Catalog No.
EHK31001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Pro505
Predicted molecular weight
59.25 kDa
Nature
Recombinant
Concentration
0.7 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9C0B1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Liquid
Storage buffer
PBS pH 7.4, 0.02% NaN3, 50% glycerol
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alpha-ketoglutarate-dependent dioxygenase FTO, Fat mass and obesity-associated protein, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, 1.14.11.-, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO, 1.14.11.-, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, m6A(m)-demethylase FTO, 1.14.11.-, mRNA N(6)-methyladenosine demethylase FTO, 1.14.11.53, tRNA N1-methyl adenine demethylase FTO, 1.14.11.-, FTO, KIAA1752
FTO inhibition enhances the therapeutic index of radiation therapy in head and neck cancer., PMID:40485587
Increased susceptibility to prostate cancer biomarkers in the offspring of male mouse progenitors with lifelong or early life exposure to high-fat diet., PMID:40481981
Enterovirus 71 structural viral protein 1 promotes the expression of PMP22 through m6A modification in mouse Schwann cells., PMID:40480313
Unraveling the Obesity-Combating Potential of Parabacteroides goldsteinii and Bacteroides sartorii: A Dual-Probiotic Approach., PMID:40471533
Puerarin suppresses the oxidative stress and activates the cyclic AMP (cAMP)/cAMP response element binding protein/brain-derived neurotrophic factor signaling pathway in alcohol withdrawal-induced depressive disorder via regulating obesity-associated protein-mediated N6-methyladenosine demethylation., PMID:40470634
Spherical Nucleic Acids as Modulators of CRISPR/Cas12a by a Steric Barrier Effect for Designing Versatile Biosensors., PMID:40469012
Berbamine inhibits cell proliferation and invasion by increasing FTO expression in renal cell carcinoma cells., PMID:40457236
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer., PMID:40448344
Mechanistic role of FTO in cancer pathogenesis, immune evasion, chemotherapy resistance, and immunotherapy response., PMID:40446483
Mechanisms of Fat Mass and Obesity-Associated Protein in Regulating Cognitive Impairment Induced by Sevoflurane Anesthesia in Neonatal Rats., PMID:40445378
Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway., PMID:40437442
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia., PMID:40435251
White Adipocyte Stem Cell Expansion Through Infant Formula Feeding: New Insights into Epigenetic Programming Explaining the Early Protein Hypothesis of Obesity., PMID:40429638
Ultrasensitive detection of atrazine by Schottky junction photoelectrochemical aptamer sensor based on signal amplification by cascade catalysis of CRISPR/Cas12a and G-quadruplex/hemin DNAzyme., PMID:40425955
Impact of recognition of genetic information related to BMI on changes in physical activity, dietary intake, and blood cholesterol level: a randomized controlled trial., PMID:40423790
Exosomal miR-1246 of adipose stem cells attenuates obesity by polarizing M2 macrophages, reducing fat mass, and beiging of white adipose tissue., PMID:40419017
Protein and total sugars intake modulate the rs9939609 single nucleotide polymorphism effect at the fat mass and obesity-associated gene on body composition., PMID:40414497
Exploring the interplay of genetic variants and environmental factors in childhood obesity: A systematic review and meta-analysis., PMID:40412510
Mechanisms underlying obesity-malignancy connection: a systematic narrative review., PMID:40408050
Polymorphisms in the FTO Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta-Analysis., PMID:40391584
N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells., PMID:40389988
FTO Promotes Hepatocellular Carcinoma Progression by Mediating m6A Modification of BUB1 and Targeting TGF-βR1 to Activate the TGF-β Signaling Pathway., PMID:40385944
The m6A demethylase FTO controls Th1 differentiation and immunity against infections., PMID:40378511
Role and mechanisms of m6A demethylases in digestive system tumors., PMID:40371134
FTO promotes post-stroke neuroprotection by m6A demethylation of c-Jun., PMID:40370319
[Effect of Xingnao Kaiqiao acupuncture technique on m6A methylation modification in cortical area of rats with cerebral ischemia-reperfusion injury]., PMID:40369924
Analysis of Genotype and Expression of FTO and ALKBH5 in a MENA-Region Renal Cell Carcinoma Cohort., PMID:40361322
FTO alleviated the diabetic nephropathy progression by regulating the N6-methyladenosine levels of DACT1., PMID:40356725
[Xinyang Tablets ameliorate ventricular remodeling in heart failure via FTO/m6A signaling pathway]., PMID:40350823
Decreased FTO Expression Promotes Ovarian Granulosa Cells Aging., PMID:40342080
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet., PMID:40334773
FTO facilitates colorectal cancer chemoresistance via regulation of NUPR1-dependent iron homeostasis., PMID:40334546
The m6A methylation system limits hepatitis B virus replication., PMID:40326019
Silencing METTL3 and YTHDF2 increases HSP70 expression and promotes corneal epithelial healing., PMID:40324710
FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion., PMID:40316995
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2., PMID:40316061
TNF-α inhibites non-small cell lung cancer cells proliferation by targeting THRIL in an FTO-YTHDF2-dependent manner., PMID:40311994
Identifying pyroptosis-related prognostic genes in the co-occurrence of lung adenocarcinoma and COPD via bioinformatics analysis., PMID:40307363
The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation., PMID:40307231
Developments of the mDZ-RhoBAST Probe for Super-Resolution Imaging of FTO Demethylation in Live Cells., PMID:40295165
FTO-mediated m6A demethylation of KLF4 promotes the proliferation and collagen deposition of keloid fibroblasts., PMID:40291597
Gut microbes-spinal connection is required for itch sensation., PMID:40289281
Aberrant overexpression of m6A writer and reader genes in pediatric B-Cell Acute Lymphoblastic Leukemia (B-ALL)., PMID:40288000
Fusion of glioma-associated mesenchymal stem/stromal cells with glioma cells promotes macrophage recruitment and M2 polarization via m6A modification of CSF1., PMID:40287444
Effect of RNA Demethylase FTO Overexpression on Biomass and Bioactive Substances in Diatom Phaeodactylum tricornutum., PMID:40282280
Topical application of insulin encapsulated by chitosan-modified PLGA nanoparticles to alleviate alkali burn-induced corneal neovascularization., PMID:40278870
KYNA Ameliorates Hepatic Ischemia-Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO-Dependent m6A Demethylation of LATS1., PMID:40277037
Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration., PMID:40272981
MiR-27a-3p protects against NaAsO2-induced neuronal apoptosis in HT22 cells., PMID:40269215
Baicalein disrupts TGF-β-induced EMT in pancreatic cancer by FTO-dependent m6A demethylation of ZEB1., PMID:40262723
For research use only. Not for human or drug use.
