Research Grade Anti-Human APC/Activated protein C (TPP-2312/BAY1316786)

Catalog No.

DHC05901

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2

Clonality

Monoclonal

Target

Anticoagulant protein C, Vitamin K-dependent protein C, Blood coagulation factor XIV, Autoprothrombin IIA, PROC

Concentration

1.98 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P04070

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

TPP-2312, BAY1316786

Clone ID

BAY1316786

Enzymatic carbon-fluorine bond cleavage by human gut microbes., PMID:40512801

Pulsatile Myofilament Activity in Myotrem Myopathy Associated with Myogenic Tremor., PMID:40508067

Hsa_circ_0049271 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance by Enhancing Cellular Senescence via miR-455-5p/ETS1., PMID:40503776

ARP2/3 regulates cell surface dynamics of CeTOCA-1 in C. elegans zygotes., PMID:40501091

Thrombophilia Testing in Venous Thromboembolism., PMID:40500088

Structural determinants of PAR1 cleavage by activated protein C., PMID:40499721

Apolipoprotein A-IV regulates coagulation and ischemic stroke by potentiating activated protein C., PMID:40499720

Ethanol alters mechanosensory habituation in C. elegans by way of the BK potassium channel through a novel mechanism., PMID:40498794

Kinesin-2 autoinhibition requires elbow phosphorylation., PMID:40497557

Dynamic Birth and Death of Argonaute Gene Family Functional Repertoire Across Caenorhabditis Nematodes., PMID:40497303

Dissecting the endothelial cell landscape in meningioma: single-cell insights into PLVAP+ subpopulations and their role in tumor angiogenesis., PMID:40496867

Thrombomodulin Arg403Lys mutation impairs protein C activation and increases thrombosis risk., PMID:40494134

Evaluation of pharmacokinetics of intravenous protein C concentrate in protein C deficiency: implications for treatment initiation and maintenance., PMID:40492255

Evaluation of Trauma-Induced Coagulopathy by Systematic Insights Into Pathophysiology and Advances in Emergency Resuscitation., PMID:40491626

Neurovirulence of Zika virus-encoded proteins., PMID:40483309

The slow elimination of 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene in mice leads to prolonged constitutive androstane receptor activation and hepatomegaly., PMID:40482433

Comprehensive Characterisation of the RFC1 Repeat in an Australian Cohort., PMID:40481300

Endothelial Protein C Receptor and Thrombomodulin Facilitate Protease-Activated Receptor 1 Cleavage at Arginine-46 by Thrombin and Activated Protein C., PMID:40480637

[Precision diagnosis and genetic counseling for early-onset hereditary thrombosis]., PMID:40467464

Endothelial Function by Flow-Mediated Dilation (FMD) in the Brachial Artery in Hypertensive Patients., PMID:40465902

Impact of the intronic RFC1 expansion size in CANVAS phenotype: an oculomotor study., PMID:40461673

Highly sensitive CdSe/ZnS quantum dots immunosensor via DNA tetrahedra nanostructure-assembled with multiple hybridization chain reaction., PMID:40460458

Notch controls APC/CFZR-1 to enable accumulation of chromatin regulators in germline stem cells from Caenorhabditis elegans., PMID:40446035

Application of RNA-seq for single nucleotide variation identification in a cohort of patients with hypertrophic cardiomyopathy., PMID:40442228

Genotype versus laboratory phenotype correlation of defects in natural anticoagulants in patients with venous thromboembolism., PMID:40436275

From Circulating Biomarkers to Polymorphic Variants: A Narrative Review of Challenges in Thrombophilia Evaluation., PMID:40429442

Disparate Molecular Properties of Two Hypertrophic Cardiomyopathy-Associated cMyBP-C Mutants Reveal Distinct Pathogenic Mechanisms Beyond Haploinsufficiency., PMID:40426840

H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation., PMID:40426273

Diagnosing protein S deficiency - Navigating challenges., PMID:40419135

Nesfatin-1 Suppresses Inflammation in Bronchopulmonary Dysplasia by Regulating HMGB-1/TLR4/p65/NLRP3 Signaling Pathway., PMID:40415368

Novel p.C252G and p.C280X mutations in EGF-1 domain of thrombomodulin lead to a thrombosis-bleeding syndrome., PMID:40414460

Development and evaluation of a new affiprobe that targets HER 3 positive cells using protein engineering., PMID:40414339

Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity., PMID:40407837

In silico report on five high-risk protein C pathogenic variants: G403R, P405S, S421N, C238S, and I243T., PMID:40403510

Characterization of the Endothelial, Coagulofibrinolytic and Inflammatory Profile in Burn Patients after Resuscitation with Fresh Frozen Plasma., PMID:40402034

Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans., PMID:40399944

USP25-driven KIFC1 regulates MYCBP expression and promotes the progression of cervical cancer., PMID:40379626

Hepatic adenomas in males: Is molecular characterization helpful in guiding its management?, PMID:40379140

Centralspindlin is partially required for C. elegans anchor cell specification, vulval induction and morphogenesis., PMID:40379077

Natural anti-aging innovations: Bakuchiol role in longevity and stress resilience through DAF-16 pathway activation., PMID:40378613

Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain., PMID:40377985

Genome-wide association study-driven identification of thrombomodulin and factor V as the best biomarker combination for deep vein thrombosis., PMID:40375318

E26 transformation-specific-1 controls asthma development by regulating the CD4+ Th2/Th17 immune response involved transcription factors in active genomic transcriptional regions., PMID:40372772

Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis., PMID:40372451

Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach., PMID:40370698

Postpartum maternal thrombophilia workup value in pregnancies with severe small for gestational age., PMID:40369883

Mavacamten Inhibits the Effect of the N-Terminal Fragment of Cardiac Myosin-Binding Protein C with the L352P Mutation on the Actin-Myosin Interaction at Low Calcium Concentrations., PMID:40367081

Hemostatic parameters in transgender women receiving gender-affirming hormone therapy: A shift to a cisgender female pattern?, PMID:40367073

Diagnostic and Prognostic Evaluation of Novel Biomarkers Compared to ESC 0/1 h and 0/3 h Algorithms in Patients with Suspected Non-ST-Elevation Myocardial Infarction., PMID:40363990

Outcome of Cerebral Venous Thrombosis Requiring Mechanical Ventilation., PMID:40363962

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