-Protofibril Formed by β-Hairpin Lateral or Longitudinal Association., PMID:37262327
Rapid, scalable assay of amylin-β amyloid co-aggregation in brain tissue and blood., PMID:37030503
Plasma IAPP-Autoantibody Levels in Alzheimer's Disease Patients Are Affected by APOE4 Status., PMID:36835187
Studies on alpha-synuclein and islet amyloid polypeptide interaction., PMID:36793785
Human Islet Amyloid Polypeptide (hIAPP) Protofibril-Specific Antibodies for Detection and Treatment of Type 2 Diabetes., PMID:36257905
A Novel Tolerogenic Antibody Targeting Disulfide-Modified Autoantigen Effectively Prevents Type 1 Diabetes in NOD Mice., PMID:36032077
Characterization of erenumab and rimegepant on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 receptor., PMID:35614383
Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists., PMID:35436670
Calcitonin receptor antibody validation and expression in the rodent brain., PMID:35410497
[The efficacy of eculizumab against post-thymectomy exacerbations in thymoma associated myasthenia gravis (MG)]., PMID:35354724
Conformation-reconstructed multivalent antibody mimic for amplified mitigation of human islet amyloid polypeptide amyloidogenesis., PMID:35133388
Anti-IAPP Monoclonal Antibody Improves Clinical Symptoms in a Mouse Model of Type 2 Diabetes., PMID:34835247
Targeted RNA Sequencing of VZV-Infected Brain Vascular Adventitial Fibroblasts Indicates That Amyloid May Be Involved in VZV Vasculopathy., PMID:34759019
Identification of transmissible proteotoxic oligomer-like fibrils that expand conformational diversity of amyloid assemblies., PMID:34354242
Migraine therapeutics differentially modulate the CGRP pathway., PMID:33626922
Amylin antibodies frequently display cross-reactivity with CGRP: characterization of eight amylin antibodies., PMID:33565362
Protein-conformational diseases in childhood: Naturally-occurring hIAPP amyloid-oligomers and early β-cell damage in obesity and diabetes., PMID:32833960
Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells., PMID:32809013
Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro., PMID:32728889
A Different hIAPP Polymorph Is Observed in Human Serum Than in Aqueous Buffer: Demonstration of a New Method for Studying Amyloid Fibril Structure Using Infrared Spectroscopy., PMID:32706257
Computational prediction of protein aggregation: Advances in proteomics, conformation-specific algorithms and biotechnological applications., PMID:32637039
Influence of human amylin on the membrane stability of rat primary hippocampal neurons., PMID:32463790
Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus., PMID:32131431
Human Plasma Protein Corona of Aβ Amyloid and Its Impact on Islet Amyloid Polypeptide Cross-Seeding., PMID:31909987
Slowly Progressive Type 1 Diabetes Mellitus: Current Knowledge And Future Perspectives., PMID:31819572
Unpacking the aggregation-oligomerization-fibrillization process of naturally-occurring hIAPP amyloid oligomers isolated directly from sera of children with obesity or diabetes mellitus., PMID:31804529
Monolayer Sensitivity Enables a 2D IR Spectroscopic Immuno-biosensor for Studying Protein Structures: Application to Amyloid Polymorphs., PMID:31246039
Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen., PMID:30663210
Ultraeffective Inhibition of Amyloid Fibril Assembly by Nanobody-Gold Nanoparticle Conjugates., PMID:30585717
Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells., PMID:30463298
CGRP, Amylin, Immunology, and Headache Medicine., PMID:30390312
Gut Microbiome in BALB/c and C57BL/6J Mice Undergoing Experimental Thyroid Autoimmunity Associate with Differences in Immunological Responses and Thyroid Function., PMID:30107619
Zinc Chelator Inhibits Zinc-Induced Islet Amyloid Polypeptide Deposition and Apoptosis in INS-1 Cells., PMID:30027367
Amperometric immunoassay for the obesity biomarker amylin using a screen printed carbon electrode functionalized with an electropolymerized carboxylated polypyrrole., PMID:29886520
Immunoadsorption plasmapheresis treatment for the recurrent exacerbation of neuromyelitis optica spectrum disorder with a fluctuating anti-aquaporin-4 antibody level., PMID:29675599
Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies., PMID:29536165
For research use only. Not for human or drug use.
