Catalog No.
VHH37201
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
Membrane antigen MN, P54/58N, Carbonic anhydrase 9, Renal cell carcinoma-associated antigen G250, CA-IX, CAIX, pMW1, Carbonic anhydrase IX, RCC-associated antigen G250, Carbonate dehydratase IX, CA9, MN, G250
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16790
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0098
Small Organic Carbonic Anhydrase IX Ligands from DNA-Encoded Chemical Libraries for Tumor-Targeted Delivery of Radionuclides., PMID:40378292
Pharmacological inhibition of hypoxia induced acidosis employing a CAIX inhibitor sensitizes gemcitabine resistant PDAC cells., PMID:40369181
NRF1-Induced lncRNA DDX11-AS1 Contributes to the Progression of Hepatocellular Carcinoma via Activating CA9 Expression and the MEK/ERK Pathway., PMID:40356690
Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors., PMID:40337848
Synthesis and Construction of I-124 Labeled Small Molecular Probe for Noninvasive PET Imaging of CAIX Expression., PMID:40205275
Targeted Human Editing Using CRISPR Technology in Neural Stem Cells., PMID:40067628
METTL3 enhances esophageal squamous cell carcinoma progression by suppressing ferroptosis through the PBX3/CA9 cascade., PMID:40048803
Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma., PMID:39936451
Carbonic anhydrase IX inhibition as a path to treat neuroblastoma., PMID:39776083
[A commentary: New carbonic anhydrase IX-targeted probes for imaging hypoxic tumors]., PMID:39690094
Novel Anti-Tumor Effect of Natural Products from Aloe vera Resin and their In-Vitro/In-Silico Targeting Mechanism of Carbonic Anhydrase-II and IX., PMID:39440953
A Smart CA IX-Targeting and pH-Responsive Nano-Mixed Micelles for Delivery of FB15 with Superior Anti-Breast Cancer Efficacy., PMID:39403708
Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer., PMID:39207927
KIAA1429 promotes the malignancy of oral squamous cell carcinoma by regulating CA9 m6A methylation., PMID:39188646
Rhopaloic acid A triggers mitochondria damage-induced apoptosis in oral cancer by JNK/BNIP3/Nix-mediated mitophagy., PMID:39043083
Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer., PMID:38941699
Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma., PMID:38834201
A CAIX Dual-Targeting Small-Molecule Probe for Noninvasive Imaging of ccRCC., PMID:38831541
Development of carbonic anhydrase IX-targeting molecular-targeted photodynamic therapy., PMID:38810709
Dectin-1/SYK Activation Induces Antimicrobial Peptide and Negative Regulator of NF-κB Signaling in Human Oral Epithelial Cells., PMID:38688646
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles., PMID:38642371
LINC02086 inhibits ferroptosis and promotes malignant phenotypes of pancreatic cancer via miR-342-3p/CA9 axis., PMID:38438595
Investigating the molecular mechanism of Qizhu anticancer prescription in inhibiting hepatocellular carcinoma based on high-resolution mass spectrometry and network pharmacology., PMID:38417600
Hypoxia-related carbonic anhydrase 9 induces serpinB9 expression in cancer cells and apoptosis in T cells via acidosis., PMID:38413363
LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma., PMID:38177154
Arenobufagin increases the sensitivity of gastric cancer to cisplatin via alkaliptosis., PMID:37920505
Controlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions., PMID:37873449
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer., PMID:37748406
Verbascoside: A neuroprotective phenylethanoid glycosides with anti-depressive properties., PMID:37657207
Functional consequences of altered glycosylation of tumor-associated hypoxia biomarker carbonic anhydrase IX., PMID:37498074
Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway., PMID:37476191
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9., PMID:37210768
Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer., PMID:37098526
Butyrate-treatment induces gingival epithelial cell death in a three-dimensional gingival-connective tissue hybrid co-culture system., PMID:37021231
Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage., PMID:36901744
Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis., PMID:36748885
IGFL2-AS1-induced suppression of HIF-1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9., PMID:36537608
Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells., PMID:36380966
Harnessing insect olfactory neural circuits for detecting and discriminating human cancers., PMID:36327558
Tissue oxygenation stabilizes neovessels and mitigates hemorrhages in human atherosclerosis-induced angiogenesis., PMID:35947328
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia., PMID:35726024
OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis., PMID:35440019
Possible Action of Olaparib for Preventing Invasion of Oral Squamous Cell Carcinoma In Vitro and In Vivo., PMID:35269669
CA9-Related Acidic Microenvironment Mediates CD8+ T Cell Related Immunosuppression in Pancreatic Cancer., PMID:35155218
ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer., PMID:34904929
DC-CTL targeting carbonic anhydrase IX gene combined with iAPA therapy in the treatment of renal cell carcinoma., PMID:34851805
A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity., PMID:34842317
[6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway., PMID:34697150
Generating a new mouse model for nuclear PTEN deficiency by a single K13R mutation., PMID:34661323
A novel 111indium-labeled dual carbonic anhydrase 9-targeted probe as a potential SPECT imaging radiotracer for detection of hypoxic colorectal cancer cells., PMID:34450241
For research use only. Not for human or drug use.
