InVivoMAb Anti-Human HBEGF (Iv0076)

Catalog No.

VHJ42901

Species reactivity

Human

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

DTR, DT-R, DTS, HEGFL, HB-EGF, HBEGF, Proheparin-binding EGF-like growth factor, Diphtheria toxin receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q99075

Applications

ELISA, FCM, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0076

Matrix metalloproteinase-10 promotes kidney fibrosis by transactivating β-catenin signaling., PMID:40382334

Exogenous administration of heparin-binding epidermal growth factor-like growth factor improves erectile function in mice with bilateral cavernous nerve injury., PMID:40247713

Pd Icosahedral Nanoparticles Promote Skin Wound Healing by Enhancing SP1-HBEGF Axis-Mediated Keratinocytes Proliferation., PMID:40093544

Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm., PMID:39960839

MiR-5586-5p Suppresses Hypoxia-induced Angiogenesis Through Multiple Targeting of HIF-1α, HBEGF and ADAM17 in Breast Cancer., PMID:39890164

Stretch-induced hepatic endothelial mechanocrine promotes hepatocyte proliferation., PMID:39250438

In vitro, ex vivo, instrumental and clinical evaluation of a topical cream on the signs of periorbital ageing., PMID:39119663

Heparin-binding epidermal growth factor-like growth factor improves erectile function in streptozotocin-induced diabetic mice., PMID:39033084

LMWH prevents thromboinflammation in the placenta via HBEGF-AKT signaling., PMID:38941535

Transcriptomic analysis of Porphyromonas gingivalis-infected head and neck cancer cells: Identification of PLAU as a candidate prognostic biomarker., PMID:38363001

The interplay of Cxcl10+/Mmp14+ monocytes and Ccl3+ neutrophils proactively mediates silica-induced pulmonary fibrosis., PMID:38335607

An essential signaling cascade for avian auditory hair cell regeneration., PMID:38128539

Endothelial Notch Signaling Regulates the Function of the Retinal Pigment Epithelial Barrier via EC Angiocrine Signaling., PMID:38001832

Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks., PMID:37972575

An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation., PMID:37155852

MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis., PMID:36894989

Endometrial Heparin-Binding Epidermal Growth Factor Gene Expression and Hormone Level Changes in Implantation Window of Obese Women with Polycystic Ovarian Syndrome., PMID:36830813

Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages., PMID:36352257

Delivery of a peptide/microRNA blend via electrospun antimicrobial nanofibres for wound repair., PMID:36334906

In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19., PMID:35718334

HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog., PMID:35281434

Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma., PMID:34494649

Aloysia Citrodora Essential Oil Inhibits Melanoma Cell Growth and Migration by Targeting HB-EGF-EGFR Signaling., PMID:34360915

Optimizing the Expression and Solubilization of an E. coli-Produced Leukemia Inhibitory Factor for Anti-LIF Antibody Production and Use Thereof for Contraception in Mice., PMID:34272681

Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy., PMID:34135081

MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB-EGF/EGFR pathway., PMID:34028973

CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis., PMID:33973871

CITED4 enhances the metastatic potential of lung adenocarcinoma., PMID:33759374

Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling., PMID:33436543

SANT, a novel Chinese herbal monomer combination, decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer., PMID:33011366

MiR-183 impeded embryo implantation by regulating Hbegf and Lamc1 in mouse uterus., PMID:32980684

Contraceptive and molecular function of a novel recombinant vaccine based human leukemia inhibitory factor on Balb/c mice: An experimental in vivo study., PMID:32927320

Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing., PMID:32866426

Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR., PMID:32569674

Design and evaluation of a novel nanodrug delivery system for reducing the side effects of clomiphene citrate on endometrium., PMID:32483681

Sulfated glycolipid PG545 induces endoplasmic reticulum stress and augments autophagic flux by enhancing anticancer chemotherapy efficacy in endometrial cancer., PMID:32360360

SOX2 Promotes Brain Metastasis of Breast Cancer by Upregulating the Expression of FSCN1 and HBEGF., PMID:32322668

A novel exopolysaccharide from marine bacterium Pantoea sp. YU16-S3 accelerates cutaneous wound healing through Wnt/β-catenin pathway., PMID:32299547

s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide., PMID:32296111

HB-EGF-EGFR Signaling in Bone Marrow Endothelial Cells Mediates Angiogenesis Associated with Multiple Myeloma., PMID:31936715

HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats., PMID:31882563

HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation., PMID:31878047

Estrogen deficiency induces memory loss via altered hippocampal HB-EGF and autophagy., PMID:31648182

CRM197 reverses paclitaxel resistance by inhibiting the NAC-1/Gadd45 pathway in paclitaxel-resistant ovarian cancer cells., PMID:31490008

Dissecting cell diversity and connectivity in skeletal muscle for myogenesis., PMID:31160550

HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis., PMID:31127030

Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis., PMID:31125624

Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation., PMID:31033049

[Role and mechanism of the regulation of nuclear factor-κB by heparin binding-epidermal growth factor-like growth factor in the induction of paclitaxel resistance of ovarian cancer]., PMID:31006192

Discovery of HB-EGF binding peptides and their functional characterization in ovarian cancer cell lines., PMID:30937184

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