Catalog No.
RXX08201
Species reactivity
Staphylococcus aureus (strain COL), Staphylococcus aureus (strain NCTC 8325 / PS 47), Staphylococcus aureus (strain NCTC 8325 / PS 47), Staphylococcus aureus (strain COL)
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
Cytotoxin LukAB, Leukocidin LukGH, LukG, LukA, Leukocidin G, Bi-component leukocidin LukGH subunit G, LukH, LukB, Leukocidin H, Bi-component leukocidin LukGH subunit H, Staphylococcus aureus
Concentration
1.58 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P21224
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0520
A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models., PMID:40254611
Staphylococcal γ-hemolysins induce IL-4 production in murine basophils., PMID:36206594
Development of Combination Vaccine Conferring Optimal Protection against Six Pore-Forming Toxins of Staphylococcus aureus., PMID:34227839
IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus., PMID:33777005
Associations of pathogen-specific and host-specific characteristics with disease outcome in patients with Staphylococcus aureus bacteremic pneumonia., PMID:31360464
Rational Design of Toxoid Vaccine Candidates for Staphylococcus aureus Leukocidin AB (LukAB)., PMID:31207937
Preventing lung pathology and mortality in rabbit Staphylococcus aureus pneumonia models with cytotoxin-neutralizing monoclonal IgGs penetrating the epithelial lining fluid., PMID:30926865
Serologic Detection of Antibodies Targeting the Leukocidin LukAB Strongly Predicts Staphylococcus aureus in Children With Invasive Infection., PMID:29538707
Commercial Intravenous Immunoglobulin Preparations Contain Functional Neutralizing Antibodies against the Staphylococcus aureus Leukocidin LukAB (LukGH)., PMID:28874371
Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and Modes of Action., PMID:28186295
Humanized Mice Exhibit Increased Susceptibility to Staphylococcus aureus Pneumonia., PMID:27638942
Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies., PMID:27467113
Host response to Staphylococcus aureus cytotoxins in children with cystic fibrosis., PMID:26821814
Antibodies to S. aureus LukS-PV Attenuated Subunit Vaccine Neutralize a Broad Spectrum of Canonical and Non-Canonical Bicomponent Leukotoxin Pairs., PMID:26367030
Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin., PMID:26307164
Children with invasive Staphylococcus aureus disease exhibit a potently neutralizing antibody response to the cytotoxin LukAB., PMID:24379282
For research use only. Not for human or drug use.
