Catalog No.
VHD96701
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
p64, Interleukin-2 receptor subunit gamma, gammaC, IL-2 receptor subunit gamma, CD132, IL-2R subunit gamma, IL-2RG, IL2RG, Cytokine receptor common subunit gamma
Concentration
3.2 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P31785
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0107
Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies., PMID:40132909
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function., PMID:38658764
Implication of 99mTc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells., PMID:36858461
Co-expression IL-15 receptor alpha with IL-15 reduces toxicity via limiting IL-15 systemic exposure during CAR-T immunotherapy., PMID:36167591
Degenerative Myelopathy and Neuropathy in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) Mice Caused by Lactate Dehydrogenase-Elevating Virus (LDV)., PMID:35450478
Peptide nucleic acid-dependent artifact can lead to false-positive triplex gene editing signals., PMID:34732575
CD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull mice., PMID:34616589
A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells., PMID:34011961
Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells., PMID:33647370
Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species., PMID:33328333
Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins., PMID:32582190
Reinforcing involvement of NK cells in psoriasiform dermatitis animal model., PMID:31798717
Gene correction for SCID-X1 in long-term hematopoietic stem cells., PMID:30967552
Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing., PMID:30018062
Human CD8+CD28- T Suppressor Cells Expanded by IL-15 In Vitro Suppress in an Allospecific and Programmed Cell Death Protein 1-Dependent Manner., PMID:29988346
Nuclease-free Adeno-Associated Virus-Mediated Il2rg Gene Editing in X-SCID Mice., PMID:29606506
Cutting Edge: Differential Fine-Tuning of IL-2- and IL-15-Dependent Functions by Targeting Their Common IL-2/15Rβ/γc Receptor., PMID:28507024
ABCB5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth., PMID:26827764
CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells., PMID:26413784
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum., PMID:26183780
Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells., PMID:25475707
In vivo maintenance of human regulatory T cells during CD25 blockade., PMID:25416807
Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells., PMID:24786312
Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera., PMID:24512738
Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells., PMID:24462799
Infectious bursal disease virus influences the transcription of chicken γc and γc family cytokines during infection., PMID:24416239
Human CD8+ memory and EBV-specific T cells show low alloreactivity in vitro and in CD34+ stem cell-engrafted NOD/SCID/IL-2Rγc null mice., PMID:24120693
Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage., PMID:23963040
Application of IL-2 therapy to target T regulatory cell function., PMID:22951308
Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor., PMID:22737248
Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor., PMID:22645657
Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient., PMID:22460439
Identity, potency, in vivo viability, and scaling up production of lentiviral vector-induced dendritic cells for melanoma immunotherapy., PMID:22428979
The influence of HIV on CD127 expression and its potential implications for IL-7 therapy., PMID:22421574
Identification of T-lymphocytic leukemia-initiating stem cells residing in a small subset of patients with acute myeloid leukemic disease., PMID:21562049
Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia., PMID:21487100
FK506 causes cellular and functional defects in human natural killer cells., PMID:20671192
Expression of interleukin-21, interleukin-21 receptor alpha and related type I cytokines by intravascular graft leukocytes during acute renal allograft rejection., PMID:19159826
Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma., PMID:19155487
In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein., PMID:18791162
Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera., PMID:18589435
Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations., PMID:17598841
Interleukin-2 augmented activation of tumor associated macrophage plays the main role in MHC class I in vivo induction in tumor cells that are MHC negative in vitro., PMID:16596236
CD8+ T cells in HIV disease exhibit cytokine receptor perturbation and poor T cell receptor activation but are responsive to gamma-chain cytokine-driven proliferation., PMID:16479523
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells., PMID:15879151
A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma., PMID:15811959
Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy., PMID:15668127
Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia., PMID:15590396
In vivo and in vitro roles of IL-21 in inflammation., PMID:15585879
Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo., PMID:12531798
For research use only. Not for human or drug use.
