InVivoMAb Anti-Human IGF2 (Iv0064)

Catalog No.

VHB94101

Species reactivity

Human

Host species

Human

Isotype

IgG2

Clonality

Monoclonal

Target

IGF2, IGF-II, Insulin-like growth factor II, T3M-11-derived growth factor, Somatomedin-A

Concentration

1.34 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01344

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0064

Reduced NF-κB/NLRP3/IL-18 signaling increases the protective effect of L-glutamine against LPS-induced retinal inflammation in mice: Utilization of network pharmacology and experimental validation., PMID:40513937

POU6F2 promotes liver metastasis of gastric adenocarcinoma by dual mechanism of transcriptional upregulation of SNAI1 and IGF2/PI3K/AKT signaling-induced conversion of hepatic stellate cells into cancer-associated fibroblasts., PMID:40301686

Synergistic effects of curcumin and piperine in cocrystal form: a breakthrough in bladder cancer therapy., PMID:40270345

IGF2-Reprogrammed Macrophages Ameliorate the Inflammatory Response and Protect Against the Neuroinflammatory Process in Parkinson's Disease Models., PMID:40146621

Insulin-Like Growth Factor 2 Secreted from Mesenchymal Stem Cells with High Glutathione Levels Alleviates Osteoarthritis via Paracrine Rejuvenation of Senescent Chondrocytes., PMID:39990979

Engineering IGF2 for Lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy., PMID:39969096

Spectrum and carcinogenic properties of thyroglobulin gene fusions in thyroid., PMID:39878559

Aluminum Induces Neurotoxicity through the MicroRNA-98-5p/Insulin-like Growth Factor 2 Axis., PMID:39804702

Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma., PMID:39799319

IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A-Mediated NLRP3 Inflammasome., PMID:39783247

Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice., PMID:39370505

Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus., PMID:39334352

Replacing sperm with genotyped haploid androgenetic blastomeres to generate cattle with predetermined paternal genomes†., PMID:39303105

Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice., PMID:39283743

Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors., PMID:39171181

Immunomodulatory effects of the induced pluripotent stem cells through expressing IGF-related factors and IL-10 in vitro., PMID:39162714

Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis., PMID:38886900

Targeting IGF2 to reprogram the tumor microenvironment for enhanced viro-immunotherapy., PMID:38853689

Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso., PMID:38840164

BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice., PMID:38678558

circ-TFRC downregulation suppresses ovarian cancer progression via miR-615-3p/IGF2 axis regulation., PMID:38678242

Lithium chloride promotes mesenchymal-epithelial transition in murine cutaneous wound healing via inhibiting CXCL9 and IGF2., PMID:38610097

Pleomorphic adenoma gene1 in reproduction and implication for embryonic survival in cattle: a review., PMID:38586898

IGF2 promotes alveolar bone regeneration in murine periodontitis via inhibiting cGAS/STING-mediated M1 macrophage polarization., PMID:38565043

Regulation of trophic factors in the choroid plexus of aged mice., PMID:38562722

A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia., PMID:38555405

Targeting G9a/DNMT1 methyltransferase activity impedes IGF2-mediated survival in hepatoblastoma., PMID:38285887

Inhibiting the m6A Reader IGF2BP3 Suppresses Ovarian Cancer Cell Growth via Regulating PLAGL2 mRNA Stabilization., PMID:38274714

Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke., PMID:38178130

IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B., PMID:38081361

IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models., PMID:38042807

IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in D-galactose-induced aging mice., PMID:38017373

Cysteamine improves growth and the GH/IGF axis in gilthead sea bream (Sparus aurata): in vivo and in vitro approaches., PMID:37547324

Human-relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice., PMID:37439711

Impact of Chorionic Somatomammotropin In Vivo RNA Interference Phenotype on Uteroplacental Expression of the IGF Axis., PMID:37374044

Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes., PMID:37347736

Brushite-coated Mg-Nd-Zn-Zr alloy promotes the osteogenesis of vertebral laminae through IGF2/PI3K/AKT signaling pathway., PMID:37327764

Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway., PMID:37206078

Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome., PMID:37170172

Human relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice., PMID:36993736

Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells., PMID:36822301

Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability., PMID:36809604

IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells., PMID:36633189

Exosomes from cisplatin-induced dormant cancer cells facilitate the formation of premetastatic niche in bone marrow through activating glycolysis of BMSCs., PMID:36568212

Genetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female mice., PMID:36459047

Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways., PMID:36373776

miR-196a enhances polymerization of neuronal microfilaments through suppressing IMP3 and upregulating IGF2 in Huntington's disease., PMID:36320323

Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization., PMID:36302455

SP1-induced lncRNA MCF2L-AS1 promotes cisplatin resistance in ovarian cancer by regulating IGF2BP1/IGF2/MEK/ERK axis., PMID:36245227

Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage., PMID:36109564

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