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Anti-HPV16 L2/Minor capsid protein L2 Antibody (MAb24B)

Catalog #:   RVV20801 Specific References (119) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: ELISA, WB
Accession: P03107
Overview

Catalog No.

RVV20801

Species reactivity

Human papillomavirus type (HPV16, HPV18, HPV31, HPV33, HPV35, HPV51, HPV52, HPV58)

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Minor capsid protein L2, L2

Concentration

2.44 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P03107

Applications

ELISA, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

MAb24B

Data Image
  • Bioactivity
    Detects Human papillomavirus type 16 L2/Minor capsid protein L2 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for HPV16 L2/Minor capsid protein L2 Antibody (MAb24B)
References

Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas. PMID: 36680181

A Current Update on Human Papillomavirus-Associated Head and Neck Cancers. PMID: 31600915

Integrated genomic and molecular characterization of cervical cancer. PMID: 36214947

Detection of HPV16 viral load in L2 gene as a related predictor of cervical cancer among women in Dhi-Qar province by qRT-PCR. PMID: 36750540

Retraction Note: Detection of HPV16 viral load in L2 gene as a related predictor of cervical cancer among women in Dhi-Qar province by qRT-PCR. PMID: 25972404

Seroepidemiology of Human Papillomavirus 16 (HPV16) L2 and Generation of L2-Specific Human Chimeric Monoclonal Antibodies. PMID: 26925750

HPV16 L2 improves HPV16 L1 gene delivery as an important approach for vaccine design against cervical cancer. PMID: 23762404

Differential expression of HPV16 L2 gene in cervical cancers harboring episomal HPV16 genomes: influence of synonymous and non-coding region variations. PMID: 32510304

Correlation between cervical HPV DNA detection and HPV16 seroreactivity measured with L1-only and L1+L2 viral capsid antigens. PMID: 35763643

Human Papillomavirus Type 16 L2 Gene Sequence Variation Analysis in Indonesian Cervical Cancer Specimens. PMID: 29207600

Host cell transcriptome modification upon exogenous HPV16 L2 protein expression. PMID: 22154072

The high risk HPV16 L2 minor capsid protein has multiple transport signals that mediate its nucleocytoplasmic traffic. PMID: 23689062

L2, the minor capsid protein of papillomavirus. PMID: 24928042

The nuclear retention signal of HPV16 L2 protein is essential for incoming viral genome to transverse the trans-Golgi network. PMID: 35458534

Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection. PMID: 23335178

HPV16 L1 and L2 DNA methylation predicts high-grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology. PMID: 34960729

HPV16 Entry into Epithelial Cells: Running a Gauntlet. PMID: 33802456

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates. PMID: 35891458

HPV16 Induces Formation of Virus-p62-PML Hybrid Bodies to Enable Infection. PMID: 33568731

High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility. PMID: 27889616

Developments in L2-based human papillomavirus (HPV) vaccines. PMID: 27122588

Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins. PMID: 19860897

Role of L2 cysteines in papillomavirus infection and neutralization. PMID: 27654294

The Cytoskeletal Adaptor Obscurin-Like 1 Interacts with the Human Papillomavirus 16 (HPV16) Capsid Protein L2 and Is Required for HPV16 Endocytosis. PMID: 35193933

ISA101 and nivolumab for HPV-16+ cancer: updated clinical efficacy and immune correlates of response. PMID: 34516991

Immunological responses and anti-tumor effects of HPV16/18 L1-L2-E7 multiepitope fusion construct along with curcumin and nanocurcumin in C57BL/6 mouse model. PMID: 23388722

The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs. PMID: 28056100

Chimeric L2-Based Virus-Like Particle (VLP) Vaccines Targeting Cutaneous Human Papillomaviruses (HPV). PMID: 17980618

Transient expression of HPV16 E7 peptide (aa 44-60) and HPV16 L2 peptide (aa 108-120) on chimeric potyvirus-like particles using Potato virus X-based vector. PMID: 17239496

A papillomavirus-like particle (VLP) vaccine displaying HPV16 L2 epitopes induces cross-neutralizing antibodies to HPV11. PMID: 22761884

Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate. PMID: 24444361

An L2 SUMO interacting motif is important for PML localization and infection of human papillomavirus type 16. PMID: 14505907

Safety and immunogenicity of a peptide containing the cross-neutralization epitope of HPV16 L2 administered nasally in healthy volunteers. PMID: 26569287

Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection. PMID: 12560332

Interaction of L2 with beta-actin directs intracellular transport of papillomavirus and infection. PMID: 20684966

Inhibition of nuclear entry of HPV16 pseudovirus-packaged DNA by an anti-HPV16 L2 neutralizing antibody. PMID: 34740725

A respirable HPV-L2 dry-powder vaccine with GLA as amphiphilic lubricant and immune-adjuvant. PMID: 31743367

Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome. PMID: 35608352

Human Papillomavirus Minor Capsid Protein L2 Mediates Intracellular Trafficking into and Passage beyond the Endoplasmic Reticulum. PMID: 17010405

Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface region. PMID: 21346798

Cross-neutralization potential of native human papillomavirus N-terminal L2 epitopes. PMID: 33238224

Genetic signatures for lineage/sublineage classification of HPV16, 18, 52 and 58 variants. PMID: 19214230

Two highly conserved cysteine residues in HPV16 L2 form an intramolecular disulfide bond and are critical for infectivity in human keratinocytes. PMID: 12610128

Cell surface-binding motifs of L2 that facilitate papillomavirus infection. PMID: 17150135

Serum antibody response to Human papillomavirus (HPV) infections detected by a novel ELISA technique based on denatured recombinant HPV16 L1, L2, E4, E6 and E7 proteins. PMID: 10712890

Human papillomavirus vaccines. PMID: 18508629

HPV-16 RNA processing. PMID: 27518844

Human Papillomavirus Type 16 L2 DNA Methylation in Exfoliated Cervical Cells From College-Age Women. PMID: 36263027

Next generation L2-based HPV vaccines cross-protect against cutaneous papillomavirus infection and tumor development. PMID: 22927980

The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection. PMID: 29212932

Minor Capsid Protein L2 Polytope Induces Broad Protection against Oncogenic and Mucosal Human Papillomaviruses. PMID: 26362430

Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine approach. PMID: 28463988

Translocation of the papillomavirus L2/vDNA complex across the limiting membrane requires the onset of mitosis. PMID: 36815785

Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16. PMID: 27398412

Involvement of Nucleophosmin (NPM1/B23) in Assembly of Infectious HPV16 Capsids. PMID: 15507604

The l2 minor capsid protein of human papillomavirus type 16 interacts with a network of nuclear import receptors. PMID: 11158207

Papillomavirus-like particle vaccines. PMID: 29207511

Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2. PMID: 30996086

Phosphorylation of Human Papillomavirus Type 16 L2 Contributes to Efficient Virus Infectious Entry. PMID: 20334659

Papillomavirus pseudovirions packaged with the L2 gene induce cross-neutralizing antibodies. PMID: 11287582

L1 interaction domains of papillomavirus l2 necessary for viral genome encapsidation. PMID: 30926288

Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer. PMID: 19368776

Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20 -- 38) peptide displayed on bacterial thioredoxin. PMID: 27725301

Genomic diversity and phylogenetic relationships of human papillomavirus 16 (HPV16) in Nepal. PMID: 23383218

Optimization of multimeric human papillomavirus L2 vaccines. PMID: 30946955

The endocytic trafficking pathway of oncogenic papillomaviruses. PMID: 29914845

Adenovirus based HPV L2 vaccine induces broad cross-reactive humoral immune responses. PMID: 22351779

Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo. PMID: 24662712

A three component mix of thioredoxin-L2 antigens elicits broadly neutralizing responses against oncogenic human papillomaviruses. PMID: 18367526

Advances on two serological assays for human papillomavirus provide insights on the reactivity of antibodies against a cross-neutralization epitope of the minor capsid protein L2., PMID:38022617

Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope., PMID:37798448

Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas., PMID:36680181

Next generation L2-based HPV vaccines cross-protect against cutaneous papillomavirus infection and tumor development., PMID:36263027

RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer., PMID:35703545

Genetic variability in minor capsid protein (L2 gene) of human papillomavirus type 16 among Indian women., PMID:35552511

Dissolving Microneedle Delivery of a Prophylactic HPV Vaccine., PMID:35139303

RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates., PMID:33802456

Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP., PMID:33573433

Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists., PMID:33309485

Comprehensive Assessment of the Antigenic Impact of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised against Lineage A Major Capsid Proteins of Vaccine-Related Genotypes., PMID:32967963

Correlation between cervical HPV DNA detection and HPV16 seroreactivity measured with L1-only and L1+L2 viral capsid antigens., PMID:32510304

Production and Preliminary In Vivo Evaluations of a Novel in silico-designed L2-based Potential HPV Vaccine., PMID:31729940

Incorporation of RG1 epitope into HPV16L1-VLP does not compromise L1-specific immunity., PMID:31147274

Phosphorylation of Human Papillomavirus Type 16 L2 Contributes to Efficient Virus Infectious Entry., PMID:30996086

Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer., PMID:30926288

VLP Production from Recombinant L1/L2 HPV-16 Protein Expressed in Pichia Pastoris., PMID:30091403

Adenovirus based HPV L2 vaccine induces broad cross-reactive humoral immune responses., PMID:29914845

A Dual-Type L2 11-88 Peptide from HPV Types 16/18 Formulated in Montanide ISA 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated with High Titers of Broad Spectrum Cross-Reactive Antibodies in Vaccinated Mice., PMID:29854852

Roles of Fc Domain and Exudation in L2 Antibody-Mediated Protection against Human Papillomavirus., PMID:29743371

Displaying 31RG-1 peptide on the surface of HPV16 L1 by use of a human papillomavirus chimeric virus-like particle induces cross-neutralizing antibody responses in mice., PMID:29683766

Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles., PMID:29269879

Minor Capsid Protein L2 Polytope Induces Broad Protection against Oncogenic and Mucosal Human Papillomaviruses., PMID:29212932

High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16., PMID:29211035

Human papillomavirus 16L1-58L2 chimeric virus-like particles elicit durable neutralizing antibody responses against a broad-spectrum of human papillomavirus types., PMID:28968993

Immunization of mice by a multimeric L2-based linear epitope (17-36) from HPV type 16/18 induced cross reactive neutralizing antibodies., PMID:28855937

Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes., PMID:28778613

Impact of naturally occurring variation in the human papillomavirus (HPV) 33 capsid proteins on recognition by vaccine-induced cross-neutralizing antibodies., PMID:28691664

Human Papillomavirus Major Capsid Protein L1 Remains Associated with the Incoming Viral Genome throughout the Entry Process., PMID:28566382

A plant protein signal sequence improved humoral immune response to HPV prophylactic and therapeutic DNA vaccines., PMID:28118086

Developments in L2-based human papillomavirus (HPV) vaccines., PMID:27889616

Comparison of human papillomavirus type 16 replication in tonsil and foreskin epithelia., PMID:27639574

Broad Cross-Protection Is Induced in Preclinical Models by a Human Papillomavirus Vaccine Composed of L1/L2 Chimeric Virus-Like Particles., PMID:27147749

Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes., PMID:27113165

A Live Vector Expressing HPV16 L1 Generates an Adjuvant-Induced Antibody Response In-vivo., PMID:26855722

Production of Human papillomavirus pseudovirions in plants and their use in pseudovirion-based neutralisation assays in mammalian cells., PMID:26853456

Humoral Immune Response Against Human Papillomavirus as Source of Biomarkers for the Prediction and Detection of Cervical Cancer., PMID:26780189

Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes., PMID:26382603

Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine approach., PMID:26362430

Robust In Vitro and In Vivo Neutralization against Multiple High-Risk HPV Types Induced by a Thermostable Thioredoxin-L2 Vaccine., PMID:26170394

Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination., PMID:26113972

Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2., PMID:26003490

Seroepidemiology of Human Papillomavirus 16 (HPV16) L2 and Generation of L2-Specific Human Chimeric Monoclonal Antibodies., PMID:25972404

Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody., PMID:25905781

A chimeric 18L1-45RG1 virus-like particle vaccine cross-protects against oncogenic alpha-7 human papillomavirus types., PMID:25790098

Amino acid motifs in both the major and minor capsid proteins of HPV51 impact antigenicity and infectivity., PMID:25770119

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer., PMID:25560237

Measurement of neutralizing serum antibodies of patients vaccinated with human papillomavirus L1 or L2-based immunogens using furin-cleaved HPV Pseudovirions., PMID:24999962

Immunization with a consensus epitope from human papillomavirus L2 induces antibodies that are broadly neutralizing., PMID:24962748

The use of hybrid virus-like particles to enhance the immunogenicity of a broadly protective HPV vaccine., PMID:24917327

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-HPV16 L2/Minor capsid protein L2 Antibody (MAb24B) [RVV20801]
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