Catalog No.
FHF66410
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Conjugation
Unconjugated
Target
C-type lectin domain family 8 member A, LOX-1, Ox-LDL receptor 1, Lectin-like oxidized LDL receptor 1, OLR1, Oxidized low-density lipoprotein receptor 1, Lectin-like oxLDL receptor 1, LOX1, CLEC8A, hLOX-1, Lectin-type oxidized LDL receptor 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P78380
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0778
Comparative analysis of Lox-1 and CD36 expression in human platelets and on circulating microparticles during ARDS-induced coagulopathy., PMID:39546984
Differential Effects of LOX-1 Inhibition on Aortic Structure and Posterior Cerebral Artery Structure and Function in an Experimental Model of Preeclampsia., PMID:38858329
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15., PMID:37468019
Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model., PMID:36874245
LOX-1 Regulates Neutrophil Apoptosis and Fungal Load in A. Fumigatus Keratitis., PMID:34264144
TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies., PMID:33483748
Role of LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1) as a Cardiovascular Risk Predictor: Mechanistic Insight and Potential Clinical Use., PMID:33176449
Interleukin-1β Promotes Ox-LDL Uptake by Human Glomerular Mesangial Cells via LOX-1., PMID:32410835
Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration., PMID:31945611
Role of oxidative stress-related biomarkers in heart failure: galectin 3, α1-antitrypsin and LOX-1: new therapeutic perspective?, PMID:31782085
LOX-1 is involved in TLR2 induced RANKL regulation in peri-implantitis., PMID:31655342
Wnt5a is involved in LOX-1 and TLR4 induced host inflammatory response in peri-implantitis., PMID:31593304
C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake., PMID:31562393
Oxidized low-density lipoproteins induce tissue factor expression in T-lymphocytes via activation of lectin-like oxidized low-density lipoprotein receptor-1., PMID:31504248
Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor 1 Predicts the Changes of Rheumatoid Factor Titers in Rheumatoid Arthritis., PMID:31397763
[Effect and mechanism of PCSK9 on lectin-like oxidized low-density lipoprotein receptor-1 mediated oxidized low-density lipoprotein uptake by THP-1 derived macrophages]., PMID:31142080
Galectin-3 aggravates ox-LDL-induced endothelial dysfunction through LOX-1 mediated signaling pathway., PMID:30963716
A Novel Cell-Free, Non-Fluorescent Method to Measure LOX-1-Binding Activity Corresponding to The Functional Activity of HDL., PMID:30944265
Protamine may have anti-atherogenic potential by inhibiting the binding of oxidized-low density lipoprotein to LOX-1., PMID:30871430
Albiflorin inhibits the formation of THP-1-derived foam cells through the LOX-1/NF-κB pathway., PMID:30371044
CRP and LOX-1: a Mechanism for Increasing the Tumorigenic Potential of Colorectal Cancer Carcinoma Cell Line., PMID:30368730
Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries., PMID:30352791
Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis., PMID:30343086
NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies., PMID:30327444
Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis., PMID:30172652
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis., PMID:29446213
Osteopontin contributes to effective neutrophil recruitment, IL-1β production and apoptosis in Aspergillus fumigatus keratitis., PMID:29359350
Enhanced Bioactivity of the Anti-LOX-1 scFv Engineered by Multimerization Strategy., PMID:29124655
Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides., PMID:29094051
Electronegative L5-LDL induces the production of G-CSF and GM-CSF in human macrophages through LOX-1 involving NF-κB and ERK2 activation., PMID:29078142
LOX-1 mediated phenotypic switching of pulmonary arterial smooth muscle cells contributes to hypoxic pulmonary hypertension., PMID:29069578
Electronegative Low-Density Lipoprotein L5 Induces Adipose Tissue Inflammation Associated With Metabolic Syndrome., PMID:29029093
LOX-1 is involved in IL-1β production and extracellular matrix breakdown in dental peri-implantitis., PMID:28898769
The role of the lectin-like oxLDL receptor (LOX-1) in traffic-generated air pollution exposure-mediated alteration of the brain microvasculature in Apolipoprotein (Apo) E knockout mice., PMID:28816559
Possible involvement of the oxLDL/LOX-1 system in the pathogenesis and progression of human intervertebral disc degeneration or herniation., PMID:28785062
Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL., PMID:28642826
Association of angiotensin II receptor 1 and lectin-like oxidized low-density lipoprotein receptor-1 mediates the cardiac hypertrophy induced by oxidized low-density lipoprotein., PMID:28595908
LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats., PMID:28259654
Pathological and molecular analyses of atherosclerotic lesions in ApoE-knockout mice., PMID:28247010
Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses., PMID:28202751
L5-LDL from ST-elevation myocardial infarction patients induces IL-1β production via LOX-1 and NLRP3 inflammasome activation in macrophages., PMID:27864235
LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis., PMID:27694040
ox-LDL induces endothelial dysfunction by promoting Arp2/3 complex expression., PMID:27181356
Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques., PMID:27077384
Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells., PMID:27077111
Regulation of Coronary Endothelial Function by Interactions between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice., PMID:27050429
Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells., PMID:27031525
Plasma sLOX-1 is a potent biomarker of clinical remission and disease activity in patients with seropositive RA., PMID:26911839
MiR-590-5p-meidated LOX-1 upregulation promotes Angiotensin II-induced endothelial cell apoptosis., PMID:26906623
The lectin-like oxidized LDL receptor-1: a new potential molecular target in colorectal cancer., PMID:26895376
For research use only. Not for human or drug use.
