Catalog No.
VHG70701
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
IFN-gamma-inducing factor, IL1F4, Interleukin-1 gamma, IL-18, IL-1 gamma, Interleukin-18, Interferon gamma-inducing factor, IGIF, IL18, Iboctadekin
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14116
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0030
Reduced NF-κB/NLRP3/IL-18 signaling increases the protective effect of L-glutamine against LPS-induced retinal inflammation in mice: Utilization of network pharmacology and experimental validation., PMID:40513937
MicroRNAs as regulators of NLRP3 inflammasome activation in herpes simplex virus type 2 infection., PMID:40510795
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling., PMID:40490166
Rutin Protects Myocardial Ischemia-Reperfusion Injury via the NF-κB/NLRP3/Pyroptosis Pathway., PMID:40488073
Inhibiting NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis: A New Role of GADD45B's Role in Hypertriglyceridemia-Induced Acute Pancreatitis., PMID:40485526
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells., PMID:40483833
Therapeutic potential of inosine in acute lung injury: mechanistic insights into TLR4 suppression and macrophage polarization., PMID:40479887
[Polysaccharide extract PCP1 from Polygonatum cyrtonema ameliorates cerebral ischemia-reperfusion injury in rats by inhibiting TLR4/NLRP3 pathway]., PMID:40461201
Integrating serum pharmacochemistry and metabolomics to reveal the potential effective ingredients and mechanism of Huangqi Chifeng Tang intervening carotid atherosclerosis., PMID:40456475
Matrix-bound EGF promotes malignant phenotypes of breast cancer organoids in the biomimetic ECM of alginate., PMID:40453816
Protective effect of a novel nonsteroidal organoselenium compound SLL-1-43 on ulcerative colitis through down-regulating NOX2 signaling pathway in vitro and in vivo., PMID:40450981
XBP1 Knockdown Alleviates Pyroptosis and Promotes Th17/Treg Imbalance in Periodontitis by Inhibiting the IL-17 Signaling Pathway., PMID:40447963
Shikonin inhibits NLRP3 inflammasome activation and controls inflammatory disease., PMID:40447675
Sevoflurane induces cognitive dysfunction by modulating PER2 methylation to block AKT pathway-suppressed NLRP3 inflammatory vesicle in microglia., PMID:40440547
Naringenin inhibits PRV replication by regulating the TLR4/NF-κB pathway mediated inflammatory response., PMID:40435750
Multitargeted Effects of Plantago ovata Ethanol Extract in Experimental Rat Streptozotocin-Induced Diabetes Mellitus and Letrozole-Induced Polycystic Ovary Syndrome., PMID:40429855
Therapeutic Potential of Lythrum salicaria L. Ethanol Extract in Experimental Rat Models of Streptozotocin-Induced Diabetes Mellitus and Letrozole-Induced Polycystic Ovary Syndrome., PMID:40427455
Lingguizhugan decoction ameliorates renal injury secondary to heart failure by improving pyroptosis through TLR4/NF-KB/IRE1α pathway., PMID:40424980
CEBPD is a pivotal factor for the activation of NLRP3 inflammasome in traumatic brain injury., PMID:40414072
Saw Palmetto Extract Ameliorates Benign Prostatic Hyperplasia by Regulating 5α-Reductase and Apoptosis In Vitro and In Vivo., PMID:40395126
BAM15 inhibits endothelial pyroptosis via the NLRP3/ASC/caspase-1 pathway to alleviate atherosclerosis., PMID:40393254
NLRP3 inflammasome activation by turbulent shear stress drives right ventricular outflow tract fibrosis in pulmonary regurgitation., PMID:40384971
Shen Shuai II Recipe alleviates renal fibrosis in chronic kidney disease by improving of hypoxia and inhibition of TLR4/MyD88/NF-κB/NLRP3 pathway., PMID:40384385
Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation., PMID:40375539
Ginsenoside Rg2 Alleviates HFD/STZ-Induced Diabetic Nephropathy by Inhibiting Pyroptosis via NF-κB/NLRP3 Signaling Pathways., PMID:40374378
Computational drug discovery of phytochemical alkaloids targeting the NACHT/PYD domain in the NLRP3 inflammasome., PMID:40368915
GATA1-mediated Notch signaling augment antitumor immunity of CD11b+CD27- natural killer cells maturation via BCL9/β-catenin signal., PMID:40366806
Spironolactone protects against hypertension-induced renal fibrosis by promoting autophagy and inhibiting the NLRP3 inflammasome., PMID:40366120
Modeling the HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death., PMID:40359482
Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease., PMID:40355878
Degradation of WE43 Magnesium Alloy in Vivo and Its Degradation Products on Macrophages., PMID:40352546
TLR2 promotes the progression of diabetes mellitus with atherosclerosis via activating NLRP3 inflammasome and MyD88/NF-κB signaling pathway., PMID:40348852
PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB-p65/NLRP3 pathway., PMID:40343297
Intracellular bacterial LPS drives pyroptosis and promotes aggressive phenotype in oral squamous cell carcinoma., PMID:40338411
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway., PMID:40337514
MSCs in Acute Kidney Injury Treatment: Modulating Mitochondrial Function and Inhibiting Pyroptosis via PGC-1α., PMID:40324626
Study on the correlation between Flavobacterium columnare infection and gill injury in Largemouth bass (Micropterus salmoides) and the protective effect of Enoxolone., PMID:40318709
Salt-induced vascular damage in hypertension involves redox activation of PARP/TRPM2 signalling and inflammasome assembly., PMID:40312994
PLGA-Encapsulated Elvitegravir and Curcumin Modulates ART Penetration, Oxidative Stress, and Inflammation., PMID:40309788
Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis., PMID:40307659
Study on the mechanism of action of Penehyclidine hydrochloride on LPS-induced acute lung injury by regulating autophagy through the mTOR/Keap1/Nrf2 signaling pathway., PMID:40306137
Colchicine inhibits myocardial pyroptosis and reduces myocardial cell injury after myocardial infarction through the ESR1-PI3K-Akt-NF-κB signaling pathway., PMID:40294468
The Extract of Siegesbeckia orientalis L. Reverses Pro-inflammatory Status of Microglia for Neuroprotection Following Ischemic Stroke in Mice., PMID:40289983
The Phytochemical and Functional Characterization of the Aerial Parts of Artemisa alba Turra (Asteraceae) Grown in Romania., PMID:40282790
Targeting ceramide-induced microglial pyroptosis: Icariin is a promising therapy for Alzheimer's disease., PMID:40256246
Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease., PMID:40242753
Treg Cells Attenuate Pulmonary Venous Remodeling in PH-LHD via NLRC3 Signaling., PMID:40235449
Mechanical stress overload promotes NF-κB/NLRP3-mediated osteoarthritis synovitis and fibrosis through Piezo1., PMID:40221068
Flowers and Leaves of Artemisia absinthium and Artemisia annua Phytochemical Characterization, Anti-Inflammatory, Antioxidant, and Anti-Proliferative Activities Evaluation., PMID:40219097
Anthocyanin-Rich Fraction from Kum Akha Black Rice Attenuates NLRP3 Inflammasome-Driven Lung Inflammation In Vitro and In Vivo., PMID:40218944
For research use only. Not for human or drug use.
