Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis., PMID:40513868
Effects of intracerebroventricular lipopolysaccharide administration on behavioral, neurochemical, and neurogenomic responses in adult zebrafish., PMID:40466776
LOXL2 Deletion Triggers TMJ Osteoarthritis While Overexpression Protects Against NF-κβ-Induced Chondrocyte Apoptosis., PMID:40463059
Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation., PMID:40453664
Oral roflumilast suppresses pro-inflammatory cytokine signaling and reduces CD4+ T cell and neutrophil infiltration in psoriasis., PMID:40403838
Disruption of the caspase-1/IL-1β axis alleviates myocardial Ischemia/Reperfusion injury via improvement of mitochondrial homeostasis and reduction of Pyroptosis., PMID:40373207
Gan-tang-yi decoction improves hepatic insulin resistance through activation of IRS2/PI3K/Akt pathway and inhibition of AGEs/RAGE pathway in cirrhotic rats., PMID:40345270
GPR40 inhibits microglia-mediated neuroinflammation via the NLRP3/IL-1β/glutaminase pathway after subarachnoid hemorrhage., PMID:40318813
G-CSF-Induced Emergency Granulopoiesis Modulates Neutrophil Effector Function in Mice., PMID:40299198
Topical loratadine-loaded invasomal gel repurposed for vulvovaginal candidiasis; in vitro, in silico, ex vivo, and in vivo studies., PMID:40287073
S100A8/A9 high-expression macrophages mediate renal tubular epithelial cell damage in acute kidney injury following acute type A aortic dissection surgery., PMID:40270593
PTGS2 Silencing Inhibits Ferroptosis in Staphylococcus Aureus-induced Osteomyelitis By Blocking the IL-17A Signaling Pathway., PMID:40257651
Liposomic lubricants suppress acute inflammatory gene regulation in the joint in vivo., PMID:40220945
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice., PMID:40216265
Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation., PMID:40215175
Hypolipidemic effect and mechanism of Hedan tablet based on network pharmacology., PMID:40151127
SOAT1 Activates NLRP3 Inflammasome to Promote Cancer-Related Lymphangiogenesis and Metastasis via IL-1β/IL-1R-1 Axis in Oral Squamous Cell Carcinoma., PMID:40135589
A novel synthetic oxazolidinone derivative BS-153 attenuated LPS-induced inflammation via inhibiting NF-κB/pkcθ signaling pathway., PMID:40122191
Immunomodulatory effects of Sanghuangporus flavonoids: Key insights into enhancing immunity and restoring immune function., PMID:40117809
Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease., PMID:40114310
The inhibitory effect of Astragalus flavone extract on hyperuricemia and its underlying molecular mechanism by targeting JNK/AP-1/NLRP3/IL-1β signaling pathway., PMID:40073779
AMD1, a cardiotoxicity target for Maduramicin., PMID:40069794
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway., PMID:40056656
Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation., PMID:40033067
Effects of Pesticide Exposure on Neuroinflammation and Microglial Gene Expression: Relevance to Mechanisms of Alzheimer's Disease Risk., PMID:40027678
Network pharmacology and experimental analysis of Yudantong decoction, a multi-immunomodulator for the treatment of intractable cholestatic liver disease: Identification of active agents, molecular targets, and mechanisms of action., PMID:40013962
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer., PMID:40010767
Kinsenoside alleviates experimental acute pancreatitis by suppressing M1 macrophage polarization via the TLR4/STAT1 signaling pathway., PMID:39999939
Evaluating Salidroside as a Therapeutic Agent for Vascular Calcification Using Network Pharmacology and Experimental Rat Models., PMID:39960197
The role of glutathione S-transferase mu 2 in mitigating fatty acid-induced hepatic inflammation in dairy cows., PMID:39947611
Network Pharmacology Analysis and Biological Validation Systemically Identified the Active Ingredients and Molecular Targets of Kudzu Root on Osteoporosis., PMID:39940967
Lysosomal Fe2+ influx through MCOLN1 channel prevents sustained inflammation by limiting PHDs-regulated NFKB activation in macrophages., PMID:39936589
N-acetyltransferase 10 regulates UNC-51-like kinase 1 to reduce tubular cell injury and kidney stone formation., PMID:39917001
β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy., PMID:39891248
Luteolin Mitigates Acute Lung Injury Through Immune Modulation and Antinecroptosis Effects by Targeting the BTK and FLT3 Signaling Pathways., PMID:39885663
Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis., PMID:39877352
Fuzi decoction ameliorates intervertebral disc degeneration through ferroptosis modulation by suppressing NF-κB pathway., PMID:39874850
Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation., PMID:39861077
Endarachne binghamiae Extract Ameliorates Inflammatory Responses in Macrophages Through Regulation of MAPK, NF-kB and PI3K/AKT Pathways, and Prevents Acute Lung Injury in Mice., PMID:39860028
Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel., PMID:39856099
Anti-Inflammatory Effects of Cannabigerol In Vitro and In Vivo Are Mediated Through the JAK/STAT/NFκB Signaling Pathway., PMID:39851511
Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome., PMID:39824371
Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity., PMID:39814017
Deciphering the Anti-Diabetic Potential of Gymnema Sylvestre Using Integrated Computer-Aided Drug Design and Network Pharmacology., PMID:39810481
Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury., PMID:39806436
Wnt3a Enhances Mesenchymal Stem Cell Engraftment and Differentiation in a Chronic Obstructive Pulmonary Disease Rat Model., PMID:39802038
The Astragalus Membranaceus Herb Attenuates Leukemia by Inhibiting the FLI1 Oncogene and Enhancing Anti-Tumor Immunity., PMID:39769192
Preclinical Assessment of Safety and Efficacy of Deferoxamine (DFO)-pretreated Feline Adipose Mesenchymal Stem Cells., PMID:39740892
Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy., PMID:39740397
SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β., PMID:39726047
For research use only. Not for human or drug use.
