Catalog No.
FHJ93310
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
p28, Interleukin-27 subunit alpha, IL-27 subunit alpha, IL27A, IL27, IL-27-A, Interleukin-30, IL30, IL27-A, IL-27B, Interleukin-27 subunit beta, EBI3, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, IL27B, IL-27 subunit beta
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8NEV9 & Q14213
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0393
Serum Levels of IL-21 and IL-27 Do not Reflect differential Avidity of Anti-SARS-CoV-2 IgG Antibodies in Symptomatic and Asymptomatic COVID-19 Patients., PMID:40471646
Publisher Correction: ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27., PMID:40404637
ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27., PMID:40281007
Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance., PMID:40276760
Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis., PMID:40234384
Factors influencing the development of osteoporosis in elderly patients with rheumatoid arthritis., PMID:40190502
Tigecycline modulates LPS-induced inflammatory response in sepsis via NF-κB signalling pathways: Experimental insights into immune regulation., PMID:40139445
IL-12 family cytokines and autoimmune diseases: A potential therapeutic target?, PMID:39759268
Antimalarial Drug Artemotil Promotes Induction of Type 1 Regulatory T Cells., PMID:39607628
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Interleukin-27 Regulates Adaptative Immune Responses Associated With Control of Parasite Replication in Canine Leishmaniasis., PMID:39360782
IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria., PMID:38394242
Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells., PMID:38376210
A cell-adapted SARS-CoV-2 mutant, showing a deletion in the spike protein spanning the furin cleavage site, has reduced virulence at the lung level in K18-hACE2 mice., PMID:38324940
Primary liver cancer spectrum: current knowledge and the next steps., PMID:38322221
Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis., PMID:38224627
Faslpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus., PMID:38113962
Study on the Treatment of ITP Mice with IVIG Sourced from Distinct Sex-Special Plasma (DSP-IVIG)., PMID:37958975
Mechanism of synergistic inhibitory effect of benzyl isothiocyanate and zoledronic acid combination on breast cancer induction of osteoclast differentiation., PMID:37921547
Immunomodulatory chitosan nanoparticles for Toxoplasma gondii infection: Novel application of chitosan in complex propranolol-hydrochloride as an adjuvant in vaccine delivery., PMID:37839605
Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27., PMID:37756334
Vasculitis Activity-Predicting Ability of IL-12 Family Cytokines in Patients with Microscopic Polyangiitis and Granulomatosis with Polyangiitis., PMID:37727919
Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23., PMID:37714687
IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection., PMID:37583704
IL-27 enhances peripheral B cell glycolysis of rheumatoid arthritis patients via activating mTOR signaling., PMID:37354782
Evaluation of acellular pertussis vaccine: comparisons among different strains of mice., PMID:36930702
Cytokine receptor IL27RA is an NF-κB-responsive gene involved in CD38 upregulation in multiple myeloma., PMID:36867577
Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation., PMID:36653124
IL-17D affects the chemokines and chemokine receptors of intestinal epithelial cells under hyperoxia., PMID:36461593
Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients., PMID:36406863
Interleukin-27 Ameliorates Atherosclerosis in ApoE-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance., PMID:36405994
Integrated Analysis of Cytokine Profiles in Malaria Patients Discloses Selective Upregulation of TGF-β1, β3, and IL-9 in Mild Clinical Presentation., PMID:36293524
Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27., PMID:36261006
Relationship between cerebrospinal fluid biomarkers of inflammation and tissue damage in primary progressive multiple sclerosis., PMID:36257152
Analysis of gene expression profiles to study malaria vaccine dose efficacy and immune response modulation., PMID:36239109
Heterogenous CD8+ T Cell Maturation and 'Polarization' in Acute and Convalescent COVID-19 Patients., PMID:36146713
Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study., PMID:35875815
4-1BB antibody enhances cytotoxic activity of natural killer cells against prostate cancer cells via NKG2D agonist combined with IL-27., PMID:35852136
Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers., PMID:35794623
Contribution of interleukin 27 serum level to pathogenesis and prognosis in children with immune thrombocytopenia., PMID:35758390
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages., PMID:35728978
IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance., PMID:35695698
[Clinical efficacy and safety evaluation of acupuncture combined with moxibustion in treatment of allergic rhinitis]., PMID:35486013
IL-27 promotes decidualization via the STAT3-ESR/PGR regulatory axis., PMID:35430461
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine., PMID:35132413
Intermediate monocytes induced by IFN-γ inhibit cancer metastasis by promoting NK cell activation through FOXO1 and interleukin-27., PMID:35091454
The association of IL-3, IL-17A, and IL 27 serum levels with susceptibility to toxoplasmosis in recurrent abortion of Iraqi women., PMID:35085575
IL-27 signaling negatively regulates FcɛRI-mediated mast cell activation and allergic response., PMID:35075687
B cell-derived IL-27 promotes control of persistent LCMV infection., PMID:35022243
Lack of Association between Serum Interleukin-23 and Interleukin-27 Levels and Disease Activity in Patients with Active Systemic Lupus Erythematosus., PMID:34682911
For research use only. Not for human or drug use.
