InVivoMAb Anti-Human BDNF (Iv0093)

Catalog No.

VHD59401

Species reactivity

Human

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

ProBDNF, Abrineurin, Brain-derived neurotrophic factor, BDNF

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P23560

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0093

The Role of Epigenetics in Manganese Neurotoxicity: An Update with a Focus on Non-Coding RNAs and Histone Modifications., PMID:40498345

Altered Neuroplasticity in Epilepsy is Associated with Neuroinflammation and Oxidative Stress: In vivo Evidence of Brain-Derived Extracellular Vesicles., PMID:40491852

Ketamine-induced sustained modulation of GABAA receptor function in mouse hippocampal neurons following anesthesia., PMID:40489634

Co-delivery of neurotrophic factors and a zinc chelator substantially increases retinal ganglion cell survival and axon protection in the optic nerve crush model., PMID:40482982

GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer's disease., PMID:40468230

Mechanistic insights into a thermoresponsive in situ nanoemulgel of azilsartan medoxomil for intranasal delivery: a promising nanotherapeutic approach to target dementia., PMID:40459925

TLR4 as a therapeutic target: Antidepressant mechanism of saikosaponin A in regulating the NF-κB/BDNF axis and mitigating oxidative stress and inflammation in vivo and in vitro., PMID:40453654

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age., PMID:40449249

Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation., PMID:40447013

Kai-Xin-San ameliorates fluoxetine-resistant depressive-like behaviors by modulating tryptophan-kynurenine metabolic homeostasis in a rodent model., PMID:40446976

MiR-134-5p/BDNF/TrkB/CREB signaling pathway involved in the depression-like behaviors in mice following exposure to benzo[a]pyrene., PMID:40407953

The leptin/BDNF/TrkB signaling pathway improves corticosteroid combined with chronic restraint stress-induced depressive-like behavior in mice., PMID:40389053

Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis., PMID:40381500

Neurotrophins of the retina and their involvement in early-stage diabetic retinopathy in an animal model of type 1 diabetes mellitus., PMID:40368327

High-Efficiency Ocular Delivery of Brain-Derived Neurotrophic Factor and Oligomycin for Neuroprotection in Glaucoma., PMID:40357695

Behavioral and Neuroprotective Properties of the Phytoestrogen 8-Prenylnaringenin (8-PN) in Ovariectomized Mice., PMID:40344590

Neuroprotective mechanism of hydrogen sulfide in okadaic acid-induced alzheimer-like pathology., PMID:40341601

Optimizing Factors in Murine Whole-Organ Cochlea Culture., PMID:40332783

Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation., PMID:40312965

Expression of BDNF in the Cortex and Hippocampus of Mice With Middle Cerebral Artery Occlusion., PMID:40294991

SDF2L1 downregulation mediates high glucose-caused Schwann cell dysfunction by inhibiting nuclear import of TFEB and CREB via KPNA3., PMID:40294738

Artemisinin alleviates ischemic stroke injury and promotes neurogenesis through PPARγ-mediated M2 polarization of microglia., PMID:40286750

Therapeutic Targets and Molecular Mechanisms of Calycosin in the Treatment of Depression: Insights From Chronic Mild Stress Animal Models., PMID:40260589

Inhibition of tRF- 02514 in Extracellular Vesicles Preserves Microglia Pyroptosis and Protects Against Parkinson's Disease., PMID:40254704

5,7,3',4',5'-pentamethoxyflavone (PMF) exhibits anti-obesity and neuroprotective effects in an obese zebrafish model., PMID:40252912

Identification of preventive biomarkers associated with circadian rhythms in traumatic brain injury-mediated depression: Expression of SERPINE1 protein and bioinformatics analysis., PMID:40246101

Rumex acetosa L. enhance learning and cognitive function by modulating NMDA receptor and BDNF pathways in vitro and in vivo., PMID:40244509

Implementing potential biomarkers for early detection of retinal changes in Parkinson's disease: Preliminary study on BDNF role., PMID:40241602

MiR-223-3p inhibits hippocampal neurons injury and exerts anti- anxiety/depression-like behaviors by directly targeting NLRP3., PMID:40237808

Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis., PMID:40236845

Acupuncture alleviates CSDS-induced depressive-like behaviors by modulating synaptic plasticity in vCA1., PMID:40225589

A brain-accessible peptide modulates stroke inflammatory response and neurotoxicity by targeting BDNF-receptor TrkB-T1 specific interactome., PMID:40225562

The microglial state transition as a novel mechanism by which fresh Baihe Dihuang decoction prevents depression by regulating SIRT1/HMGB1 signaling., PMID:40220404

Withania somnifera Regulates Mitochondrial Biogenesis and Energetics in Rat Cortical Neurons: Role of BDNF and SIRT1., PMID:40199807

PRDX1 affects acrylamide-induced neural damage through the PTEN/AKT signaling pathway., PMID:40189060

Exploration of the Therapeutic Potential of the Epigenetic Modulator Decitabine on 6-OHDA-Induced Experimental Models of Parkinson's Disease., PMID:40179313

Revealing the effective components and mechanism of Zhimu-Huangbai herb-pair in the treatment of Alzheimer's disease., PMID:40154898

Chaihu-Shugan-San alleviates post-stroke depression in mice: Mechanistic insights into exosome-mediated neuroprotection., PMID:40154896

Inhibition of TrkB-BDNF positive feedback loop attenuates intervertebral disc degeneration and low back pain in a composite mouse model., PMID:40147506

TrkB signaling promotes alveolar capillary angiogenesis following perinatal hyperoxic damage., PMID:40125780

BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway., PMID:40122822

Platelet factor 4 attenuates inflammation of microglia and protects retinal ganglion cells in retinal excitotoxicity., PMID:40118133

In Vivo Tracking of Amniotic Fluid Derived Stem Cells on Acellular Nerve Graft., PMID:40117437

Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway., PMID:40114280

Spermidine Inhibits M1 Microglia Polarization in a Mouse Model of Parkinson's Disease and BV2 Cells via NF-κB/STAT-1 Pathway., PMID:40059454

Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise., PMID:40059099

TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice., PMID:40049315

BDNF-mediated depressor response by direct baroreceptor activation benefits for prevention and control of hypertension in high-latitude cold region., PMID:40037144

Mechanistic insights into microwave radiation induced cognitive impairments: The role of m6A epigenetic modifications and HNRNPA2B1 in TrkB regulation., PMID:39999628

Dual recombinase-mediated intersectional genetics defines the functional heterogeneity of neural stem cells in adult hippocampus., PMID:39994425

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