Catalog No.
FHD84010
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, lambda
Clonality
Monoclonal
Conjugation
Unconjugated
Target
IL-12 subunit p40, IL12B, Interleukin-12 subunit beta, IL-12B, CLMF p40, NKSF2, NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29460
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0381
High-affinity nanobodies targeting IL-12B for the detection of fluorescence resonance energy transfer., PMID:39921134
IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not γδT 17 cells, in TAC mice., PMID:38677538
Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature., PMID:34389021
Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn's Disease., PMID:32679193
Anti-IL-12/23 p40 antibody attenuates chronic graft-versus-host disease with lupus nephritis via inhibiting Tfh cell in mice., PMID:32580046
Specific single nucleotide polymorphism genotypes and association of an IL-12B polymorphism with secondary failure of infliximab therapy in Japanese psoriasis patients., PMID:32576423
Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin-1β., PMID:31478196
IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans., PMID:31470035
In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine., PMID:31131048
The analysis of the therapeutic potential of ustekinumab in psoriasis vulgaris treatment., PMID:30693647
Severe disseminated Nocardia infection associated with ustekinumab treatment for psoriasis., PMID:30657168
Case of pityriasis rubra pilaris progressed to generalized erythroderma following blockade of interleukin-17A, but improved after blockade of interleukin-12/23 p40., PMID:30506728
Interferon-γ-dependent protection against Neospora caninum infection conferred by mucosal immunization in IL-12/IL-23 p40-deficient mice., PMID:30037479
Genetic modifications of cytokine genes and Toxoplasma gondii infections in pregnant women., PMID:29859292
Allergic and Immunologic Perspectives of Inflammatory Bowel Disease., PMID:29754190
Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells., PMID:29467328
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1., PMID:29287995
Genetic Susceptibility in Family Members of Egyptian Hepatitis C Virus Infected Patients: Role of Interleukin-12 B Gene Polymorphism., PMID:29283074
The genetics of Takayasu arteritis., PMID:28756073
Effects of interleukin-4 and interleukin-12B gene polymorphisms on hepatitis B virus vaccination., PMID:28051794
IL-12/IL-23p40 Is Highly Expressed in Secondary Lymphoid Organs and the CNS during All Stages of EAE, but Its Deletion Does Not Affect Disease Perpetuation., PMID:27780253
Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis., PMID:27564082
Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins., PMID:27402834
Influenza Virus Hemagglutinin Glycoproteins with Different N-Glycan Patterns Activate Dendritic Cells In Vitro., PMID:27099319
Interleukin‑12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts., PMID:26956410
IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis., PMID:26678060
Contribution of IL-12A and IL-12B polymorphisms to Chlamydia trachomatis-specific cell-mediated immune responses., PMID:25565213
IL-10, IL-12B and IL-17 gene polymorphisms in patients with mixed connective tissue disease., PMID:25159155
Association of the interleukin-12 polymorphic variants with the development of antibodies to surface antigen of hepatitis B virus in hemodialysis patients in response to vaccination or infection., PMID:24158609
Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models., PMID:23716000
Therapeutic strategies in psoriasis patients with psoriatic arthritis: focus on new agents., PMID:23580094
Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment., PMID:23468464
Anti-IFN-γ autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection., PMID:23243276
IL-20, IL-21 and p40: potential biomarkers of treatment response for ustekinumab., PMID:22930279
No association between IL12B gene polymorphisms and Graves' disease in the Chinese population., PMID:22621617
Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease., PMID:22275320
Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin., PMID:21352568
The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype., PMID:21198744
Genetic variations associated with psoriasis and psoriatic arthritis found by genome-wide association., PMID:20415816
[Enlightenment from genome-wide association study to genetics of psoriasis]., PMID:19693967
Ustekinumab., PMID:19344192
Relationship between the IL-12B promoter polymorphism and allergic rhinitis, familial asthma, serum total IgE, and eosinophil level in asthma patients., PMID:19274925
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes., PMID:17236132
Polymorphisms in the IL-12B gene and outcome of HCV infection., PMID:15871664
Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains., PMID:12070779
For research use only. Not for human or drug use.
