InVivoMAb Anti-Human FGF21 (Iv0067)

Catalog No.

VHJ67201

Species reactivity

Human

Host species

Human

Isotype

IgG

Clonality

Monoclonal

Target

FGF21, Fibroblast growth factor 21, FGF-21

Concentration

1.3 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NSA1

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0067

Chronic exposure to palmitic acid-induced adipocyte hypertrophy and altered batokine gene expression in T37i brown adipocytes., PMID:40449640

FGF-21 fusion proteins ameliorate atopic dermatitis by inhibiting the TLR/TSLP signaling pathway: Anti-inflammatory and skin barrier repair effects., PMID:40424659

Combination of Berberine and Evodiamine Alleviates Obesity by Promoting Browning in 3T3-L1 Cells and High-Fat Diet-Induced Mice., PMID:40362407

TSG attenuated NAFLD and facilitated weight loss in HFD-fed mice via activating the RUNX1/FGF21 signaling axis., PMID:40307458

MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes., PMID:40258148

Stimuli-responsive hydrogel with spatiotemporal co-delivery of FGF21 and H₂S for synergistic diabetic wound repair., PMID:40252979

Research progress and strategy of FGF21 for skin wound healing., PMID:40231082

A Novel Recombinant Human FGF21 Analog with High Glycosylation Has a Prolonged Half-Life and Affects Glycemic and Body Weight Control., PMID:40141314

Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631

γ-Oryzanol: A nutrient-rich ingredient for promoting wound healing., PMID:40028612

Aerobic Exercise Activates Fibroblast Growth Factor 21 and Alleviates Cardiac Ischemia/Reperfusion-induced Neuronal Oxidative Stress and Ferroptosis in Paraventricular Nucleus., PMID:40009261

FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis., PMID:39871339

Synergistic effect of canine FGF-21 combined with insulin in the treatment of canine diabetes., PMID:39836254

METTL14 knockdown attenuates neuron injury and improves function recovery after spinal cord injury via regulating FGF21 in a m6A-IGF2BP1 dependent mechanism., PMID:39821864

Fibroblast growth factor 21 alleviated atopic march by inhibiting the differentiation of type 2 helper T cells., PMID:39798471

AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse., PMID:39736351

Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro., PMID:39700773

Construction and Expression of Fc-FGF21 by Different Expression Systems and Comparison of Their Similarity and Difference with Efruxifermin by In Vitro and In Vivo Studies., PMID:39699797

Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis., PMID:39580762

Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice., PMID:39567986

Lipidation-dimerization platform unlocks treatment potential of fibroblast growth factor 21 for non-alcoholic steatohepatitis., PMID:39510256

FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway., PMID:39485628

Bictegravir alters glucose tolerance in vivo and causes hepatic mitochondrial dysfunction., PMID:39413881

Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock., PMID:39412985

FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury., PMID:39376607

TGF-β2, EGF and FGF21 influence the suckling rat intestinal maturation., PMID:39374742

Fibroblast growth factor 21 attenuates pulmonary ischemia/reperfusion injury via inhibiting endoplasmic reticulum stress-induced ferroptosis though FGFR1/PPARδ signaling pathway., PMID:39366074

Exploring the Wound Healing Potential of Hispidin., PMID:39339761

Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation., PMID:39268842

Ketogenic diet with aerobic exercise can induce fat browning: potential roles of β-hydroxybutyrate., PMID:39267855

The hepatokine FGF21 stopped lipogenesis and reduced testosterone production in mLTC-1 Leydig Cell Line., PMID:39233040

Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis., PMID:39226764

Fusion protein of FGF21 and elastin-like peptide improves wound healing in diabetic mice via inflammation modulation, collagen synthesis, and vascular network formation., PMID:39216743

Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: In vivo and liver organoids-based in vitro study., PMID:39213921

PF-05231023 reduces lipid deposition in apolipoprotein E-deficient mice by inhibiting the expression of lipid synthesis genes., PMID:39144082

MVP enhances FGF21-induced ferroptosis in hepatocellular carcinoma by increasing lipid peroxidation through regulation of NOX4., PMID:39143889

Biohybrid hydrogel inhibiting β-klotho/HDAC3 axis for hepatocellular carcinoma treatment., PMID:39098678

Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity., PMID:39019110

A novel fatty acid mimetic with pan-PPAR partial agonist activity inhibits diet-induced obesity and metabolic dysfunction-associated steatotic liver disease., PMID:38763495

Enhanced bioactivity and stability of a long-acting FGF21: A novel variant for the treatment of NASH., PMID:38740172

Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise., PMID:38682314

Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production., PMID:38673797

Ultrasound‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction., PMID:38666537

The dual GCGR/GLP-1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection., PMID:38560764

BV2 Membrane-Coated PEGylated-Liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy., PMID:38513154

Fibroblast growth factor 21 mitigates lupus nephritis progression via the FGF21/Irgm 1/NLRP3 inflammasome pathway., PMID:38508095

In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors., PMID:38409275

Docosahexaenoic and Eicosapentaenoic Acids Promote the Accumulation of Browning-Related Myokines via Calcium Signaling in Insulin-Resistant Mice., PMID:38367811

Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21., PMID:38316771

Mitochondrial complex I inhibition triggers NAD+-independent glucose oxidation via successive NADPH formation, "futile" fatty acid cycling, and FADH2 oxidation., PMID:38267672

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