InVivoMAb Anti-Human Flt3 ligand/FLT3LG (Iv0057)

Catalog No.

VHE70701

Species reactivity

Human

Host species

Human

Isotype

IgG1, lambda

Clonality

Monoclonal

Target

SL cytokine, FLT3LG, Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L

Concentration

3.1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P49771

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0057

FLT3 ligand regulates expansion of regulatory T-cells induced by regulatory dendritic cells isolated from gut-associated lymphoid tissues through the Notch pathway., PMID:40211734

Dectin-1-Dependent Activation of Flt3 Ligand-Induced Dendritic Cells by the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body., PMID:40100228

Human dendritic cell differentiation in hematopoietic stem cell-transplanted NOG hFLT3L Tg/mFlt3 KO humanized mice., PMID:39536946

Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation., PMID:38608038

FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors., PMID:38287325

Antigen-loaded Monocyte Administration and Flt3 Ligand Augment the Antitumor Efficacy of Immune Checkpoint Blockade in a Murine Melanoma Model., PMID:37737688

Enrichment of Large Numbers of Splenic Mouse Dendritic Cells After Injection of Flt3L-Producing Tumor Cells., PMID:36905517

Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics., PMID:36440960

Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia., PMID:36005562

A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL., PMID:35288466

Single-cell RNA sequencing distinguishes dendritic cell subsets in the rat, allowing advanced characterization of the effects of FMS-like tyrosine kinase 3 ligand., PMID:35285040

Murine Dendritic Cells Grown in Serum-Free Culture Show Potent Therapeutic Activity when Loaded with Novel Th Epitopes in an Orthotopic Model of HER2pos Breast Cancer., PMID:34579275

Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma., PMID:34083417

The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo., PMID:33647585

Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets., PMID:35121932

Development of Pig Conventional Dendritic Cells From Bone Marrow Hematopoietic Cells in vitro., PMID:33162975

Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype., PMID:32917656

A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells., PMID:32848036

Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis., PMID:32453421

Engineered niches support the development of human dendritic cells in humanized mice., PMID:32345968

FLT3L and granulocyte macrophage colony-stimulating factor enhance the anti-tumor and immune effects of an HPV16 E6/E7 vaccine., PMID:31881013

FLT3/FLT3L-mediated CD103+ dendritic cells alleviates hepatic ischemia-reperfusion injury in mice via activation of treg cells., PMID:31545219

Synergistic effects of PRIMA-1Met (APR-246) and 5-azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia., PMID:31488557

A Recombinant Rabies Virus Expressing Fms-like Tyrosine Kinase 3 Ligand (Flt3L) Induces Enhanced Immunogenicity in Mice., PMID:31254272

Short-, Mid-, and Long-Term Effect of Granulocyte Colony-Stimulating Factor/Stem Cell Factor and Fms-Related Tyrosine Kinase 3 Ligand Evaluated in an In Vivo Model of Hypoxic-Hyperoxic Ischemic Neonatal Brain Injury., PMID:31001556

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination., PMID:30962585

In vitro and in vivo evaluation of possible pro-survival activities of PGE2, EGF, TPO and FLT3L on human hematopoiesis., PMID:30442724

Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand., PMID:30364182

Fms-Like Tyrosine Kinase 3-Ligand Contributes to the Development and Function of the Subpopulation of CD8α+ Plasmacytoid Precursor Dendritic Cells in CD8+ /TCR- Facilitating Cells., PMID:30004616

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells., PMID:29925006

Bone marrow-derived inflammatory and steady state DCs are different in both functions and survival., PMID:29909072

Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3+CD4+ T Cells., PMID:29892279

IL1RAP potentiates multiple oncogenic signaling pathways in AML., PMID:29773641

A new cancer immunotherapy via simultaneous DC-mobilization and DC-targeted IDO gene silencing using an immune-stimulatory nanosystem., PMID:29752722

Targeting FLT3 in acute myeloid leukemia using ligand-based chimeric antigen receptor-engineered T cells., PMID:29716633

Metabolic control of cell fate bifurcations in a hematopoietic progenitor population., PMID:29570858

Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo., PMID:29317685

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells., PMID:29240787

Study of stem cell homing & self-renewal marker gene profile of ex vivo expanded human CD34+ cells manipulated with a mixture of cytokines & stromal cell-derived factor 1., PMID:29168461

Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments., PMID:29106601

Listeria monocytogenes Replicate in Bone Marrow-Derived CD11c+ Cells but Not in Dendritic Cells Isolated from the Murine Gastrointestinal Tract., PMID:29055001

Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo., PMID:28968180

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12., PMID:28729715

The angiogenic factor Egfl7 alters thymogenesis by activating Flt3 signaling., PMID:28601636

Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells., PMID:28228109

NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia., PMID:27863389

CD103+ CD11b- salivary gland dendritic cells have antigen cross-presenting capacity., PMID:27861804

Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo., PMID:27798171

Murine Flt3 ligand-generated plasmacytoid and conventional dendritic cells display functional differentiation in activation, inflammation, and antigen presentation during BCG infection in vitro., PMID:27496194

Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells., PMID:27331411

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