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InVivoMAb Anti-Human GDF2/BMP9 (Iv0060)

Catalog #:   VHJ78401 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: ELISA, Neutralization
Accession: Q9UK05
Overview

Catalog No.

VHJ78401

Species reactivity

Human

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

GDF2, BMP-9, Growth/differentiation factor 2, Bone morphogenetic protein 9, GDF-2, BMP9

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9UK05

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0060

Data Image
References

Thermoresponsive dual-network chitosan-based hydrogels with demineralized bone matrix for controlled release of rhBMP9 in the treatment of femoral head osteonecrosis., PMID:39843099

Hypoxia-induced TIMAP upregulation in endothelial cells and TIMAP-dependent tumor angiogenesis., PMID:39344413

DDIT3 switches osteogenic potential of BMP9 to lipogenic by attenuating Wnt/β-catenin signaling via up-regulating DKK1 in mesenchymal stem cells., PMID:39331002

Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells., PMID:38031108

Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module., PMID:37972658

BMP-9 Improves the Osteogenic Differentiation Ability over BMP-2 through p53 Signaling In Vitro in Human Periosteum-Derived Cells., PMID:37894931

Induced regeneration of articular cartilage - identification of a dormant regeneration program for a non-regenerative tissue., PMID:37882667

MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts., PMID:37802385

BMP9 functions as a negative regulator in the myogenic differentiation of primary mouse myoblasts., PMID:37553201

TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9., PMID:36575168

Comparison of the biomechanical differences in the occlusal movement of wild-type and BMP9 knockout mice with apical periodontitis., PMID:36324890

BMP9-ID1 Signaling Activates HIF-1α and VEGFA Expression to Promote Tumor Angiogenesis in Hepatocellular Carcinoma., PMID:35163396

Bone morphogenic protein 9 is a novel thermogenic hepatokine secreted in response to cold exposure., PMID:35063533

Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine., PMID:35005773

Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway., PMID:34837694

Overexpression of BMP9 promotes ovarian cancer progression via Notch1 signaling., PMID:34533030

High-throughput measurements of bone morphogenetic protein/bone morphogenetic protein receptor interactions using biolayer interferometry., PMID:34241280

BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma., PMID:33834612

BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization., PMID:33812253

Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells., PMID:33660290

BMP9-initiated osteogenic/odontogenic differentiation of mouse tooth germ mesenchymal cells (TGMCS) requires Wnt/β-catenin signalling activity., PMID:33605035

BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State., PMID:33334130

Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor-β Signaling in Human Endothelial Cells., PMID:33168642

TGFβ1 induces bone formation from BMP9-activated Bone Mesenchymal Stem Cells, with possible involvement of non-canonical pathways., PMID:32714072

BMP9 exhibits dual and coupled roles in inducing osteogenic and angiogenic differentiation of mesenchymal stem cells., PMID:32478395

Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms., PMID:32238803

Differential Responsiveness to BMP9 between Patent and Fused Suture Progenitor Cells from Craniosynostosis Patients., PMID:32097313

The wonders of BMP9: From mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine., PMID:32042861

Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling., PMID:32041483

BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling., PMID:31914211

Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models., PMID:31689244

Role of bone morphogenetic protein-9 in the regulation of glucose and lipid metabolism., PMID:31237775

BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells., PMID:30353129

BMP9 inhibits the growth of breast cancer cells by downregulation of the PI3K/Akt signaling pathway., PMID:30015950

A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma., PMID:29789425

BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1., PMID:29642505

Hmox1 promotes osteogenic differentiation at the expense of reduced adipogenic differentiation induced by BMP9 in C3H10T1/2 cells., PMID:29377252

Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202

RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells., PMID:29039519

BMP9 induces osteogenesis and adipogenesis in the immortalized human cranial suture progenitors from the patent sutures of craniosynostosis patients., PMID:28470873

Gelatin-Derived Graphene-Silicate Hybrid Materials Are Biocompatible and Synergistically Promote BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells., PMID:28406027

Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)., PMID:28384643

Repair of critical sized cranial defects with BMP9-transduced calvarial cells delivered in a thermoresponsive scaffold., PMID:28249039

Bone morphogenetic protein 9 facilitates osteocarcinoma cell apoptosis and inhibits in vivo tumor growth., PMID:27706722

A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells., PMID:27097687

BMP9/p38 MAPK is essential for the antiproliferative effect of resveratrol on human colon cancer., PMID:26555012

DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1., PMID:26471266

A simplified and versatile system for the simultaneous expression of multiple siRNAs in mammalian cells using Gibson DNA Assembly., PMID:25398142

Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis., PMID:25237187

BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways., PMID:24805814

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

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For research use only. Not for human or drug use.

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InVivoMAb Anti-Human GDF2/BMP9 (Iv0060) [VHJ78401]
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