Anti-Human PDGFC Antibody (SAA0450)

Catalog No.

FHJ65710

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

Spinal cord-derived growth factor, PDGFC receptor-binding form, SCDGF, PDGFC latent form, Fallotein, PDGF-C, VEGF-E, Platelet-derived growth factor C, PDGFC

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NRA1

Applications

ELISA, FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.09% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA0450

PDGFRα inhibition reduces myofibroblast expansion in the fibrotic rim and enhances recovery after ischemic stroke., PMID:39808499

Targeting PDGF-CC as a promising therapeutic strategy to inhibit cholangiocarcinoma progression., PMID:39543636

Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse., PMID:36914817

Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation., PMID:35163520

Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier., PMID:33361796

Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction., PMID:32574573

Chemotherapeutic and antiangiogenic drugs beyond tumor progression in colon cancer: Evaluation of the effects of switched schedules and related pharmacodynamics., PMID:30953637

Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension., PMID:30827511

Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo., PMID:30052660

Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CChum mice., PMID:30021009

Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model., PMID:29850586

Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1., PMID:28977999

Homocysteine Facilitates Prominent Polygonal Angiogenetic Networks of a Choroidal Capillary Sprouting Model., PMID:28806447

PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently., PMID:27788490

[Primary culture and characteristics of colorectal cancer-associated fibroblasts]., PMID:26702529

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration., PMID:26687981

Role of platelet-derived growth factor-CC in capillary rarefaction in renal fibrosis., PMID:26216283

Naturally occurring PDGF receptor inhibitors with potential anti-atherosclerotic properties., PMID:25737405

Genome-wide association study of antibody level response to NDV and IBV in Jinghai yellow chicken based on SLAF-seq technology., PMID:25588649

Accelerated wound closure in vitro by fibroblasts from a subgroup of cleft lip/palate patients: role of transforming growth factor-α., PMID:25360592

Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness., PMID:24126726

Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma., PMID:23929039

Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice., PMID:23856609

Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments., PMID:23338608

Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis., PMID:23141925

Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy., PMID:22238384

Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer., PMID:21224365

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets., PMID:20566880

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation., PMID:20231377

PDGF-CC induces tissue factor expression: role of PDGF receptor alpha/beta., PMID:19795151

Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy., PMID:19754219

Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors., PMID:19366796

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment., PMID:19352490

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts., PMID:19118022

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment., PMID:19111878

Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy., PMID:19111874

PDGF receptors are activated in human epiretinal membranes., PMID:19032953

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke., PMID:18568034

PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis., PMID:18184860

Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy., PMID:18172073

PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines., PMID:18055825

PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells., PMID:17066417

PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid., PMID:16956736

Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma., PMID:16675559

Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells., PMID:16612331

Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation., PMID:15611105

Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts., PMID:15389578

PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases., PMID:12707385

v-erbA oncogene induces invasiveness and anchorage-independent growth in cultured glial cells by mechanisms involving platelet-derived growth factor., PMID:8838867

Radioimmunoassay of epidermal growth factor in human saliva and gastric juice., PMID:2040084

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