Catalog No.
VHD84001
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
IL-12 subunit p40, IL12B, Interleukin-12 subunit beta, IL-12B, CLMF p40, NKSF2, NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29460
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0026
Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment., PMID:36855120
MEF2C promotes M1 macrophage polarization and Th1 responses., PMID:35194174
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo., PMID:34644571
Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice., PMID:33452873
Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn's Disease., PMID:32679193
Polymeric Nanoparticles that Combine Dexamethasone and Naproxen for the Synergistic Inhibition of Il12b Transcription in Macrophages., PMID:32421256
Ibudilast Inhibits Chemokine Expression in Rheumatoid Arthritis Synovial Fibroblasts and Exhibits Immunomodulatory Activity in Experimental Arthritis., PMID:30474934
Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue., PMID:28870465
Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response., PMID:28739930
Evaluation of IL-12RB1, IL-12B, CXCR-3 and IL-17a expression in cases affected by a non-healing form of cutaneous leishmaniasis: an observational study design., PMID:28132002
Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination., PMID:26621525
Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis., PMID:24634494
Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models., PMID:23716000
Levels of interleukin-(IL)-12p40 are markedly increased in Brucellosis among patients with specific IL-12B genotypes., PMID:23578145
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production., PMID:23297419
IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis., PMID:22786766
Interleukin-12: clinical usage and molecular markers of cancer susceptibility., PMID:22515181
NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity., PMID:21383239
Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene., PMID:19134014
Porcine IL12A and IL12B gene mapping, variation and evidence of association with lytic complement and blood leucocyte proliferation traits., PMID:18186802
Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo., PMID:17675497
IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation., PMID:14978093
IL-12: the role of p40 versus p75., PMID:12100467
For research use only. Not for human or drug use.
