Catalog No.
DHC15301
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
Fusion - [ALPL (alkaline phosphatase, TNSALP, tissue non-specific alkaline phosphatase) 18-502]2 - IGHG1 Fc (Fragment constant) - Asp-Ile-deca-aspartate
Target
Alkaline phosphatase liver/bone/kidney isozyme, AP-TNAP, TNSALP, Alkaline phosphatase, tissue-nonspecific isozyme, ALPL
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05186
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
ENB-0040, STRENSIQ™
Clone ID
Asfotase alfa
Mobility and Quality of Life in Children with Paediatric-Onset Hypophosphatasia Treated with Asfotase Alfa: Results from UK Managed Access Agreement., PMID:40439960
Phenotypic and Genotypic Spectrum of Indian Patients with Hypophosphatasia., PMID:40416455
Markedly discordant hypophosphatasia in a young girl., PMID:40409424
Severe Hypercalcemia Associated With Perinatal Hypophosphatasia While Receiving Enzyme Replacement Therapy., PMID:40236614
Effects of asfotase alfa on fracture healing of adult patient with hypophosphatasia and literature review., PMID:40189581
Mobility and Quality of Life in Adults with Paediatric-Onset Hypophosphatasia Treated with Asfotase Alfa: Results from UK Managed Access Agreement., PMID:40138164
Safety and efficacy of long term asfotase alfa treatment in childhood hypophosphatasia., PMID:40114282
Effectiveness and safety of asfotase alfa for people with hypophosphatasia: a plain language summary of three studies., PMID:40110697
Medical Management of Hypophosphatasia: Review of Data on Asfotase Alfa., PMID:40100438
Hypophophatasia: the importance of knowing in advance., PMID:40067753
Long-Term Outcomes of Early Enzyme Replacement Therapy With Asfotase Alfa in Perinatal Benign Hypophosphatasia: Amelioration of Bone Deformities in a Young Child., PMID:40051960
Diagnosis and Treatment of Hypophosphatasia., PMID:40047955
Novel therapeutic options for hypophosphatasia., PMID:39893631
Efficacy of asfotase alfa in a patient with adult-onset hypophosphatasia without obvious bone lesions: a case report with review of literature., PMID:39880615
Adult hypophosphatasia presenting with recurrent acute joint pain., PMID:39868560
A Case of Hypophosphatasia Started Enzyme Replacement Therapy Since Babyhood Stage., PMID:39857892
Adult-onset hypophosphatasia diagnosed after consecutive tooth loss during orthodontic treatment: a case report., PMID:39702252
Disproportionality analysis of adverse events associated with asfotase alfa: a post-marketing study using the FDA Adverse Event Reporting System., PMID:39604191
Pain, quality of life, and integral management in a cohort of patients diagnosed with hypophosphatasia in Colombia., PMID:39506814
Longitudinal course of circulating miRNAs in a patient with hypophosphatasia and asfotase alfa treatment: a case report., PMID:39224569
Safety, pharmacokinetics, and pharmacodynamics of efzimfotase alfa, a second-generation enzyme replacement therapy: phase 1, dose-escalation study in adults with hypophosphatasia., PMID:39135540
Challenges in Hypophosphatasia: Suspicion, Diagnosis, Genetics, Management, and Follow-Up., PMID:39102795
Monoclonal antibody anti-sclerostin for treatment of pelvic insufficiency fractures in adult hypophosphatasia: A case report., PMID:39091566
Efficacy and safety of asfotase alfa in patients with hypophosphatasia: A systematic review., PMID:39089608
Improvement in quality of life after asfotase alfa treatment in adults with pediatric-onset hypophosphatasia: data from 5 patient-reported outcome measures., PMID:39006866
Enzyme replacement therapy for hypophosphatasia-The current paradigm., PMID:39004952
A Case of Hypophosphatasia With Normal Alkaline Phosphatase Levels., PMID:38523854
Effectiveness of asfotase alfa for treatment of adults with hypophosphatasia: results from a global registry., PMID:38459585
Impressive clinical improvement and disappearance of neuropathic pain in an adult patient with hypophosphatasia treated with asfotase alfa., PMID:38325645
Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism., PMID:38307176
The Effect of Asfotase Alfa on Plasma and Urine Pyrophosphate Levels and Pseudofractures in a Patient With Adult-Onset Hypophosphatasia., PMID:38130758
Hypophosphatasia: presentation and response to asfotase alfa., PMID:37993691
Cutaneous lesions in the setting of hypophosphatasia., PMID:37965189
Diagnostic and New Therapeutic Approaches to Two Challenging Pediatric Metabolic Bone Disorders: Hypophosphatasia and X-linked Hypophosphatemic Rickets., PMID:37927073
Atypical Femoral Fracture in Hypophosphatasia: A Systematic Review., PMID:37731773
Effect of Asfotase Alfa in the Treatment of Hypophosphatasia- A Systematic Review., PMID:37654393
Management of Craniosynostosis in Lethal Perinatal Hypophosphatasia., PMID:37610006
Effects of asfotase alfa in adults with pediatric-onset hypophosphatasia over 24 months of treatment., PMID:37481150
Chylous ascites complicating perinatal severe hypophosphatasia in an infant on high-setting ventilation and enzyme replacement therapy., PMID:37475513
Hypophosphatasia: from birth to adulthood., PMID:37249457
Prenatal asfotase alfa-mediated enzyme replacement therapy restores delayed calcification in a severe infantile form of hypophosphatasia model mice., PMID:37209904
Asfotase alfa improved skeletal mineralization and fracture healing in a child with MCAHS., PMID:37088336
The impact of enzyme replacement therapy on the oral health manifestations of hypophosphatasia among children: a scoping review., PMID:37036643
Six-year clinical outcomes of enzyme replacement therapy for perinatal lethal and infantile hypophosphatasia in Korea: Two case reports., PMID:36820543
Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP-D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia., PMID:36699639
A Case of Spondylodysplastic Ehlers-Danlos Syndrome With Comorbid Hypophosphatasia., PMID:36447830
Effects of Infantile Hypophosphatasia on Human Dental Tissue., PMID:36414794
Medical Cannabinoids as Treatment for Hypophosphatasia-Related Symptoms., PMID:36380652
For research use only. Not for human or drug use.
