Catalog No.
FHD49510
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
VG-1-R, VG-1-related protein, Bone morphogenetic protein 6, VGR-1, BMP-6, VGR, BMP6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P22004
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0425
Pulmonary Microvascular Endothelial Cells Support Alveolar Epithelial Growth via Bone Morphogenetic Protein 6 Secretion., PMID:40439543
A Recombinant Antibody Against ALK2 Promotes Tissue Iron Redistribution and Contributes to Anemia Resolution in a Mouse Model of Anemia of Inflammation., PMID:39791515
Involvement of mitogen- and stress-activated protein kinase 1 in BMP-6-induced chondrocyte differentiation., PMID:39307301
Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva., PMID:38397414
ACVR1: A Novel Therapeutic Target to Treat Anemia in Myelofibrosis., PMID:38201581
Vitiligo progression in a patient undergoing romosozumab treatment for osteoporosis., PMID:37965188
Sputum Cytokine Profiling in COPD: Comparison Between Stable Disease and Exacerbation., PMID:36017119
Adrenergic receptor behaviors of mesenchymal stem cells obtained from different tissue sources and the effect of the receptor blockade on differentiation., PMID:34323168
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities., PMID:33480423
BMP6 Regulates Corneal Epithelial Cell Stratification by Coordinating Their Proliferation and Differentiation and Is Upregulated in Pterygium., PMID:32845956
The Influence of Adalimumab and Cyclosporine A on the Expression Profile of the Genes Related to TGFβ Signaling Pathways in Keratinocyte Cells Treated with Lipopolysaccharide A., PMID:32774143
A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures., PMID:32730930
Recombinant Human BMP6 Applied Within Autologous Blood Coagulum Accelerates Bone Healing: Randomized Controlled Trial in High Tibial Osteotomy Patients., PMID:32543706
A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease., PMID:32438400
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia., PMID:31899794
Reduction of BMP6-induced bone formation by calcium phosphate in wild-type compared with nude mice., PMID:30815997
Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease., PMID:30677788
Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells., PMID:30372497
Erythroferrone inhibits the induction of hepcidin by BMP6., PMID:30097509
Bone Morphogenetic Protein 6 Polymorphisms are Associated With Systemic Lupus Erythematosus Susceptibility in the Korean Population., PMID:30874244
Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6., PMID:28815688
The importance of BMP6 marker within the process of epithelial-mesenchymal transition in the pleomorphic adenoma of the salivary gland., PMID:28523310
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5., PMID:28489883
Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts., PMID:28203489
Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis., PMID:27046124
Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats., PMID:26845567
Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation., PMID:26635037
Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model., PMID:26252391
KGF and BMP-6 intervene in cellular reprogramming and in mesenchymal-epithelial transition (MET) of 3T3L1 mouse adipose cells., PMID:25492426
Stromal TGF-β signaling induces AR activation in prostate cancer., PMID:25333263
Hepcidin antagonists for potential treatments of disorders with hepcidin excess., PMID:24808863
Low-intensity pulsed ultrasound induces osteogenic differentiation of human periodontal ligament cells through activation of bone morphogenetic protein-smad signaling., PMID:24764342
Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway., PMID:24746831
E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling., PMID:24488011
The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary., PMID:24406789
Mechanism of pro-tumorigenic effect of BMP-6: neovascularization involving tumor-associated macrophages and IL-1a., PMID:24185914
Association of bone morphogenetic protein 6 with exocrine gland dysfunction in patients with Sjögren's syndrome and in mice., PMID:23982860
Bone morphogenetic protein-6 induces castration resistance in prostate cancer cells through tumor infiltrating macrophages., PMID:23710822
An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland., PMID:22538126
Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells., PMID:22366471
Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation., PMID:22290531
Chondrogenesis from umbilical cord blood cells stimulated with BMP-2 and BMP-6., PMID:22238025
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7., PMID:21898381
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice., PMID:21622652
Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction., PMID:21571370
Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis., PMID:21415150
Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6-IL6 Loop., PMID:21374653
The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease., PMID:21351217
Healing of tooth extraction sockets in the streptozotocin diabetic rat model: Induction of cartilage by BMP-6., PMID:20969540
Iron overload induces BMP6 expression in the liver but not in the duodenum., PMID:20952515
For research use only. Not for human or drug use.
